Evaluation of Polyvinyl Acetate Dispersion as a Sustained Release Polymer for Tablets

Abstract

Kollicoat SR 30D is a unique 30% aqueous dispersion of polyvinvyl acetate stabilized by polyvinyl-pyrrolidone intended for preparation of sustained release products. Detailed evaluation of this polymer dispersion as a sustained release coating for active pharmaceutical ingredients of two diverse classes of drugs was studied. A water insoluble drug (ibuprofen) and a water soluble drug (ascorbic acid) were selected as model active drugs. Ibuprofen was granulated using a GPCG-1 fluid bed processor prior to tableting, to improve the particle size and particle flow properties. In this process a 2(3) factorial design was implemented to evaluate the optimum process parameters such as spray rate, inlet air temperature and the inlet air velocity. The statistical model selected was Y(ijkl) = mu + tau(i) + beta(j) + theta(k) + (taubeta)ij + (betatheta)jk + (tautheta)ik + (taubetatheta)ijk + epsilon(ijkl). The factorial design showed that the spray rate, inlet air temperature, and inlet air velocity had a significant effect (p value <0.05) on the particle size. Significant improvement was observed in the flow properties of the granules. The granules were coated with Kollicoat SR30D dispersion using top spray method in the fluid bed processor. The dissolution studies showed that the release of ibuprofen decreased with an increase in the coating levels of Kollicoat SR 30 D. In the case of ascorbic acid, preparation of sustained release coated commercial granules was not possible due to the difficulty in coating a highly soluble drug particle. However, the coated granules when compressed into tablets showed some sustainability. Ibuprofen tablets manufactured with coated granules with a 15 g polymer for 300 g batch showed dissolution parameters of t50 and t90 at 4.2 hr and 7.5 hr, respectively. An approximate zero-type of release was observed when the polymer content was increased to 45 g for 300 g batch. Ascorbic acid tablets made with coated commercial granules having a total polymer content of 45 g per a 500 g batch showed an average dissolution t50 and t90 at 1.0 hr and 4.55 hr, respectively. When the total polymer content was increased to 60 g, per 500 g, the average dissolution t50 and t90 delayed to 1.40 hr and 7.20 hr, respectively.

Polyvinyl Acetate

“…1 The Expert Panel reviewed newly available studies since that assessment along with updated frequency and concentration of use information. 2 –11 The Expert Panel confirmed that polyvinyl acetate is safe in the present practices of use and concentration given in Table 1 and did not reopen this safety assessment.…”

Sustained release of diltiazem HCl tableted after co-spray drying and physical mixing with PVAc and PVP

“…Its major application is in membrane-controlled drug delivery systems [1][2][3][4][5][6][7] , but however, it has been successfully employed in matrix tablet preparation via fluidized-bed granulation 8 and spray drying 9 .…”

A Novel Approach to Prepare Poly(Vinyl Acetate)/Ag Nanocomposite for Effective Antimicrobial Coating Applications

“…Because of its high flexibility and low toxicity, polyvinyl acetate is widely used in the food industry as a base for chewing gum and for coating fruits and vegetables. From an environmental as well as economical point of view, aqueous-based systems are very much preferred over organic solvent-based systems [10,11]. Industrial applications of PVAc normally use it in the form of a liquefied emulsion.…”