Evaluation of peripheral inflammatory markers, serum B12, folate, ferritin levels and clinical correlations in children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD)

Topal, Zehra; Tufan, Ali Evren; Karadağ, Mehmet; Gökçen, Cem; Akkaya, Canan; Sarp, Ayşe Sevde; Bahşi, İlhan; Kılınç, Metin

doi:10.1080/08039488.2021.1946712

Cited by 23 publications

(44 citation statements)

References 57 publications

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“…The incidence of low serum ferritin in ASD was 15.05%, but low serum ferritin was not a risk factor for ADHD or TD. The results are consistent with previous studies[ 25 - 27 ]. At the same time, we reported ferritin levels of children of different ages and sexes, which can provide an important reference for follow-up studies of iron deficiency in children with ADHD and TD.…”

Section: Discussionsupporting

confidence: 94%

“…This study uses the World Health Organization guidelines and expert consensus on the diagnosis and treatment of iron deficiency in China. The reference value limit is 15 μg/L[ 29 ], and the reference value range used in domestic studies on ADHD serum ferritin is 24 μg/L or 30 μg/L[ 25 , 27 ]. In related foreign studies, the limit of ADHD serum ferritin is set higher[ 12 ].…”

Section: Discussionmentioning

confidence: 99%

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Serum ferritin levels in children with attention deficit hyperactivity disorder and tic disorder

Tang¹,

Wen²

2022

WJCC

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BACKGROUND Iron plays an important role in neurodevelopmental functions in the brain. Serum ferritin levels are different in children with attention deficit hyperactivity disorder and tic disorder than in healthy children. AIM To explore the current status of iron deficiency in children with neurodevelopmental disorders and its sex and age effects. METHODS A total of 1565 children with attention deficit hyperactivity disorder (ADHD), 1694 children with tic disorder (TD), 93 children with ASD and 1997 healthy control children were included between January 1, 2020, and December 31, 2021 at Beijing Children's Hospital. We describe the differences in age levels and ferritin levels between different disease groups and their sex differences. The differences between the sexes in each disease were analyzed using the t test. The incidence rate of low serum ferritin was used to describe the differences between different diseases and different age groups. A chi-square test was used to analyze the difference in the incidence of low serum ferritin between the disease group and the control group. Analysis of variance was used for comparisons between subgroups, and regression analysis was used for confounding factor control. RESULTS A total of 1565 ADHD patients aged 5-12 years were included in this study, and the average serum ferritin levels of male and female children were 36.82 ± 20.64 μg/L and 35.64 ± 18.56 μg/L, respectively. A total of 1694 TD patients aged 5-12 years were included in this study, and the average serum ferritin levels of male and female children were 35.72 ± 20.15 μg/L and 34.54 ± 22.12 μg/L, respectively. As age increased, the incidence of low serum ferritin in ADHD and TD first decreased and then increased, and 10 years old was the turning point of rising levels. The incidence of ADHD with low serum ferritin was 8.37%, the incidence of TD with low serum ferritin was 11.04%, and the incidence of the healthy control group with low serum ferritin was 8.61%, among which male children with TD accounted for 9.25% and female children with TD accounted for 11.62%. There was a significant difference among the three groups ( P < 0.05). In addition, there were 93 children with ASD with an average serum ferritin level of 30.99 ± 18.11 μg/L and a serum ferritin incidence of 15.05%. CONCLUSION In conclusion, low serum ferritin is not a risk factor for ADHD or TD. The incidence of low serum ferritin levels in children with ADHD and TD between 5 and 12 years old decreases first and then increases with age.

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Section: Discussionsupporting

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Serum ferritin levels in children with attention deficit hyperactivity disorder and tic disorder

Tang¹,

Wen²

2022

WJCC

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“…Increased homocysteine may contribute to the pathogenesis of ADHD. Normal vitamin B12 and folate levels were found to be compatible with some previous studies (30).…”

Section: Discussionsupporting

confidence: 89%

Investigation of the relationship between vitamin D and peripheral inflammatory parameters in children with attention deficit and hyperactivity disorder

Esnafoğlu

2023

Konuralp Tıp Dergisi

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Aim: We aimed to investigate the effects of vitamin D and some nutritional factors such as vitamin B12, folate, homocysteine, and ferritin, which play a role in the pathogenesis of attention deficit and hyperactivity disorder (ADHD), on inflammation, which is also claimed to play a role in the pathogenesis of ADHD. Materials and methods: 39 ADHD and 39 healthy controls were compared with similar age, gender and BMI. The severity of the disease was evaluated with the Turgay ADHD scale. Inflammatory and nutritional parameters were measured routinely. Results: In the patient group, Vitamin D was found to be significantly lower (p

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“…Several authors pointed out that lower ferritin levels (<20 ng(mL) are found in patients with severe ASD, while other studies found no correlation between serum ferritin levels and autistic symptom scores [ 10 ]. Conflicting results are also seen regarding the relationship between ferritin and behavioral manifestations of other neurodevelopmental disorders such as ADHD (which were part of our OND group) [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Peripheral Iron Levels in Autism Spectrum Disorders vs. Other Neurodevelopmental Disorders: Preliminary Data

Giacomo

Medicamento

Pedaci

et al. 2022

IJERPH

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Autism Spectrum Disorder (ASD) is characterized by deficits in social skills and specific behaviors and interests. Among other environmental factors, iron may play a role in the development of ASD. The aim of this study is to compare the iron status of children with ASD with that of children affected by neurodevelopmental disorders other than ASD (OND). A total of 167 patients were enrolled, including 93 children with ASD and 74 children with OND. In the two groups, we determined ferritin, iron, transferrin, hemoglobin, HCT, and MCV in the serum. We found a significant difference in serum ferritin and MCV levels between the two groups (p < 0.05), with lower ferritin and higher MCV values in the ASD group. There was no significant association with the other variables. Our results may support the hypothesis of altered iron status in ASD, justifying more frequent examinations of blood iron parameters in these children.

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Evaluation of peripheral inflammatory markers, serum B12, folate, ferritin levels and clinical correlations in children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD)

Cited by 23 publications

References 57 publications

Serum ferritin levels in children with attention deficit hyperactivity disorder and tic disorder

Serum ferritin levels in children with attention deficit hyperactivity disorder and tic disorder

Investigation of the relationship between vitamin D and peripheral inflammatory parameters in children with attention deficit and hyperactivity disorder

Peripheral Iron Levels in Autism Spectrum Disorders vs. Other Neurodevelopmental Disorders: Preliminary Data

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