Evaluation of medicinal plants from Central Kalimantan for antimelanogenesis

Abstract

In the course of searching for new materials to use as whitening agents, we screened 19 methanol extracts prepared from 14 medicinal plants from Central Kalimantan province, Indonesia. The screening methods used were the 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging assay, a tyrosinase inhibition assay, and a melanin formation inhibition assay using B16 melanoma cells. The extracts of Willughbeia coriacea (bark part of aerial root), Phyllanthus urinaria (root), Eleutherine palmifolia (bulb), Eusideroxylon zwageri (seed), Dendrophthoe petandra (aerial root), Passiflora foetida (stem), and Vitex pinnata (root) showed DPPH radical-scavenging activity of more than 70% at 100 microg/ml. The extracts of W. coriacea (bark part of aerial root), P. urinaria (root), and D. petandra (aerial root) showed tyrosinase inhibitory activity of more than 40% using L-tyrosine as a substrate at 500 microg/ml. The extracts of W. coriacea (bark part of aerial root) and D. petandra (aerial root) showed tyrosinase inhibitory activity of more than 40% using L-DOPA as a substrate at 500 microg/ml. The extracts of W. coriacea (bark part of aerial root, 200 microg/ml), Glochidion philippcum (aerial root, 200 and 300 microg/ml), E. palmifolia (bulb, 50 microg/ml), E. zwageri (seed, 100 microg/ml), D. petandra (aerial root, 200 microg/ml), Lansium domesticum (bark, 25 microg/ml), P. foetida (stem, fruit, 300 microg/ml), and Solanum torvum (root, 300 microg/ml) strongly inhibited the melanin production of B16 melanoma cells without significant cytotoxicity. These findings indicate that some medicinal plants from Central Kalimantan are potential ingredients for skin-whitening cosmetics if their safety can be confirmed.

Phytochemical Screening and Antioxidant Activity of Selekop (Lepisanthes amoena) Fruit

“…The amount of antioxidant activity was characterized by the IC 50 (inhibitory concentration), that is a concentration of the sample solution indicated a potential antioxidant that was needed to reduce DPPH by 50 % (Arung, Kusuma, Christy, Shimizu, & Kondo, 2009).…”

Antiproliferative, Antioxidative and Compounds Identification from Methanolic Extract of Passiflora Foetida and Its Fractions

“…Extracts of P. foetida had been verified to have anticancer activities on in vivo and in vitro [10,11]. The present study is a report of cytotoxic investigation of P. foetida extract and fractions against cervical cancer cell line (HeLa), and the compounds which are possibly responsible for the antiproliferative activity which led to identification of tetradecanal and cis-11-hexadecenal.…”

Atividades biológicas dos óleos essenciais de Endlicheria citriodora, uma lauraceae rica em geranato de metila

“…Ao compararmos nossos resultados com os relatos da literatura para outros produtos naturais, entre óleos essenciais e extratos, verificamos que as CI 50 variam entre 79 -1600 µg/mL, sendo em sua maioria superiores a 100 µg/mL, confirmando assim o potencial cosmético do óleo de E. citriodora. [42][43][44][45][46] O uso de compostos sintéticos normalmente causa irritação na pele. Baseando-se nisso, os pesquisadores têm buscado utilizar compostos naturais no desenvolvimento de novos produtos, e várias substâncias já foram identificadas como potentes inibidores da tirosinase e da melanogênese.…”