Evaluation of radiolabeled curcumin-loaded solid lipid nanoparticles usage as an imaging agent in liver-spleen scintigraphy

Ayan, Arif Kürşad; Yenilmez, Ayse; Eroğlu, Hayrettin

doi:10.1016/j.msec.2017.02.114

Cited by 28 publications

(7 citation statements)

References 22 publications

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“…Several studies demonstrated that SLN nanocarriers have been used for oral delivery of bioactive plant compounds such as curcumin, quercetin, resveratrol, and especially essential oils. These natural phytochemicals have been widely used all over the world and their use is constantly enhancing due of the strong demand for pure natural ingredients in food and pharmaceutical industries ( Ayan et al, 2017 ; Comoglu et al, 2017 ; Couto et al, 2017 ). Burst release of plant bioactive compounds encapsulated in SLN nanoparticles in systemic conditions and internal environment of the body with different pH is one of the disadvantages of using these carriers ( Ramalingam et al, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Satureja khuzistanica Essential Oil-Loaded Solid Lipid Nanoparticles Modified With Chitosan-Folate: Evaluation of Encapsulation Efficiency, Cytotoxic and Pro-apoptotic Properties

2022

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The study aimed to synthesize Satureja khuzistanica essential oil-loaded SLN nanoparticles and to modify the surface of nanoparticles with folate-bound chitosan (SEO-SCF-NPs), and finally to investigate the effects of its toxicity and pro-apoptosis. For this purpose, the SEO-SLN nanoparticles were prepared using stearic acid, lecithin, tween 80, and water by high-pressure homogenization method. After characterization by FTIR, SEM, DLS, and ZETA potential methods, its toxicity effect against normal (HFF) and cancer (MCF-7) cells were evaluated by MTT assay. The occurrence of apoptosis in MCF-7 cells was assessed by flow cytometry and molecular analysis. The obtained results revealed the formation of round nanoparticles with a size of 279.40 nm, single dispersed (PDI: 0.3) and stable (ζ–potential: +31.69 mV). SEO-SCF-NPs indicated the effect of selective toxicity against MCF-7 cells (IC50: 88 μg/ml). Molecular analysis showed that SEO-SCF-NPs could inhibit cancer cells by activating the internal pathway of apoptosis as well as cell cycle disruption. Our finding suggests that SEO-SCF-NPs is a suitable candidate for preclinical cancer studies.

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Section: Discussionmentioning

confidence: 99%

Satureja khuzistanica Essential Oil-Loaded Solid Lipid Nanoparticles Modified With Chitosan-Folate: Evaluation of Encapsulation Efficiency, Cytotoxic and Pro-apoptotic Properties

2022

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“…In simulated gastrointestinal environments, the comparison between prepared SLNs and conventional SLNs formulated with organic solvents was performed in terms of stability. The outcomes of study exhibited a better physiochemical stability in terms of small particle size and improved stability in case of SLNs formulated from solvent free method in comparison to conventional formulations of SLNs [40].…”

Section: Solid-lipid Nanoparticles (Sln's)mentioning

confidence: 93%

A Review about various Nanomaterials in Drug Delivery Systems and their Applications

Brahamdutt¹,

Arun²,

Sangwan³

et al. 2018

IJRDPL

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Most of drug entities face the problems like reduced absorption, faster metabolism and elimination, toxicity because of drug distribution to other tissues, low drug solubility, unpredictable bioavailability, etc. These issues need to be work out so as to make the novel drug delivery systems for successful therapy. Use of nanotechnology is one of the promising strategies to overcome all of these problems. Distinctive properties of nanomaterials like smaller particles size, high surface area, and ease of suspending in liquids, deeper access across the cells and organelles, flexib le optical and magnetic properties are offered by nanoparticles as compared to other micro or macro sized particles. Nanomaterials can be classified into different categories based on their drug delivery system, dimensions, structure and consistency. Various types of nano-formulations (such as nanoparticles, nano-suspension, liposomes, hydrogels, solid lipid nanoparticles, dendrimers, microneedles, ocular insert/disk, transcorneal iontophoresis) have been used by the researchers for modulating the physicochemical properties and biological activities of the drugs. This review highlights the various types of nanomaterials with their advantages and applications in the pharmaceuticals for enhanced physicochemical properties and better biological activities with reduced toxicity and higher biocompatibility .

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“…Curcumin [28,29] β-carotene [30] Astaxanthin [31] Fucoxanthin [32] Theophylline [33] Caffeine [34,35] Vitamin B2 [36] www.videleaf.com…”

Section: Basic Structure Referencementioning

confidence: 99%

Developments in Encapsulation Techniques Based on Supercritical Fluids for Food Grade Bioactives

Klettenhammer¹,

Ferrentino²,

Morozova³

et al. 2021

Advances in Food Science

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In recent years, the demand for nutritive, functional and healthy foods has increased. This trend has induced food industry to investigate novel technologies able to produce ingredients with enhanced functional and physicochemical properties. Among these technologies, one of the most promising is the encapsulation based on supercritical fluids. Thanks to the inherent absence of organic solvent, the low temperature of the process to reach a supercritical state, and the capacity to dissolve lipid soluble bioactives, the encapsulation with supercritical carbon dioxide represents a green technology to produce several functional ingredients, with enhanced stability, high load, and tailored protection from environmental factors. Furthermore, from the fine-tuning of the process parameters like temperature, pressure and flow rate, the resulting functional ingredient can be easily designed to tailor the controlled release of the bioactive, or to reach specific levels of taste, odor and color. Accordingly, the aim of the present review is to summarize the state of the art of the techniques based on supercritical carbon dioxide for the encapsulation of bioactive compounds of food interest. Pros and cons of such techniques will be highlighted, giving emphasis to their innovative aspects that could be of interest for the food industry.

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Evaluation of radiolabeled curcumin-loaded solid lipid nanoparticles usage as an imaging agent in liver-spleen scintigraphy

Cited by 28 publications

References 22 publications

Satureja khuzistanica Essential Oil-Loaded Solid Lipid Nanoparticles Modified With Chitosan-Folate: Evaluation of Encapsulation Efficiency, Cytotoxic and Pro-apoptotic Properties

Satureja khuzistanica Essential Oil-Loaded Solid Lipid Nanoparticles Modified With Chitosan-Folate: Evaluation of Encapsulation Efficiency, Cytotoxic and Pro-apoptotic Properties

A Review about various Nanomaterials in Drug Delivery Systems and their Applications

Developments in Encapsulation Techniques Based on Supercritical Fluids for Food Grade Bioactives

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