Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods

Zhang, Dong; Song, Xiaojing; Li, Shun-Yue; Wang, Shuyou; Chen, Bing-jun; Bai, Xiaodong; Tang, L.

doi:10.1038/srep30119

Cited by 16 publications

(9 citation statements)

References 32 publications

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“… 51 In an acute alcoholic liver-injury model, EA improved hepatic circulation and adjusted ALT and AST levels. 52 Finally, systemic inflammatory response and survival rate are significantly improved by EA in animals injected with a lethal dose of LPS. 53 Major studies on the regulation of inflammation by EA are summarized in Table 1 .…”

Section: Experimental Studies On Ea Using Pathologic Animal Modelsmentioning

confidence: 99%

Electroacupuncture therapy in inflammation regulation: current perspectives

Park

Namgung

2018

JIR

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Although acupuncture therapy is increasingly used to treat diverse symptoms and disorders in humans, its underlying mechanism is not known well. Only recently have experimental studies begun to provide insights into how acupuncture stimulation generates and relates to pathophysiological responsiveness. Acupuncture intervention is frequently used to control pathologic symptoms in several visceral organs, and a growing number of studies using experimental animal models suggest that acupuncture stimulation may be involved in inducing anti-inflammatory responses. The vagus nerve, a principal parasympathetic nerve connecting neurons in the central nervous system to cardiovascular systems and a majority of visceral organs, is known to modulate neuroimmune communication and anti-inflammatory responses in target organs. Here, we review a broad range of experimental studies demonstrating anti-inflammatory effects of electroacupuncture in pathologic animal models of cardiovascular and visceral organs and also ischemic brains. Then, we provide recent progress on the role of autonomic nerve activity in anti-inflammation mediated by electroacupuncture. We also discuss a perspective on the role of sensory signals generated by acupuncture stimulation, which may induce a neural code unique to acupuncture in the central nervous system.

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Section: Experimental Studies On Ea Using Pathologic Animal Modelsmentioning

confidence: 99%

Electroacupuncture therapy in inflammation regulation: current perspectives

Park

Namgung

2018

JIR

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“…Moreover, clinical studies have shown that adiponectin plays an active role in the pathophysiology of vascular disease in patients with NAFLD [37]. Speckle blood flow imaging technology is a new auxiliary technique for evaluating liver function [38]. In this study, the liver perfusion of the CDAA group was significantly lower than that of the normal group, and SL increased the liver perfusion.…”

mentioning

confidence: 57%

Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c

Tang

Deng

Zheng

et al. 2020

Oxidative Medicine and Cellular Longevity

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Background. Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disease worldwide, and its incidence is increasing annually, but there is currently no specific drug for treating NAFLD. Shenling Baizhu powder (SL) is a safe herbal compound commonly used in clinical practice. Our previous research has shown that SL has the effect of preventing NAFLD, but its specific mechanism has not been determined. In this study, the potential mechanism of SL on NAFLD was explored by in vivo experiments. Methods. Wistar rats fed a choline-deficient amino acid-defined diet (CDAA) were treated with SL for 8 weeks. Then, serum samples were collected to obtain biochemical indicators; adipose tissue and liver samples were collected for pathological detection; a moorFLPI-2 blood flow imager was used to measure liver microcirculation blood flow, and a rat cytokine array was used to screen potential target proteins. The expression of liver adiponectin/SREBP-1c pathway-related proteins was determined by Western blotting. Results. SL effectively reduced the liver wet weight, as well as the levels of total cholesterol (TC) and triglyceride (TG) in the liver, and ameliorated liver injury in CDAA-fed rats. Pathological examinations showed that SL markedly reduced liver lipid droplets and improved liver lipid accumulation. In addition, the detection of liver blood flow showed that SL increased liver microcirculation in CDAA-fed rats. Through the cytokine array, a differentially expressed cytokine, namely, adiponectin, was screened in the liver. Western blotting assays showed that SL increased the expression of adiponectin and phosphoacetyl-CoA Carboxylase (p-ACC) in the liver and decreased the expression of steroid regulatory element-binding protein-1c (SREBP-1c) and fatty acid synthase (FAS). Conclusion. These results suggest that SL can increase the levels of adiponectin in the liver and serum and can inhibit the expression of SREBP-1c, thereby regulating systemic lipid metabolism and reducing liver lipid accumulation.

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“…Inhibition of Candidalysin production can reduce the inflammatory response and thus benefit patients; (4) Acupuncture and moxibustion. Research has shown that electroacupuncture stimulation changed the levels of vasoactive substances to increase hepatic microcirculation perfusion and promote indocyanine green clearance, thereby improving hepatic microcirculation and reserve function, protecting liver function in animals with acute ALD[ 151 ]. Though the clinical application of acupuncture is widely studied, there are relatively few studies on acupuncture for ALD.…”

Section: Microbiota-gut-liver-brain Axis and Aldmentioning

confidence: 99%

Role of gut microbiota via the gut-liver-brain axis in digestive diseases

Ding¹,

Jin²,

Yang³

et al. 2020

WJG

110

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The gut-brain axis is a bidirectional information interaction system between the central nervous system (CNS) and the gastrointestinal tract, in which gut microbiota plays a key role. The gut microbiota forms a complex network with the enteric nervous system, the autonomic nervous system, and the neuroendocrine and neuroimmunity of the CNS, which is called the microbiota-gut-brain axis. Due to the close anatomical and functional interaction of the gut-liver axis, the microbiota-gut-liver-brain axis has attracted increased attention in recent years. The microbiota-gut-liver-brain axis mediates the occurrence and development of many diseases, and it offers a direction for the research of disease treatment. In this review, we mainly discuss the role of the gut microbiota in the irritable bowel syndrome, inflammatory bowel disease, functional dyspepsia, non-alcoholic fatty liver disease, alcoholic liver disease, cirrhosis and hepatic encephalopathy via the gut-liver-brain axis, and the focus is to clarify the potential mechanisms and treatment of digestive diseases based on the further understanding of the microbiota-gut- liver-brain axis.

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Evaluation of liver function and electroacupuncture efficacy of animals with alcoholic liver injury by the novel imaging methods

Cited by 16 publications

References 32 publications

Electroacupuncture therapy in inflammation regulation: current perspectives

Electroacupuncture therapy in inflammation regulation: current perspectives

Prevention of Nonalcoholic Hepatic Steatosis by Shenling Baizhu Powder: Involvement of Adiponectin-Induced Inhibition of Hepatic SREBP-1c

Role of gut microbiota via the gut-liver-brain axis in digestive diseases

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