Evaluation of PRDM1 gene polymorphism with hepatitis C virus-related hepatocellular carcinoma in a cohort of Egyptian patients

Abstract

The third most common cancer-related cause of death worldwide is hepatocellular carcinoma (HCC). and it is the sixth most common primary malignancy overall. Egypt had the hepatitis C virus's highest prevalence (HCV). A critical topic of study is the association between HCV and HCC. PR domain zinc finger protein 1 (PRDM1) functions as a tumor suppressor in B and T cells and is critical for plasma cell development and the exhaustion of T lymphocytes caused by cancer and chronic viral infections. Aim: This study aimed to compare Egyptian patients with HCC to a control group to determine the allele frequencies and genotype of the rs1010273 PRDM1 gene polymorphism. Methods: Included 200 Egyptian patients (100 HCC and 100 control). All participants underwent laboratory evaluations, comprising hepatitis markers (HBsAg, anti-HCV-Ab), liver function tests, serum alpha-fetoprotein, and complete blood count. Using the TaqMan allelic discrimination assay method, the PRDM1 rs1010273 was genotyped. Results: Unlike the healthy controls, the HCC patients had a greater frequency of the GA genotype (43% vs. 20%) and the A allele (26.5% vs. 10%). A significant difference was found between the GA and A allele of PRDM1genotype of HCC patients and controls (P<.001). Conclusions: A statistically significant and greater frequency of the A allele and GA genotype was found in HCC patients compared to controls, indicating a relationship between the PRDM1 AA+GA gene polymorphism and the HCC Egyptian population. The A allele was assumed to be a risk factor for HCC (OR=11.212). SNP (rs1010273G/A) may be an optional valuable marker.

Reviewing Advances in Understanding and Targeting the Mapk Signaling Pathway in Hepatocellular Carcinoma Progression and Therapeutics

“…The abnormal initiation of the MAPK pathway is linked to cellular transformation and carcinogenesis since it is a critical regulator of important cellular activities including cell survival and proliferation (Guo et al 2020;Hussain et al 2023). The TF phosphorylated by ERK modifies telomere repeats and prevents senescence by stimulating the telomerase catalytic gene (hTERT) (Jäger and Walter 2016).…”

Hepatocellular Carcinoma Incidence and Risk Factors: Insights into the Significance of Genetic Heterogeneity

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