Evaluation of Macular Ischemia in Eyes With Central Retinal Vein Occlusion

Ghashut, Rima; Muraoka, Yuki; Ooto, Sotaro; Iida, Yuto; Miwa, Yuko; Suzuma, Kiyoshi; Murakami, Tomoaki; Kadomoto, Shin; Tsujikawa, Akitaka; Yoshimura, Nagahisa

doi:10.1097/iae.0000000000001749

Cited by 48 publications

(30 citation statements)

References 35 publications

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“…Several reports [8, 9] have been published recently that evaluate the relationship between macular ischemia and visual function using OCT, OCTA, and microperimetry in eyes with RVO. However, the relationship between retinal ischemia and ME or MA was not examined, and the thickness of the entire retina was measured, not of each retinal layer.…”

Section: Introductionmentioning

confidence: 99%

Structural and Functional Analyses of Retinal Ischemia in Eyes with Retinal Vein Occlusion: Relationship with Macular Edema or Microaneurysm Formation

et al. 2018

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Purpose: To study the structural and functional changes of retinal ischemia and investigate their association with macular edema (ME) or microaneurysm (MA) formation in eyes with retinal vein occlusion (RVO). Methods: Sixty eyes of 30 patients (27 eyes with branch [b]RVO, 3 with central RVO, and 30 fellow eyes) were retrospectively reviewed. Optical coherence tomography (OCT), OCT angiography (OCTA), and microperimetry were performed simultaneously to measure retinal thickness and sensitivity. The presence of ME or MA was also assessed using OCT and fluorescein angiography. Results: The mean retinal sensitivity in the nonperfused areas (NPAs) deteriorated, and this was significantly (r = –0.379, p = 0.0391*) and inversely correlated with duration from disease onset. ME and MA were unlikely to be observed around the area where the retinal sensitivity decreased. In the NPAs, the mean retinal thickness of the superficial capillary plexus (SCP) (p < 0.0001), deep capillary plexus (DCP) (p = 0.0323), and outer retina (p = 0.0008) were significantly thinner than those in the fellow eyes, respectively. Multivariate regression analysis revealed that the thicknesses of the DCP (β: 0.3107, p = 0.0007) and outer retina (β: 0.3482, p = 0.0001) were the independent correlative factors of the retinal sensitivity, but that SCP thickness was not. Conclusion: Deep retinal thinning in NPAs was correlated significantly with a decreased retinal sensitivity, which might be a negative predictor of ME and MA in eyes with RVO.

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Section: Introductionmentioning

confidence: 99%

Structural and Functional Analyses of Retinal Ischemia in Eyes with Retinal Vein Occlusion: Relationship with Macular Edema or Microaneurysm Formation

et al. 2018

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“…Kadomoto et al analyzed RVO patients and showed that visual acuity was associated with the defect length of the foveal EZ band. Macular sensitivity assessed by microperimetry was found to be correlated with the length of EZ disruption [24]. Correlation between visual acuity and EZ disruption was also found in diabetic eyes [4].…”

Section: Plos Onementioning

confidence: 74%

Identification of microvascular and morphological alterations in eyes with central retinal non-perfusion

Hajdu¹,

Told²,

Angeli³

et al. 2020

PLoS ONE

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Purpose To evaluate the characteristics and morphological alterations in central retinal ischemia caused by diabetic retinopathy (DR) or retinal vein occlusion (RVO) as seen in optical coherence tomography angiography (OCTA) and their relationship to visual acuity. Methods Swept-source optical coherence tomography (SSOCT) and OCTA (Topcon, Triton) data of patients with central involving retinal ischemia were analyzed in this cross-sectional study. The following parameters were evaluated: vessel parameters, foveal avascular zone (FAZ), intraretinal cysts (IRC), microaneurysms (MA), vascular collaterals in the superficial (SCP) and deep plexuses (DCP), hyperreflective foci (HRF), epiretinal membrane (ERM), external limiting membrane (ELM) and ellipsoid zone (EZ) disruption, as well as the disorganization of retinal inner layers (DRIL). Best-corrected visual acuity (BCVA), age, gender, disease duration and ocular history were also recorded. Results 44 eyes of 44 patients (22 with RVO, 22 with DR) were analyzed. The mean age was 60.55 ± 11.38 years and mean BCVA 0.86 ± 0.36 (Snellen, 6m). No significant difference was found between DR subgroups (non proliferative vs. proliferative). Between RVO subgroups (CRVO vs. BRVO) a significant difference was found in term of collateral vessel of the DCP (p = 0.014). A pooled DR and RVO group were created and compared. Significantly more MAs (p = 0.007) and ERM (p = 0.007) were found in the DR group. Statistically significant negative correlation was demonstrated between FAZ and BCVA (p = 0.45) when analyzing all patients with retinal ischemia. Conclusion This study has shown that the best predictor of visual outcome in center involved ischemic diseases is the size of FAZ. Besides the presence of MAs and ERM, all other OCT and OCTA parameters were present in a similar extent in DR and RVO group despite the completely different disease origins. Our results suggest that as soon as retinal ischemia in the macular region is present, it has a similar appearance and visual outcome independently of the underlying disease.

