Evaluation of Mitomycin C Effect on Corneal Endothelial Cell Density After Photorefractive Keratectomy

Abstract

Background: Photorefractive keratectomy (PRK) is a commonly performed surgical procedure for the correction of refractive errors, such as myopia. Mitomycin C (MMC) has been used as an adjunctive agent to modulate the healing response and reduce haze and fibrosis after PRK. However, the effect of MMC on corneal endothelial cell density, a crucial factor in maintaining corneal transparency and function, remains a subject of debate. This study aimed to evaluate the effect of intraoperative application of MMC 0.02% during PRK on corneal endothelial cell density.