Evaluation of nasal mucociliary clearance time in children with celiac disease

Comba, Atakan; Atan, Doğan

doi:10.1016/j.ijporl.2020.109936

Cited by 9 publications

(6 citation statements)

References 26 publications

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“…It is noteworthy that only 10% of patients required hospitalization in the CD cohort. This is striking, given the well-documented evidence for worse outcomes with respiratory infections in CD patients [ 3 , 4 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Outcomes of SARS-CoV-2 infection in patients with celiac disease: a multicenter research network study

Hadi¹

2022

aog

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Background Celiac disease (CD) is associated with an increased risk for respiratory infections and severe outcomes. No data have been reported in the scientific literature regarding the outcomes of COVID-19 in this population. The aim of this study was to report matched clinical outcomes in a large cohort of 930 patients with COVID-19 in the setting of known CD. Methods Analysis of a multicenter research network TriNETX was performed, including COVID-19 patients aged more than 16 years. Outcomes of COVID-19-positive patients with concurrent CD were compared with a propensity-matched cohort of patients without CD. Results A total of 341,499 patients with SARS-CoV-2 infection were identified on the research network: 930 (0.27%) with CD and 340,569 (99.73%) without CD. In the 30- and 60-day periods post SARS-CoV-2 infection, 12 (1.29%) and 13 (1.40%) deaths, respectively, were reported in the CD group. Fewer patients in the CD group reached the composite outcome of either mechanical ventilation or mortality at 60 days (risk ratio 0.58, 95% confidence interval 0.36-0.95). After propensity matching, no difference in clinical outcomes was observed. Conclusion Our data suggest that patients with CD are not at increased risk of COVID-19-related morbidity or mortality.

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Section: Discussionmentioning

confidence: 99%

Outcomes of SARS-CoV-2 infection in patients with celiac disease: a multicenter research network study

Hadi¹

2022

aog

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“…9,10 chronic obstructive airways disease, and lymphocytic broncoalveolit and some repetetive (recurrent) alveolary-intersistel lung diseases related to rhinosinusitis have been reported, their associated pathogenesis could not be explained for a long time. [9][10][11] But studies evaluating nasal functions in CD are infrequent in the literature.…”

Section: Discussionmentioning

confidence: 99%

“…Comba and Atan reported that nasal MCC was increased in celiac patients. 11 MCC has ability to keep the mucosal surface moist and clean and via respirotary mucosa which has regular activity to eject pathogens. 12 It is a vital defense mechanism of the respiratory system and protects the body from the harmful effects of inhaled particles.…”

Section: Discussionmentioning

confidence: 99%

Does Celiac Disease Affect Smell Sensation, Mucociliary Clearance and Nasal Smear?

BERKİTEN,

TUTAR,

GÖKDEN

et al. 2024

KBB ve BBC Dergisi

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We aimed to evaluate olfactory function and nasal smear cytology in patients with celiac disease (CD) and healthy volunteers. Material and Methods: In this study, a total 74 subjects including 38 CD patients and 36 healthy controls were involved. CD has been verified by serological tests and small intestine biopsy. Sniffin Stick test was used to evaluate olfactory function. Nasal mucociliary clearance (MCC) time was measured with saccharin test. Neutrophils, eosinophils, basophilic and goblet cells were evauluted in nasal cytology. Sniffin test findings, MCC, nasal cytology and response to treatment with diet findings of CD patients and control group have been compared. Results: In CD group, normosmia was detected in 20 patients, and hiposmia in 17 patients. Total smell score (TDI) was 35±4 in control group, while it was 31±8 in CD group. The difference between two groups was statistically significant (p=0.009). While there was no statistically significant difference between the groups in terms of discrimination (DIS) and identification (ID) scores (p=0.277; p=0.960), the mean theroshold (THR) was found to be statistically significantly lower in the CD group (p=0.018). No evident difference has been determined between the two groups in terms of nasal MCC duration (p=0.948). While there was no statistically signicant difference in the average goblet cell grade, eosinophil, neutrophil, and lymphocyte grade average differences were significant (p=0.001). There was no statistically remarkable difference between diet compliant and non-diet compliant group in terms of THR, DIS, ID, and TDI scores (p>0.05). Conclusion: In our study, deterioration of nasal functions and nasal cytological findings-in particularly lymphocyte infiltration-makes it possible to think that CD group is a systemic disease that affects all organs, especially mucous membranes.

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“…The mucociliary clearance serves as the first barrier of the nasal cavity and paranasal sinuses against various biological and physical damages [1]. Differences in mucociliary transport parameters between different nasal areas depend on the ciliary beat frequency, ciliary population density, ciliary length, and mucus quality [10].…”

Section: Discussionmentioning

confidence: 99%

The Condition of Mucociliary Clearance in Patients With Nasal Septum Deviation and Postnasal Drip Syndrome

Babchenko

2023

Clin. and prev. med.

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Introduction. Mucociliary clearance is a vital defense mechanism in the human upper respiratory tract that safeguards the body against inhaled harmful substances. Ciliary activity was first discovered by Sharpey in 1835, and it took nearly a century for this function to be recognized as a central component in the physiology of the sinuses. The aim of this study is to investigate the status of mucociliary clearance in patients with a nasal septum deviation and concomitant postnasal drip syndrome. Materials and Methods: A total of 54 patients, aged between 23 and 55 years, were enrolled in the study. All participants underwent a saccharin test and an assessment of the motor activity of the ciliated epithelium. Exclusion criteria included the presence of infectious and inflammatory diseases of the upper respiratory tract within the last month. Results: In the control group of patients, no significant difference was observed in the speed of saccharin test passage, both in the right and left parts of the nasal cavity, with test times ranging from 8.35 to 14.52 minutes. However, in the second clinical group comprising patients with nasal septum deviation, the average time for the saccharin test on the mucous membrane of the concave side of the nasal septum was significantly longer than on the convex side, measuring 21.52 ± 3.04 minutes and 12.36 ± 2.73 minutes, respectively (P = 0.02). When assessing the data from patients in the third clinical group based on the curvature side, a significant difference (P < 0.05) was observed in the reduction of saccharin test speed compared to the control group. Conclusions: The data obtained indicate a significant influence of nasal septum deviation on subsequent changes in nasal cavity physiology, resulting in a slowdown of mucociliary clearance. This can lead to excessive mucus stagnation in the nasal cavity and, consequently, the development of postnasal drip syndrome.

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Evaluation of nasal mucociliary clearance time in children with celiac disease

Cited by 9 publications

References 26 publications

Outcomes of SARS-CoV-2 infection in patients with celiac disease: a multicenter research network study

Outcomes of SARS-CoV-2 infection in patients with celiac disease: a multicenter research network study

Does Celiac Disease Affect Smell Sensation, Mucociliary Clearance and Nasal Smear?

The Condition of Mucociliary Clearance in Patients With Nasal Septum Deviation and Postnasal Drip Syndrome

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