Evaluation of macular and optic disc radial peripapillary vessel density with optical coherence tomography angiography in iron deficiency anemia

Koca, Semra; Bozkurt, Erhan; Eroğul, Özgür; Yavasoglu, Filiz; Doğan, Mustafa; Joshi, Mohan P

doi:10.1016/j.pdpdt.2022.102744

Cited by 4 publications

(4 citation statements)

References 23 publications

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“…Oxidative stress and inflammation occurring in DN might also accelerate the process of retinal vascular endothelial cell impairment (21). Furthermore, anaemia in DN secondary to erythropoietin reduction, uraemic toxin accumulation and dialysis might be responsible for capillary impairment, as stated in previous studies (22,23).…”

Section: Discussionmentioning

confidence: 77%

Is preclinical diabetic retinopathy in diabetic nephropathy individuals more severe?

Yao

2023

Front. Endocrinol.

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PurposeTo analyse the retinal vessel density and thickness characteristics of diabetic nephropathy (DN) individuals with preclinical diabetic retinopathy (DR) using optical coherence tomography angiography (OCTA).MethodsThis retrospective case−control study included 88 eyes of 88 type 2 DM patients with preclinical DR [44 non-DN (NDN) and 44 DN]. OCTA images and data were acquired using AngioVue 2.0 of the spectral domain OCT device. The foveal avascular zone (FAZ) area, superficial capillary plexus (SCP) and deep capillary plexus vessel densities, ganglion cell complex (GCC) and full retinal thicknesses, peripapillary capillary density and nerve fibre layer (RNFL) thickness were compared between the NDN and DN groups. The relationship between each renal function parameter and each OCTA parameter was analysed.ResultsSCP vessel density, GCC thickness and full retinal thickness were significantly reduced in DN individuals compared to NDN individuals [(NDN versus DN) SCP vessel density: 46.65 ± 3.84% versus 44.35 ± 5.25%, p=0.030; GCC thickness: 100.79 ± 5.92 μm versus 93.28 ± 8.66 μm, p<0.001; full retinal thickness: whole area: 287.04 ± 13.62 μm versus 277.71 ± 15.10 μm, p=0.005). Within the peripapillary area, capillary density was also significantly reduced in the whole area (50.19 ± 3.10% versus 47.46 ± 5.93%, p=0.016) and some sectors in the DN group, though RNFL thickness was only decreased in some sectors. For all individuals, estimated glomerular filtration rate (eGFR) correlated significantly with most OCTA parameters and then showed a significantly negative correlation with FAZ area (β=−16.43, p=0.039) in multivariate linear regression analysis. In the NDN group, eGFR showed a significantly negative correlation with FAZ area (β=−18.746, p=0.048) and a significantly positive correlation with SCP vessel density (β=0.580, p=0.036).ConclusionPreclinical DR may be more severe in DN individuals than in NDN individuals with regard to microvascular and microstructural impairment. Moreover, eGFR may be a good indicator for retinal microvascular impairment.

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Section: Discussionmentioning

confidence: 77%

Is preclinical diabetic retinopathy in diabetic nephropathy individuals more severe?

Yao

2023

Front. Endocrinol.

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“…We identified a reduced FAZ area and higher PD in PA than HC, which contradicts previous studies that suggest an enlarged FAZ area and decreased vessel density due to an ischaemic environment in the anaemic subjects with sickle cell disease [23][24][25][26] and IDA. 12 The reason for the discrepancy may be the duration of anaemia. Compared with anaemia that has plagued some participants for years, anaemia during pregnancy is a relatively short-term state caused by a temporary increase in blood volume, hormone fluctuations, a lack of iron, etc.…”

Section: Discussionmentioning

confidence: 99%

“…Finally, whole retina vessel perfusion decreases in chronic anaemia, and the FAZ enlarges due to devascularisation resulting from the long-term lack of oxygen and nutrition. 12–14 23 25 31 …”

Section: Discussionmentioning

confidence: 99%

“…11 The literature has investigated that retinal and choriocapillaris (CC) blood perfusion decrease on OCTA in patients with IDA and sickle cell anaemia. [12][13][14] However, most previous studies focused only on patients with chronic anaemia. Studying anaemia during pregnancy allows us to advance our understanding of ocular alterations earlier in the disease course.…”

Section: Clinical Sciencementioning

confidence: 99%

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Optical coherence tomography angiography for the characterisation of retinal microvasculature alterations in pregnant patients with anaemia: a nested case‒control study

Wang

et al. 2022

Br J Ophthalmol

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AimsTo characterise retinal microvascular alterations in the eyes of pregnant patients with anaemia (PA) and to compare the alterations with those in healthy controls (HC) using optical coherence tomography angiography (OCTA).MethodsThis nested case‒control study included singleton PA and HC from the Eye Health in Pregnancy Study. Fovea avascular zone (FAZ) metrics, perfusion density (PD) in the superficial capillary plexus, deep capillary plexus and flow deficit (FD) density in the choriocapillaris (CC) were quantified using FIJI software. Linear regressions were conducted to evaluate the differences in OCTA metrics between PA and HC. Subgroup analyses were performed based on comparisons between PA diagnosed in the early or late trimester and HC.ResultsIn total, 99 eyes of 99 PA and 184 eyes of 184 HC were analysed. PA had a significantly reduced FAZ perimeter (βcoefficient=−0.310, p<0.001), area (βcoefficient=−0.121, p=0.001) and increased circularity (βcoefficient=0.037, p<0.001) compared with HC. Furthermore, higher PD in the central (βcoefficient=0.327, p=0.001) and outer (βcoefficient=0.349, p=0.007) regions were observed in PA. PA diagnosed in the first trimester had more extensive central FD (βcoefficient=4.199, p=0.003) in the CC, indicating impaired perfusion in the CC.ConclusionIt was found that anaemia during pregnancy was associated with macular microvascular abnormalities, which differed in PA as pregnancy progressed. The results suggest that quantitative OCTA metrics may be useful for risk evaluation before clinical diagnosis.Trial registration numbers2021KYPJ098 and ChiCTR2100049850.

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Quantitative detection of macular microvascular abnormalities identified by optical coherence tomography angiography in different hematological diseases

Jian,

Xu,

et al. 2024

Sci Rep

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Evaluation of macular and optic disc radial peripapillary vessel density with optical coherence tomography angiography in iron deficiency anemia

Cited by 4 publications

References 23 publications

Is preclinical diabetic retinopathy in diabetic nephropathy individuals more severe?

Is preclinical diabetic retinopathy in diabetic nephropathy individuals more severe?

Optical coherence tomography angiography for the characterisation of retinal microvasculature alterations in pregnant patients with anaemia: a nested case‒control study

Quantitative detection of macular microvascular abnormalities identified by optical coherence tomography angiography in different hematological diseases

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