Evaluation of PSF1 as a prognostic biomarker for prostate cancer

Tahara, H; Naito, Hisamichi; Kise, Kazuyoshi; Wakabayashi, Taku; Kamoi, Kazumi; Okihara, Koji; Yanagisawa, Akio; Nakai, Yasutomo; Nonomura, Norio; Morii, Eiichi; Miki, Tsuneharu; Takakura, Nobuyuki

doi:10.1038/pcan.2014.46

Cited by 20 publications

(14 citation statements)

References 31 publications

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“…GINS1 (also known as PSF1 ) is a subunit of the GINS (Go, lchi, Nii, San) complex which drives the unwinding of DNA in front of the replication fork [ 41 ]. Many studies have shown that GINS1 is up-regulated in several cancer types including lung, colon, prostate, colorectal and breast cancers [ 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. It is reported that GINS1 is expressed widely in early embryogenesis in mice, stem and progenitor cells, etc.…”

Section: Discussionmentioning

confidence: 99%

Identification of Key Pathways and Genes in the Dynamic Progression of HCC Based on WGCNA

Cai

Zhu

et al. 2018

Genes

147

127

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Hepatocellular carcinoma (HCC) is a devastating disease worldwide. Though many efforts have been made to elucidate the process of HCC, its molecular mechanisms of development remain elusive due to its complexity. To explore the stepwise carcinogenic process from pre-neoplastic lesions to the end stage of HCC, we employed weighted gene co-expression network analysis (WGCNA) which has been proved to be an effective method in many diseases to detect co-expressed modules and hub genes using eight pathological stages including normal, cirrhosis without HCC, cirrhosis, low-grade dysplastic, high-grade dysplastic, very early and early, advanced HCC and very advanced HCC. Among the eight consecutive pathological stages, five representative modules are selected to perform canonical pathway enrichment and upstream regulator analysis by using ingenuity pathway analysis (IPA) software. We found that cell cycle related biological processes were activated at four neoplastic stages, and the degree of activation of the cell cycle corresponded to the deterioration degree of HCC. The orange and yellow modules enriched in energy metabolism, especially oxidative metabolism, and the expression value of the genes decreased only at four neoplastic stages. The brown module, enriched in protein ubiquitination and ephrin receptor signaling pathways, correlated mainly with the very early stage of HCC. The darkred module, enriched in hepatic fibrosis/hepatic stellate cell activation, correlated with the cirrhotic stage only. The high degree hub genes were identified based on the protein-protein interaction (PPI) network and were verified by Kaplan-Meier survival analysis. The novel five high degree hub genes signature that was identified in our study may shed light on future prognostic and therapeutic approaches. Our study brings a new perspective to the understanding of the key pathways and genes in the dynamic changes of HCC progression. These findings shed light on further investigations.

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Section: Discussionmentioning

confidence: 99%

Identification of Key Pathways and Genes in the Dynamic Progression of HCC Based on WGCNA

Cai

Zhu

et al. 2018

Genes

147

127

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“…Its expression correlated with poor overall survival and progression-free survival in prostate cancer patients. 18 However, the impact of GINS1 in the pathogenesis of CRC is not well defined. Herein, we performed cell experiments in vivo and in vitro to determine GINS1 expression with the progression of CRC.…”

Section: Discussionmentioning

confidence: 99%

<p>Bioinformatics Analysis Identifies a Novel Role of <em>GINS1</em> Gene in Colorectal Cancer</p>

Bu¹,

Zhu²,

Zhu³

et al. 2020

CMAR

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“…Psf1 expression was found to be an independent prognostic marker for poor survival in NSCLC patients treated with surgery after preoperative chemotherapy or chemoradiotherapy (Kanzaki et al, 2016 ). Increased expression of Psf1 was associated with aggressiveness of hepatocellular carcinoma and prostate cancer (Tahara et al, 2015 ; Zhou et al, 2015 ). Overexpression of Psf2 was detected in intrahepatic cholangiocarcinoma, and tumorigenesis was promoted by elevated expression of Psf2 in early-stage cervical cancer (Obama et al, 2005 ; Ouyang et al, 2017 ).…”

Section: The Cmg As a Potential Target For Cancer Therapymentioning

confidence: 99%

The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy

Seo

Kang

2018

Front. Mol. Biosci.

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DNA helicases unwind or rearrange duplex DNA during replication, recombination and repair. Helicases of many pathogenic organisms such as viruses, bacteria, and protozoa have been studied as potential therapeutic targets to treat infectious diseases, and human DNA helicases as potential targets for anti-cancer therapy. DNA replication machineries perform essential tasks duplicating genome in every cell cycle, and one of the important functions of these machineries are played by DNA helicases. Replicative helicases are usually multi-subunit protein complexes, and the minimal complex active as eukaryotic replicative helicase is composed of 11 subunits, requiring a functional assembly of two subcomplexes and one protein. The hetero-hexameric MCM2-7 helicase is activated by forming a complex with Cdc45 and the hetero-tetrameric GINS complex; the Cdc45-Mcm2-7-GINS (CMG) complex. The CMG complex can be a potential target for a treatment of cancer and the feasibility of this replicative helicase as a therapeutic target has been tested recently. Several different strategies have been implemented and are under active investigations to interfere with helicase activity of the CMG complex. This review focuses on the molecular function of the CMG helicase during DNA replication and its relevance to cancers based on data published in the literature. In addition, current efforts made to identify small molecules inhibiting the CMG helicase to develop anti-cancer therapeutic strategies were summarized, with new perspectives to advance the discovery of the CMG-targeting drugs.

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Evaluation of PSF1 as a prognostic biomarker for prostate cancer

Abstract: PSF1 is expressed in high-grade prostate cancer and may be a useful biomarker to identify patients with a poor prognosis at the time of diagnosis.

Cited by 20 publications

References 31 publications

Identification of Key Pathways and Genes in the Dynamic Progression of HCC Based on WGCNA

Identification of Key Pathways and Genes in the Dynamic Progression of HCC Based on WGCNA

<p>Bioinformatics Analysis Identifies a Novel Role of <em>GINS1</em> Gene in Colorectal Cancer</p>

The Human Replicative Helicase, the CMG Complex, as a Target for Anti-cancer Therapy

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