Evaluation of Materials for the Separation of Germanium from Gallium, Zinc and Cobalt

Fitzsimmons, Jonathan; Mausner, L.F.

doi:10.17265/1934-7375/2015.07.006

Cited by 4 publications

(2 citation statements)

References 9 publications

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“…The studies indicated very high germanium concentrations could be obtained, but cobalt retention on Sephadex © G25 was identical to germanium (Fitzsimmons and Mausner, 2015a). This approach would require 4-5 columns to purify 68 Ge that meet specifications.…”

Section: Introductionmentioning

confidence: 99%

Production scale purification of Ge-68 and Zn-65 from irradiated gallium metal

Fitzsimmons

Mausner

2015

Applied Radiation and Isotopes

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Germanium-68 (Ge-68) is produced by proton irradiation of a gallium metal target, purified by organic extraction and used in a medical isotope generator to produce Gallium-68 PET imaging agents. The purpose of this work was to implement a production scale separation of Ge-68 and Zn-65 that does not use organic solvents and uses a limited number of columns. The current separation approach was modified to use AG1 resin and/or Sephadex(©) G25 with zinc spikes to purify Ge-68 with near quantitative recovery. The purified Ge-68 meets DOE specifications. Methods utilizing zinc spikes resulted in the purist Ge-68 produced at Brookhaven National Lab with no other impurities by ICP-OES. During process optimization approximately 2.5 Ci of Ge-68 was purified utilizing the different processing methods, and the material was sold to the Nuclear Medicine community between 2012-2013.

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Section: Introductionmentioning

confidence: 99%

Production scale purification of Ge-68 and Zn-65 from irradiated gallium metal

Fitzsimmons

Mausner

2015

Applied Radiation and Isotopes

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“…We examined separations chemistry starting after the leaching step. In the initial studies we evaluated the purification of Ge from Co, Ga, and Zn with a three column approach using an alkaline solution [12]. The separations used Sephadex © G25 resin and produced germanium in very high concentrations.…”

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confidence: 99%

Development of a production scale purification of Ge-68 from irradiated gallium metal

Fitzsimmons

Mausner

2014

Radiochimica Acta

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is produced by proton irradiation of a gallium metal target and purified by organic extraction. The Ge-68 can be used in a medical isotope generator to produce Gallium-68 (Ga-68) which can be used to radiolabel PET imaging agents. The emerging use of Ge-68 in the Ga-68 medical isotope generator has caused us to develop a new purification method for Ge-68 that does not use toxic solvents. The purpose of this work was to develop a production scale separation of Ge-68 that utilizes a leaching step to remove a bulk of the gallium metal, followed by purification with Sephadex © G25. Production scale (300 mCi) purification was performed with the new method. The purified Ge-68 contained the highest radioactivity concentration of Ge-68 produced at BNL; the sample meet Department of Energy specifications and the method had an excellent recovery of Ge-68.

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Efficient extraction of ⁶⁸Ge from irradiated Ga–Ni alloy via a novel organic-solvent-free separation procedure

Xia,

Wu,

Gao

et al. 2023

Radiochimica Acta

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In this work, a gallium–nickel alloy target with a weight percentage ratio of 7:3 was successfully prepared on Cu substrate in a chloride system at room temperature. A novel organic-solvent-free separation procedure based on two columns for extracting 68Ge from irradiated Ga–Ni alloy target with high radionuclidic purity (99.99 %) was developed. By this separation procedure, the recovery of 68Ge is 95 ± 5 % and the yield of 68Ge via the nuclear reaction natGa(p,xn)68Ge was measured to be 0.27 ± 0.02 MBq/μA h.

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Evaluation of Materials for the Separation of Germanium from Gallium, Zinc and Cobalt

Cited by 4 publications

References 9 publications

Production scale purification of Ge-68 and Zn-65 from irradiated gallium metal

Production scale purification of Ge-68 and Zn-65 from irradiated gallium metal

Development of a production scale purification of Ge-68 from irradiated gallium metal

Efficient extraction of ⁶⁸Ge from irradiated Ga–Ni alloy via a novel organic-solvent-free separation procedure

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Evaluation of Materials for the Separation of Germanium from Gallium, Zinc and Cobalt

Cited by 4 publications

References 9 publications

Production scale purification of Ge-68 and Zn-65 from irradiated gallium metal

Production scale purification of Ge-68 and Zn-65 from irradiated gallium metal

Development of a production scale purification of Ge-68 from irradiated gallium metal

Efficient extraction of 68Ge from irradiated Ga–Ni alloy via a novel organic-solvent-free separation procedure

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Efficient extraction of ⁶⁸Ge from irradiated Ga–Ni alloy via a novel organic-solvent-free separation procedure