Evaluation of optical coherence tomography as a non‐invasive diagnostic tool in cutaneous wound healing

Kuck, M; Strese, Helene; Alawi, Seyed Arash; Meinke, Martina C.; Fluhr, Joachim W.; Burbach, Guido J.; Krah, Martin; Sterry, Wolfram; Lademann, Jürgen

doi:10.1111/srt.12077

Cited by 41 publications

(32 citation statements)

References 39 publications

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“…Additionally, the swirled dermal patterns observed here have been linked previously to collagen type III being converted to type I (61,69). This is corroborated by the bright dermis imaged immediately below the now healed wound indicating enhanced collagenous activity (65). One parameter often used in assessing wound healing is wound contraction.…”

Section: Discussionsupporting

confidence: 56%

“…The onset of the proliferation phase was seen here on the 5th day with the migration of horizontal angiogenic sprouts into the wound, thought to be symptomatic of the recruitment of fibroblasts from adjacent tissues, as well as the differentiation of fibrocytes to fibroblasts (63,64). The early onset of revascularization, i.e., superficial angiogenic sprouts, typically coincides with the onset of re-epithelialization, which can be observed with the tightening of the wound from its edge (65). Here, this tightening also coincided with the appearance of bright structural features.…”

Section: Discussionmentioning

confidence: 96%

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Optical coherence tomography angiography monitors human cutaneous wound healing over time

Deegan¹,

Men²,

Li³

et al. 2018

Quant. Imaging Med. Surg.

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Background: In vivo imaging of the complex cascade of events known to be pivotal elements in the healing of cutaneous wounds is a difficult but essential task. Current techniques are highly invasive, or lack the level of vascular and structural detail required for accurate evaluation, monitoring and treatment. We aimed to use an advanced optical coherence tomography (OCT)-based angiography (OCTA) technique for the noninvasive, high resolution imaging of cutaneous wound healing.Methods: We used a clinical prototype OCTA to image, identify and track key vascular and structural adaptations known to occur throughout the healing process. Specific vascular parameters, such as diameter and density, were measured to aid our interpretations under a spatiotemporal framework.Results: We identified multiple distinct, yet overlapping stages, hemostasis, inflammation, proliferation, and remodeling, and demonstrated the detailed vascularization and anatomical attributes underlying the multifactorial processes of dermatologic wound healing.Conclusions: OCTA provides an opportunity to both qualitatively and quantitatively assess the vascular response to acute cutaneous damage and in the future, may help to ascertain wound severity and possible healing outcomes; thus, enabling more effective treatment options.

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Section: Discussionsupporting

confidence: 56%

Section: Discussionmentioning

confidence: 96%

Optical coherence tomography angiography monitors human cutaneous wound healing over time

Deegan¹,

Men²,

Li³

et al. 2018

Quant. Imaging Med. Surg.

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“…Using computer-assisted threedimensional quantification for evaluation of wound volume [60], flexible pressure monitoring system for monitoring of local pressure [61], high-resolution ultrasound, and optical coherence tomography (OCT) [62] are reported as non-invasive diagnostic tools in monitoring of cutaneous wound healing.…”

Section: Discussionmentioning

confidence: 99%

Grafting with Cryopreserved Amniotic Membrane versus Conservative Wound Care in Treatment of Pressure Ulcers: A Randomized Clinical Trial

Dehghani

Azarpira

Karimi

et al. 2017

BEAT

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Objective:To compare the healing process of pressure ulcers treated with cryopreserved human amniotic membrane allograft and routine pressure ulcer care in our hospital. Methods: From January 2012 to December 2013, in a prospective randomized clinical trial (IRCT201612041335N2), 24 patients with second and third stage of pressure ulcers were enrolled in this study. All patients needed split thickness skin grafts for pressure ulcer-wound coverage. Selected patients had symmetric ulcers on both upper and lower extremities. The patients were randomly divided into two groups: amnion and control. In the amnion group, the ulcer was covered with cryopreserved amniotic membrane and in the control group it was treated with local Dilantin powder application. The duration and success rate of complete healing was compared between the two groups. Results: The study group was composed of 24 pressure ulcers in 24 patients (19 males and 5 females) with a mean age of 44±12.70 years. The demographic characteristics, ulcer area, and underlying diseases were similar in both groups. The early sign of response, such as decrease in wound discharge, was detected 12-14 days after biological dressing. Complete pressure ulcer healing occurred only in the amnion group (p<0.001). Partial healing was significantly higher in the amnion group (p<0.03). Healing time in this group was faster than that the control group (20 days versus 54 days). No major complication was recorded with amniotic membrane dressing. Conclusion: Cryopreserved amniotic membrane is an effective biologic dressing that promotes reepithelialization in pressure ulcers.

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“…In view of these limitations, optical imaging techniques have gained growing importance in the replacement of invasive histological analysis methods for wound status documentation [13,14,15]. Among the existing optical imaging techniques for wound characterization and wound healing assessment are confocal laser scanning microscopy, multiphoton laser microscopy, optical coherence tomography, hyperspectral imaging, infrared microscopy and confocal Raman microscopy [13,14,15,16,17,18]. In this work, we introduced optical profilometry as a novel technical approach to increase the accuracy of wound analysis.…”

Section: Resultsmentioning

confidence: 99%

“…For reliable and reproducible analytical evaluation of wound samples, there is a strong need for an alternative technology. Here, optical imaging methods have been gaining relevance as suitable tools for noninvasive wound analysis [13,14,15,16,17,18]. In this context, optical profilometry represents a novel technical possibility for nondestructive and label-free monitoring of wound topography.…”

Section: Introductionmentioning

confidence: 99%

Novel in vitro Approaches for the Simulation and Analysis of Human Skin Wounds

Planz

Franzen

Windbergs

2014

Skin Pharmacol Physiol

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Considering the increasing incidence of chronic wounds and severe wound infections, effective drug delivery to wounded skin is of high importance. The rational development of novel therapeutic systems requires appropriate in vitro testing methodologies. In this context, suitable and reliable in vitro models simulating human wounds and advanced analytical techniques for precise wound characterization are urgently needed. In this study, we introduce a novel in vitro model based on excised human skin. In contrast to the established wound models, our novel approach has a coffin-shaped, linear, rectangular geometry with defined wound edges exhibiting consistent appearance along the entire wound bed. In addition, we introduce optical profilometry as a novel technique for nondestructive wound analysis. We successfully demonstrate the applicability of this optical imaging method based on white light reflection for three-dimensional visualization of different wound models. Furthermore, we create virtual noninvasive cross sections of these wounds to assess wound geometry in direct comparison to conventional histological analysis. Imaging analysis of our novel coffin-shaped model resulted in reproducible virtual sections along the entire wound bed. Our findings indicate the potential of our novel in vitro model for improved simulation of human wounds. Further, we successfully overcome the limitations of conventional histological analysis by the employment of optical profilometry for nondestructive three-dimensional wound characterization. © 2014 S. Karger AG, Basel

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Evaluation of optical coherence tomography as a non‐invasive diagnostic tool in cutaneous wound healing

Abstract: Consequently, OCT could be a potential non-invasive diagnostic tool for the characterization and monitoring of cutaneous wound-healing processes over time.

Cited by 41 publications

References 39 publications

Optical coherence tomography angiography monitors human cutaneous wound healing over time

Optical coherence tomography angiography monitors human cutaneous wound healing over time

Grafting with Cryopreserved Amniotic Membrane versus Conservative Wound Care in Treatment of Pressure Ulcers: A Randomized Clinical Trial

Novel in vitro Approaches for the Simulation and Analysis of Human Skin Wounds

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