Evaluation of Nerve Conduction Studies in Obese Children With Insulin Resistance or Impaired Glucose Tolerance

İnce, Hülya; Taşdemir, Haydar Ali; Aydın, Murat; Özyürek, Hamìt; Tilki, Hacer Erdem

doi:10.1177/0883073814550188

Cited by 13 publications

(9 citation statements)

References 41 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…An attenuate cerebrovascular reserve (CVR) has been observed in patients with diabetes or non-diabetic IR (39,40). Previous studies discovered that IR is involved in CVR through Bayliss effect, and chemical, neuronal, and metabolic mechanisms (41)(42)(43)(44). Last, IR enlarges the role of modifiable risk factors in IS, such as hypertension, diabetes, dyslipidemia, and cigarette smoking (45)(46)(47).…”

Section: Discussionmentioning

confidence: 99%

Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke

Zhou

Pan

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

Background: The triglyceride glucose index (TyG index) has been proposed as a simple and credible surrogate marker of insulin resistance. However, it is unclear whether TyG index correlates with adverse clinical outcomes in patients with ischemic stroke. Accordingly, this study aimed to explore the relationship between baseline TyG index and clinical outcomes of ischemic stroke individuals. Methods: We included eligible subjects with ischemic stroke from the China National Stroke Registry II for the current analysis. TyG index was calculated and divided into quartiles to explore the relationship with the outcomes of ischemic stroke. Outcomes included stroke recurrence, all-cause mortality, poor functional outcome at 12 months, and neurologic worsening at discharge. Multivariable Cox regression and logistic regression models were performed to explore the correlation of baseline TyG index with the outcomes. Results: Among the 16,310 patients enrolled in the study, the average age was 64.83 ± 11.9 years, and 63.48% were men. The median TyG index was 8.73 (interquartile range, 8.33-9.21). After adjustment for multiple potential covariates, the fourth quartile of TyG index was associated with an increased risk of stroke recurrence (adjusted HR, 1.32; 95% CI, 1.11-1.57; P = 0.002), all-cause mortality (adjusted HR, 1.25; 95%CI, 1.06-1.47; P = 0.01) at 12-month follow-up, and neurological worsening (adjusted OR, 1.26; 95% CI, 1.02-1.55; P = 0.03) at discharge, but not poor functional outcome compared with the first quartile. Conclusion: TyG index representing insulin resistance was associated with an increased risk of stroke recurrence, all-cause mortality, and neurologic worsening in patients with ischemic stroke.

show abstract

Section: Discussionmentioning

confidence: 99%

Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke

Zhou

Pan

et al. 2020

Front. Neurol.

View full text Add to dashboard Cite

show abstract

“…Autonomic neuropathy is common in diabetes populations with potential dysfunctions of cardiovascular, gastrointestinal, genitourinary systems and sudomotor or ocular functions [4,5]. In addition, recent studies have shown that individuals with oral glucose intolerance can also develop autonomic neuropathy [6][7][8]. Sudomotor function disturbance is considered one of the initial components of autonomic neuropathy, and its assessment may contribute to the detection of autonomic dysfunction in diabetics; in fact, the American Diabetes Association suggests that sudomotor function assessing small fiber status should be included in the diagnostic tests for the detection of neuropathies in diabetes [5].…”

Section: Introductionmentioning

confidence: 99%

EZSCAN as a Screening Tool for Prediabetes and Diabetes in a Large Mexican Population

OE¹

2015

J Diabetes Metab

View full text Add to dashboard Cite

Objective: Autonomic neuropathy especially small C-Fibers innervating sweat glands is common in diabetes and occurs in pre-diabetes. EZSCAN, a new and non-invasive device that precisely assesses sudomotor function was evaluated as a screening tool for pre-diabetes and diabetes in a large Mexican population. Methods: The study was performed in Hospital Regional "Lic. Adolfo Lopez Mateos" ISSSTE center. Subjects were classified as pre-diabetic or diabetic according to ADA criteria for fasting plasma glucose (FPG) and HbA 1C. EZSCAN test was performed and subjects were classified as no risk, moderate risk or high risk and its performance as a screening tool was assessed through ROC curve analysis. Results: Among the 1414 subjects involved in the study 357 had pre-diabetes and 64 had diabetes according to FPG confirmed by HbA 1C for 52 of them. Area under the Curve for EZSCAN to detect pre-diabetes or diabetes using FPG as reference were 0.65 and 0.73 respectively. Using 27 and 34 as threshold values for EZSCAN risk score for detection of pre-diabetes and diabetes sensitivity was 69% and 73%, specificity 56% and 70% and negative predictive value 82% and 98% respectively. The Odds Ratio (OR) for a patient classified as moderate risk with EZSCAN test was 2.06 (1.59-2.67) to have pre-diabetes and 15.8 (3.8-65.5) to have diabetes as compared to a subject with no risk. The OR was 4.32 (2.49-7.50) for pre-diabetes and 18.3 (3.3-102.5) for diabetes for a subject with high risk as compared to a subject with no risk. No adverse events during and after measurement with EZSCAN were reported. Conclusion: EZSCAN allowing quick and quantitative assessment of sudomotor function could be used as an early screening tool for pre-diabetes and diabetes in a large population before performance of more sophisticated and specific, but time-consuming and expensive tests.

show abstract

“…Nöronal gelişim, migrasyon, farklılaşma, miyelin üretimi gibi sinir sistemi ile ilişkili birçok önemli fonksiyonda görev alır (4)(5)(6). Hiperglisemi ve obeziteye ait diğer komplikasyonlar da sinir hasarına neden olabilmektedir (7,8). Bu sebeplerle artan çocukluk çağı obezitesi prevalansı sinir sistemine ait komplikasyonların erken yaşlarda başlamasına neden olabilmektedir.…”

Section: Introductionunclassified

Evaluation of somatosensory evoked potentials (seps) in obese children

Akın¹,

Ünay²,

Arslan³

et al. 2018

Gulhane Med J

View full text Add to dashboard Cite

Aims:This study aimed to investigate the somatosensory evoked potentials (SEPs) in obese children. Methods:A total of 62 children with obesity and 33 healthy children, as the control group, were enrolled in the study. Insulin resistance (IR) and other metabolic disturbances were investigated in all participants and obese children were divided into subgroups according IR presence. SEPs and other parameters were compared between subgroups.Results: Blood glucose, plasma insulin levels, and HOMA-IR were significantly higher in the IR+ Group. There was no significant difference between IR+ and IR-groups regarding other metabolic and anthropometric variables. There was no difference between IR+, IR-, and control groups in terms of SEPs. A significant correlation was found between N22 latency and HOMA-IR, and plasma insulin levels. Conclusions:Although there is a partial relationship between SEPs and IR, SEPs measurement my not be an appropriate screening test for determining neuropathies in patients who don't have severe metabolic disturbance.

show abstract

Evaluation of Nerve Conduction Studies in Obese Children With Insulin Resistance or Impaired Glucose Tolerance

Cited by 13 publications

References 41 publications

Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke

Triglyceride Glucose Index and Prognosis of Patients With Ischemic Stroke

EZSCAN as a Screening Tool for Prediabetes and Diabetes in a Large Mexican Population

Evaluation of somatosensory evoked potentials (seps) in obese children

Contact Info

Product

Resources

About