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“…7,9,10 Compared to the older imaging modalities, optical coherence tomography (OCT) and OCT angiography (OCTA) enable detailed evaluation of the retinal vasculature parallel or perpendicular to the retinal plane. [11][12][13][14][15][16][17][18][19][20][21] Our recent investigations using OCT 22 or OCTA 14 have indicated that BRVO caused by venous overcrossing might be more prevalent than previously reported and that these cases involve more highly narrowed veins at the causative crossings and a larger retinal non-perfusion area than cases caused by arterial overcrossing. However, the viewing angle of OCT and OCTA used in these investigations might not have been sufficiently large to allow evaluation of retinal vasculature other than at causative crossings.…”

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confidence: 84%

Angiographic Risk Features of Branch Retinal Vein Occlusion Onset as Determined by Optical Coherence Tomography Angiography

Kogo

Muraoka

Iida

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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Citation: Kogo T, Muraoka Y, Iida Y, et al. Angiographic risk features of branch retinal vein occlusion onset as determined by optical coherence tomography angiography. Invest Ophthalmol Vis Sci. 2020;61(2):8. https://doi.org/10.1167/iovs.61.2.8 PURPOSE.Examine associations between the vasculature at arteriovenous (AV) crossings and the onset of branch retinal vein occlusion (BRVO). METHODS.We included 78 patients with major BRVO, 35 patients with macular BRVO, and 110 controls without BRVO and determined the vessel positions at AV crossings, where the first-or second-order branches of the retinal veins associate, using a viewing angle of 12 × 12 mm 2 in optical coherence tomography angiography (OCTA). RESULTS.We reviewed 1349 and 1276 AV crossings in BRVO patients and control subjects, respectively. The proportions of venous overcrossing were 26.5%, 28.6%, and 26.8% at non-causative crossings in BRVO eyes, non-BRVO fellow eyes, and unaffected control eyes, respectively; however, the rate of venous overcrossings at the causative crossings was 45.1%. In OCTA analyses, we divided the branches into macular-or non-macular veins. The rate of venous overcrossing was 52.5% at causative crossings in major BRVO but was 28.6% in macular BRVO. Odds ratios for whether venous overcrossing was a risk factor for BRVO were 3.09 (95% confidence interval [CI], 1.96-4.88) and 0.94 (95% CI, 0.44-2.00) for non-macular veins and macular veins, respectively. The patients with major BRVO caused by venous overcrossing were younger than patients for whom the cause was arterial overcrossing (P < 0.001). The onset of macular BRVO did not differ between crossing patterns at causative crossings (P = 0.60). CONCLUSIONS.In eyes with BRVO, venous overcrossing was a common angiographic feature at causative crossings and might be a risk factor for major BRVO onset.

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Evaluation of Macular Ischemia in Eyes With Central Retinal Vein Occlusion

Cited by 48 publications

References 35 publications

Structural and Functional Analyses of Retinal Ischemia in Eyes with Retinal Vein Occlusion: Relationship with Macular Edema or Microaneurysm Formation

Structural and Functional Analyses of Retinal Ischemia in Eyes with Retinal Vein Occlusion: Relationship with Macular Edema or Microaneurysm Formation

Identification of microvascular and morphological alterations in eyes with central retinal non-perfusion

Angiographic Risk Features of Branch Retinal Vein Occlusion Onset as Determined by Optical Coherence Tomography Angiography

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