Evaluation of Potentially Influential Factors for Positron Emission Tomography Image Quality in Liver Signal-to-noise Ratio Utilizing a Delivery 18F-fluoro-2-deoxy-D-glucose Study on Bi4Ge3O12-Positron Emission Tomography/Computed Tomography

Abstract

The findings of this study are potentially of use for designing imaging protocols for the BGO-PET/CT system when using commercially available FDG. It is easy to obtain good image quality for patients of low to average body size with the standard injection dose. However, large patients should be injected, wherever possible, with an FDG dose of up to 5 MBq/kg. The acquisition time in overweight and obese patients should be as longer as possible than in standard weight patients.

Impact of Region-of-Interest Delineation on Stability and Reproducibility of Liver SNR Measurements in 68Ga-PSMA PET/CT

“…[10][11][12] The signal-to-noise ratio (SNR) in the liver is commonly used as a standard metric for the qualitative and quantitative evaluation of the clinical PET images reconstructed with iterative reconstruction algorithms such as ordered subset expectation maximization (OSEM) and Bayesian penalized-likelihood reconstruction algorithm. 9,13,14 However, SNR in the liver has been shown to have a weak correlation with the visual assessment of PET clinical images. 15,16 On the other hand, liver 68 Ga uptake is not high and uniform and the placement of regions of interest (ROIs) or volumes of interest (VOIs) on the liver affects the reproducibility and stability of SNR.…”

“… 10 11 12 The signal-to-noise ratio (SNR) in the liver is commonly used as a standard metric for the qualitative and quantitative evaluation of the clinical PET images reconstructed with iterative reconstruction algorithms such as ordered subset expectation maximization (OSEM) and Bayesian penalized-likelihood reconstruction algorithm. 9 13 14 …”