Evaluation of in-vitro Anthelmintic Activity of Ximenia americana, Hopea ponga and Vitex leucoxylon

Shettar, Arun Kashivishwanath; Vedamurthy, A. B.

doi:10.5530/pj.2017.3.62

Cited by 3 publications

(3 citation statements)

References 9 publications

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“…Further, leading to easy entry of other phytochemicals, linkage of intracellular enzymes, and as a result some cellular metabolic activities are either increased or reduced and others completely inhibited. On the other hand, phenols contained in the extract (niclosamide, oxyclozanide and bithionol) may act by uncoupling the mitochondrial reaction involved in electron transport for ATP generation [19,20]. This could make the worm weak, thus causing paralysis and eventually death.…”

Section: Time Of Paralysis and Deathmentioning

confidence: 99%

Determination of phytochemicals and anthelmintic activity of Rytigynia kigeziensis Verdc extracts using Eudrilus eugeniae model

Asiimwe¹,

Ondari²,

Odongo³

et al. 2023

World J. Adv. Res. Rev.

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Helminthic infections are among the global public health problems. Due to high cost of standard drugs and resistance, rural dwellers use herbal preparations. However, efficacy and mechanisms of action remains elusive. In Uganda, Rytigynia kigeziensis is one of the commonly used anthelmintic herbs. The current study sought to determine the effect of phytochemicals in R. kigeziensis from the stem bark against E. eugeniae model for application as anthelmintic. The anthelmintic activity was carried out by time of paralysis and time of death at various at concentrations (15, 25, 50 and 100 mg/ml). Further LDH activity was examined to shade light on the possible mechanism of inhibition. All the results obtained were expressed as mean values ± SEM (n=3). The significance of difference between the means of albendazole and extracts concentrations were determined using One-way ANOVA on PAST version 3.15 and regarded significant at P ≤ 0.05. The phytochemicals extracted were in the order ethanol> methanol> aqueous> ethyl acetate> chloroform whereby alkaloids, flavonoids, saponins, glycosides, steroids, anthraquionones and tannins were present in all the extracts. Phlobatannins were absent in all extracts while terpenoids were absent in ethyl acetate, reducing sugars and phenols were also not observed in chloroform extracts. The anthelminthic activity was dose dependent in all extracts in the order ethanol>methanol>ethyl-acetate>aqueous>chloroform extracts. The LDH activity was dose dependent and statistically significant. The results were statistically significant when compared against albendazole. The findings suggest synergistic effect R. kigeziensis stem bark extracts, and the plant may serve as a potential anthelminthic agent.

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Section: Time Of Paralysis and Deathmentioning

confidence: 99%

Determination of phytochemicals and anthelmintic activity of Rytigynia kigeziensis Verdc extracts using Eudrilus eugeniae model

Asiimwe¹,

Ondari²,

Odongo³

et al. 2023

World J. Adv. Res. Rev.

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“…Plants naturally contain phytochemical substances that produce definite physiological action in human body, especially nontoxic plants [1]. A good example is C. citratus (lemongrass), which belongs to the Gramineae family [2].…”

Section: Introductionmentioning

confidence: 99%

“…Which is a gram-positive coccus bacterium; its cells form grape-like clusters when viewed under an appropriate microscope. S. aureus is one of the main causes of nosocomial and community-acquired infections [1]. P. aeroginosa is an aerobic gram-negative bacillus considered to be an opportunistic pathogen [6].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activities of Cymbopogon citratus and Ximenia Americana Leaf Extracts Against Some Selected Bacterial and Yeast Clinical Isolates

Hassan

Madu

Ozojiofor

et al. 2021

AJBGMB

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Increasing emergence of resistance to antibiotics by pathogenic microorganisms worldwide necessitates the need for finding new antimicrobial agents with minimal resistance and side effects. This study was carried out to investigate the phytochemical content and antimicrobial activities of two ethno-medicinal plants namely: Cymbopogon citratus and Ximenia Americana. Methanol and aqueous were used as solvent for a soxhlet and aqueous percolation extraction techniques to obtain the crude extracts of the named plant parts. Tannins, steroids, reducing sugars, tritapenoids and Flavonoids were found present in these plant extracts. GC-MS analysis done in this study indicates the presence of some basic phenolic compounds, such as; Cyclohexane-1-3,5-trione & 2-phenyl-1,4-benzopyrone, in the C. citratus extract and methyl guanidine & 3-meyhylheptyl acetate in the X. americana extract, which have been attributed with numerous antimicrobial effects onmicrobial pathogens. Using an agar well diffusion bioassay technique the C. citratus extracts shows; both the extracts are active against E. coli and P. aeroginosa. While X. americana extracts shows a higher activity against C. albican. However the MIC/MBC/MFC of all the extracts shows that known of the extracts has an active viability below 12.5µg/ml.

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Mechanistic Insight Into Medicinal Properties of Indonesian Diverse Mangrove Species: A Review

MUHTADI,

PAMBUDI,

MARYATI

2024

Int J App Pharm

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Mangrove ecosystems in Indonesia harbor a rich diversity of plant species, some of which have been traditionally recognized for their medicinal properties. This study aims to provide mechanistic insights into the medicinal potential of various mangrove species found in Indonesian coastal regions. Through a comprehensive analysis of pharmacological activities and underlying mechanisms, our research seeks to elucidate the therapeutic properties of these diverse mangrove plants. The key terms "Mangrove", "Pharmacological", and "Indonesia" used for searching in three online databases: Science Direct, PubMed, and Google Scholar. The investigation into the pharmacological properties of mangrove species revealed versatile mechanisms of action. Notably, a convergence is observed in their antioxidant mechanisms, as exemplified by Aegiceras corniculatum, Avicennia marina, and Rhizophora mucronata, showcasing robust effects in DPPH, ABTS, and FRAP assays. Additionally, the study highlights significant findings in the realm of anti-inflammatory activities. Mangrove species like Aegialitis rotundifolia, Ceriops decandra, and Rhizophora apiculata demonstrate notable anti-inflammatory effects by inhibiting enzymes like LOX and responding positively to carrageenan induction. A commonality is unveiled in antibacterial effects, with species like Avicennia marina, Ceriops tagal, and Excoecaria agallocha exhibiting potent antibacterial properties in agar diffusion assays. These findings underscore the potential of mangrove species in combating microbial infections through distinct antibacterial mechanisms. Furthermore, understanding the mechanisms behind the medicinal properties of Indonesian mangrove species is crucial for both conservation efforts and the development of novel pharmaceuticals.

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Evaluation of in-vitro Anthelmintic Activity of Ximenia americana, Hopea ponga and Vitex leucoxylon

Cited by 3 publications

References 9 publications

Determination of phytochemicals and anthelmintic activity of Rytigynia kigeziensis Verdc extracts using Eudrilus eugeniae model

Determination of phytochemicals and anthelmintic activity of Rytigynia kigeziensis Verdc extracts using Eudrilus eugeniae model

Antimicrobial Activities of Cymbopogon citratus and Ximenia Americana Leaf Extracts Against Some Selected Bacterial and Yeast Clinical Isolates

Mechanistic Insight Into Medicinal Properties of Indonesian Diverse Mangrove Species: A Review

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