Evaluation of insulin sensitivity and glucose effectiveness during a standardized breakfast test: comparison with the minimal model analysis of an intravenous glucose tolerance test

Aloulou, I.; Brun, J.‐F.; Mercier, Jacques

doi:10.1016/j.metabol.2006.01.002

Cited by 39 publications

(34 citation statements)

References 54 publications

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“…Insulin resistance was estimated by calculating the following fasting indices: HOMA-IR [22], QUICKI [23] and insulin sensitivity index of blood NEFA [24]. Additionally, dynamic insulin sensitivity indices-glucose effectiveness Sg [25] and the Cederholm index [26]-integrating plasma glucose and insulin concentrations during the OGTT, were used.…”

Section: Dietary Supplementsmentioning

confidence: 99%

Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT)

et al. 2018

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Aims/hypothesis Insoluble cereal fibres have been shown in large prospective cohort studies to be highly effective in preventing type 2 diabetes, but there is a lack of interventional data. Our 2 year randomised double-blind prospective intervention study compared the effect of an insoluble oat fibre extract with that of placebo on glucose metabolism and incidence of diabetes. Methods A total of 180 participants with impaired glucose tolerance underwent a modified version of the 1 year lifestyle training programme PREvention of DIAbetes Self-management (PREDIAS) and were randomised to receive a fibre supplement (n = 89; 7.5 g of insoluble fibre per serving) or placebo (n = 91; 0.8 g of insoluble fibre per serving) twice daily for 2 years. Eligible participants were men and women, were at least 18 years old and did not report corticosteroid or other intensive anti-inflammatory treatment, fibre intolerance or any of the following disorders: overt diabetes, chronic or malignant disease, or severe cardiopulmonary, endocrine, psychiatric, gastrointestinal, autoimmune or eating disorder. Participants were recruited at two clinical wards in Berlin and Nuthetal. The allocation was blinded to participants and study caregivers (physicians, dietitians, study nurses). Randomisation was conducted by non-clinical staff, providing neutrally numbered supplement tins. Both supplements were similar in their visual, olfactory and gustatory appearance. Intention-to-treat analysis was applied to all individuals. Results After 1 year, 2 h OGTT levels decreased significantly in both groups but without a significant difference between the groups (fibre −0.78 ± 1.88 mmol/l [p ≤ 0.001] vs placebo −0.46 ± 1.80 mmol/l [p = 0.020]; total difference 0.32 ± 0.29 mmol/l; Caroline Honsek and Stefan Kabisch contributed equally to this publication.Electronic supplementary material The online version of this article (https://doi.org/10.1007/s00125-018-4582-6) contains peer-reviewed but unedited supplementary material, which is available to authorised users. not significant). The 2 year incidence of diabetes was 9/89 (fibre group) compared with 16/91 (placebo group; difference not significant). As secondary outcomes, the change in HbA 1c level was significantly different between the two groups (−0.2 ± 4.6 mmol/mol [−0.0 ± 0.0%; not significant] vs +1.2 ± 5.2 mmol/mol [+0.1 ± 0.0%; not significant]; total difference 1.4 ± 0.7 mmol/mol [0.1 + 0.0%]); p = 0.018); insulin sensitivity and hepatic insulin clearance increased in both groups. After 2 years, improved insulin sensitivity was still present in both groups, although the effect size had diminished. Separate analysis of the sexes revealed a significantly greater reduction in 2 h glucose levels for women in the fibre group (−0.88 ± 1.59 mmol/l [p ≤ 0.001] vs −0.22 ± 1.52 mmol/l [p = 0.311]; total difference 0.67 ± 0.31 mmol/l; p = 0.015). Levels of fasting glucose, adipokines and inflammatory markers remained unchanged in the two groups. Significantly increased fibre intake was restricted ...

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Section: Dietary Supplementsmentioning

confidence: 99%

Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT)

et al. 2018

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“…At t ¼ 20 min, an intravenous bolus of regular human insulin (0.03 U/kg, diluted to 10 mL with normal saline) was administered over approximately 1 min. In total, 21 blood samples were collected at the following pre-and post-glucose infusion timepoints: t ¼ À10, À5, 3,5,7,10,12,14,16,19,22,25,30,40, 50, 60, 75, 90, 120, 150, and 180 min.…”

Section: Ivgtt Proceduresmentioning

confidence: 99%

“…[10][11][12][13][14][15][16] However, use of a solid food mixed meal has some disadvantages, including difficulty in standardization across multiple research sites and potential variability introduced by differences in the degree to which subjects chew solid food items. A liquid MTT (LMTT) protocol has the advantage of being simple to prepare and administer in a standardized fashion in multicenter investigations and studies with repeated measurements over time.…”

Section: Introductionmentioning

confidence: 99%

Validation of Insulin Sensitivity and Secretion Indices Derived from the Liquid Meal Tolerance Test

Maki

Kelley

Lawless

et al. 2011

Diabetes Technology & Therapeutics

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“…Recently, due to the development of glucagon-like peptide-1 receptor agonists (GLP-1RAs) and dipeptidyl peptidase IV (DPP-4) inhibitors, the concept of insulin being stimulated by nutrients, other than plasma glucose only, entering the gastrointestinal tract has been more greatly appreciated [15][16][17][18]. Thus, a mixed meal tolerance test (MTT) that contains all nutrients might be a better challenge.…”

Section: Subjectsmentioning

confidence: 99%

Evaluation of second phase insulin secretion with simple surrogates derived from the mixed meal tolerance test in patients with type 2 diabetes

et al. 2013

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Abstract. The major contributors to the pathogenesis of type 2 diabetes are impaired insulin action and insulin secretion, including second phase insulin secretion (2 nd ISEC). This study aimed to compare surrogates derived from the mixed meal tolerance test (MTT) with 2 nd ISEC derived from modified low-dose graded glucose infusion (M-LDGGI) in patients with type 2 diabetes. We were subsequently able to decide which surrogate would be performed easily and accurately. Twenty type 2 diabetes patients were enrolled. They received both MTT and M-LDGGI. The standardized MTT meals were provided at 8:00 A.M. and 12:00 P.M. The M-LDGGI was a simplified version of the Polonsky method; only two 80-min stages of glucose infusion (2 and 6 mg/kg/min) were given. The slopes of the insulin to glucose curve during the test were regarded as the 2 nd ISEC. First, we used the area under the insulin curve (AUC IN ) during MTT to quantify the 2 nd ISEC. The best correlated AUC IN was from 60-240 min. Second, the slopes between any two time points of the plasma insulin to glucose level (SLOPE I/G ) were also assessed. The time period best correlated with 2 nd ISEC was from 0-120 min (SLOPE 0-120 ). Finally, the insulin-toglucose ratio (IG r ) of each time point was used to estimate the 2 nd ISEC, and the best correlation was observed at 180 min. In conclusion, estimating 2 nd ISEC surrogates derived from MTT proved to be possible. The most accurate surrogate is the SLOPE 0-120 , while IG r180 is another less precise but more convenient method.

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Evaluation of insulin sensitivity and glucose effectiveness during a standardized breakfast test: comparison with the minimal model analysis of an intravenous glucose tolerance test

Cited by 39 publications

References 54 publications

Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT)

Fibre supplementation for the prevention of type 2 diabetes and improvement of glucose metabolism: the randomised controlled Optimal Fibre Trial (OptiFiT)

Validation of Insulin Sensitivity and Secretion Indices Derived from the Liquid Meal Tolerance Test

Evaluation of second phase insulin secretion with simple surrogates derived from the mixed meal tolerance test in patients with type 2 diabetes

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