Evaluation of multidetector computed tomography urography and ultrasonography for diagnosing bladder cancer

Knox, Matthew K.; Cowan, Nigel C.; Rivers-Bowerman, Michael D.; Turney, Ben

doi:10.1016/j.crad.2008.07.003

Cited by 56 publications

(22 citation statements)

References 31 publications

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“…The diagnostic value of DWMRI with sensitivity, specificity, positive predictive, negative predictive and accuracy values in our study was obtained with a mean lesion diameter of 37 8 2.7 mm. DWMRI has similar accuracy values to ultrasound for the diagnosis of tumoral lesions of this size and ultrasound is an easily available, cost-effective and safely performed technique for all individuals with no restrictions if adequate bladder distension is maintained [16] . Another limitation was the exclusion of lesions under 1 cm during the analysis.…”

Section: Discussionmentioning

confidence: 92%

Role of Diffusion MRI and Apparent Diffusion Coefficient Measurement in the Diagnosis, Staging and Pathological Classification of Bladder Tumors

Dağgülli¹,

Onur

Firdolas³

et al. 2011

Urol Int

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Objectives: Our aim was to investigate the role of simultaneous apparent diffusion coefficient (ADC) measurement and diffusion-weighted MRI (DWMRI) in the diagnosis and differentiation of bladder masses. Methods: Weexamined 45 patients presenting with hematuria by dynamic and diffusion MRI (at b100, b600, b1000 gradients) and cystoscopy. Thirty healthy volunteers without hematuria were also included in the study. Results from imaging techniques were compared to cystoscopic and histopathologic findings. The ADC values of benign and malignant bladder masses, and bladder tissue in healthy subjects were measured and compared with each other. Results: The mean ADC values of benign (n = 10) and malignant lesions (n = 35) were significantly lower than the mean ADC values of adjacent bladder walls and bladder walls of healthy subjects at all 3 gradients (p < 0.05). However, no significant difference was detected between benign and malignant lesions (p > 0.05). Mean ADC values of invasive tumors were significantly lower than superficial malignancies at b600 and b1000 gradients. The mean ADC values of transitional cell tumors were significantly higher than squamous cell tumors at b100 and b600 gradients. Conclusion: Simultaneous measurement ofADC and DWMRI provided useful information in the diagnosis, staging and histopathological classification of bladder tumors.

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Section: Discussionmentioning

confidence: 92%

Role of Diffusion MRI and Apparent Diffusion Coefficient Measurement in the Diagnosis, Staging and Pathological Classification of Bladder Tumors

Dağgülli¹,

Onur

Firdolas³

et al. 2011

Urol Int

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“…The homogeneous opacification of urine has been claimed to improve bladder cancer detection, particularly on the nondependent surface of the bladder. Specialized techniques have been suggested, such as having patients void prior to CT and then administering intravenous diuretics to increase bladder filling (13,29,30).…”

Section: Imaging Considerations Computed Tomographymentioning

confidence: 99%

Urinary Bladder Cancer: Role of MR Imaging

et al. 2012

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Urinary bladder cancer is a heterogeneous disease with a variety of pathologic features, cytogenetic characteristics, and natural histories. It is the fourth most common cancer in males and the tenth most common cancer in females. Urinary bladder cancer has a high recurrence rate, necessitating long-term surveillance after initial therapy. Early detection is important, since up to 47% of bladder cancer-related deaths may have been avoided. Conventional computed tomography (CT) and magnetic resonance (MR) imaging are only moderately accurate in the diagnosis and local staging of bladder cancer, with cystoscopy and pathologic staging remaining the standards of reference. However, the role of newer MR imaging sequences (eg, diffusion-weighted imaging) in the diagnosis and local staging of bladder cancer is still evolving. Substantial advances in MR imaging technology have made multiparametric MR imaging a feasible and reasonably accurate technique for the local staging of bladder cancer to optimize treatment. In addition, whole-body CT is the primary imaging technique for the detection of metastases in bladder cancer patients, especially those with disease that invades muscle.

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“…Knox et al [19], in a study comparing CT urography and ultrasonography for diagnosing BCa, found specificities of CT urography and ultrasonography for the diagnosis of BCa to be similar, CT urography ¼ 96.5%, ultrasonography ¼ 94.7%, but CT urography was more sensitive (Se ¼ 89.7%) than ultrasonography (Se ¼ 69%). In patients testing positive on CT urography or ultrasonography, it is suggested that initial assessment by flexible cystoscopy is replaced by direct referral to rigid cystoscopy for more thorough evaluation and possible biopsy and transurethral resection (TUR).…”

Section: Diagnosis: Ultrasonographymentioning

confidence: 89%

Imaging bladder cancer

Cowan

Crew

2010

Current Opinion in Urology

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Imaging for BCa should only be performed when it makes a difference to patient management. CT is the preferred imaging modality for diagnosing and staging urothelial cancer. Magnetic resonance (MR) imaging is superior for evaluation of the depth of tumour invasion into the bladder wall, but this knowledge may not ultimately affect treatment as feasibility for radical cystectomy depends on staging by a combination of clinical, histopathological and imaging findings. Radical cystectomy may include resection of adjacent organs and regional lymph nodes. The current purpose of CT or MR imaging is to detect T3b disease or higher and, especially, locoregional lymph node metastases. In the future, MR imaging with ultrasmall superparamagnetic iron oxide contrast agents may detect lymph nodes containing metastatic tumour, which may change treatment from surgery to chemotherapy with or without radiotherapy.

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Evaluation of multidetector computed tomography urography and ultrasonography for diagnosing bladder cancer

Cited by 56 publications

References 31 publications

Role of Diffusion MRI and Apparent Diffusion Coefficient Measurement in the Diagnosis, Staging and Pathological Classification of Bladder Tumors

Role of Diffusion MRI and Apparent Diffusion Coefficient Measurement in the Diagnosis, Staging and Pathological Classification of Bladder Tumors

Urinary Bladder Cancer: Role of MR Imaging

Imaging bladder cancer

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