Evaluation of pre- and postoperative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction.

Ajani, Jaffer A.; Roth, Jack A.; Ryan, Bernadette M.; McMurtrey, Marion J.; Rich, Tyvin A.; Jackson, Diane E.; Abbruzzese, James L.; Levin, Bernard; DeCaro, Louis F.; Mountain, Clifton F.

doi:10.1200/jco.1990.8.7.1231

Cited by 96 publications

(25 citation statements)

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“…1,3,4 Several authors have investigated the beneficial role of neoadjuvant chemoradiation therapy (CRT) in patients with potentially resectable esophageal adenocarcinoma to improve long-term survival. 5,6 Local preoperative staging of esophageal carcinoma with EUS is important in selecting better candidates for surgery and in determining which patients have potentially resectable disease. Studies have continued to support the utility of EUS in the initial staging of esophageal carcinoma.…”

mentioning

confidence: 99%

The accuracy of endoscopic ultrasound for restaging esophageal carcinoma after chemoradiation therapy

Kalha

Kaw

Fukami

et al. 2004

Cancer

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The study of fault detection and diagnosis of electrical machines, in particular induction motors, as well as the teaching of their behavior requires practical experience in this field. To provide this experience to the students this paper presents an experimental system that can be used with a standard industrial electrical induction machine. This system is based on only one healthy induction machine that is operated under faulty operating modes. Several fault types such as stator winding faults, bearing faults, or broken bars can be tested. The developed system also allows testing the behavior of the electrical machine for different load types. Several typical loads in which the torque depends of time or speed were implemented. The system is based on computer equipment with a DSPIC, a testing system and an induction machine. © 2010 Wiley Periodicals, Inc. Comput Appl Eng Educ 20: 611–618, 2012

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confidence: 99%

The accuracy of endoscopic ultrasound for restaging esophageal carcinoma after chemoradiation therapy

Kalha

Kaw

Fukami

et al. 2004

Cancer

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“…1 Carcinoma of the oesophagus and oesophagogastric junction has traditionally been associated with poor outcomes, both in terms of operative mortality 2 and long-term survival. 3 This is partially related to its late presentation especially in an elderly population affected by significant co-morbidity.…”

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confidence: 99%

Centralisation of Oesophagogastric Cancer Services: Can Specialist Units Deliver?

Forshaw¹,

Gossage²,

Stephens³

et al. 2006

annals

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INTRODUCTION Oesophagogastric cancer surgery is increasingly being performed in only centralised units. The aim of the study was to examine surgical outcomes and service delivery within a specialist unit.PATIENTS AND METHODS The case notes of all patients undergoing attempted oesophagogastrectomy between January 2000 and May 2003 were identified from a prospective consultant database. RESULTS A total of 187 patients (median age, 63 years; range, 29-83 years; M:F ratio, 3.9:1) underwent attempted oesophagogastrectomy. Of these, 91% were seen within 2 weeks of referral and treatment was instituted after a mean of 31 days (range, 1-109 days). More patients underwent surgery (63%) than neoadjuvant therapy (56%) within 1 month of referral. The main indication for surgery was invasive malignancy in 166 patients (89%). The 30-day mortality was 0.5% (1 death) and in-hospital mortality was 1.1% (2 deaths). The median length of hospital stay was 14 days (range, 7-69 days). Significant postoperative morbidity included: pulmonary complications (36%), cardiovascular complications (16%), wound infection (13%) and clinically significant anastomotic leaks (7%). Of the study group, 28 patients (15%) were admitted to ICU with a median stay of 10 days (range, 1-44 days); this accounted for 0.9% of ICU bed availability. Twelve patients (6.4%) were returned to theatre, most commonly for bleeding. The 1-year survival rates were 78%. During 2002-2003, national waiting list targets for both hernia repair and cholecystectomy were achieved.CONCLUSIONS Despite recent increases in workload, high volume specialist units can deliver an efficient and timely service with both good treatment outcomes and minimal impact upon elective surgical waiting lists and ICU provision.

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“…The most commonly used agents are cisplatin and fluorouracil, although some investigators incorporated vinca alkaloids or taxanes into their regimens. Clinical response rates of 40%-65%, pathological complete responses rates of 0%-10%, and resectability rates of 40%-80% were documented in some trials [31][32][33][34][35][36][37][38][39][40][41][42]. Median survival of these patients was reported to be 18-28 months [31][32][33][34][35][36][37][38][39][40][41][42][43].…”

Section: Neoadjuvant Chemotherapy With Surgery Versus Surgery Alonementioning

confidence: 99%

Multiple Management Modalities in Esophageal Cancer: Combined Modality Management Approaches

et al. 2004

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The overall success rate nationally in treating esophageal carcinomas remains poor, with over 90% of patients succumbing to the disease. In part I of this twopart series, we explored epidemiology, presentation and progression, work-up, and surgical approaches. In part II, we explore the promising suggestions of integrating chemotherapy and radiation therapy into the multimodal management of esophageal cancers.Alternative approaches to resection alone have been sought because of the overall poor survival rates of esophageal cancer patients, with failures occurring both localregionally and distantly. Concomitant chemotherapy and radiation therapy (XRT) have been shown, by randomized trial, to be more effective than XRT alone in treating unresectable esophageal cancers and also have shown promise as a neoadjuvant treatment when combined with surgery in the multimodal treatment of this disease. Various studies have also addressed issues such as preoperative chemotherapy, radiation dose escalation, chemotherapy/XRT as a definitive treatment versus use as a surgical adjuvant, and alternative chemotherapy regimens. There are suggestions of some progress, but this remains a difficult problem area in which management is continuing to evolve. The Oncologist 2004;9:147-159 The Oncologist 2004;9:147-159 www.TheOncologist.com Correspondence: Richard H. Matthews, M.D., Ph.D., Department of Radiation Oncology, Beth Israel/Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, USA. Telephone: 617-232-9500, ext 4457 or ext 5628; Fax: 617-524-0643; e-mail: RHMatthews@comcast.net Received August 15, 2003; accepted for publication November 19, 2003. ©AlphaMed Press 1083-7159/2004 INTRODUCTIONThe long-term outlook for esophageal cancer patients, traditionally treated by surgical approaches, has been bleak.

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Evaluation of pre- and postoperative chemotherapy for resectable adenocarcinoma of the esophagus or gastroesophageal junction.

Cited by 96 publications

References 0 publications

The accuracy of endoscopic ultrasound for restaging esophageal carcinoma after chemoradiation therapy

The accuracy of endoscopic ultrasound for restaging esophageal carcinoma after chemoradiation therapy

Centralisation of Oesophagogastric Cancer Services: Can Specialist Units Deliver?

Multiple Management Modalities in Esophageal Cancer: Combined Modality Management Approaches

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