Evaluation of relationship between the serum levels of inflammatory mediators and ocular injuries induced by sulfur mustard: Sardasht-Iran Cohort Study

Ghasemi, Hassan; Ghazanfari, Tooba; Yaraee, Roya; Ghassemi-Broumand, Mohammad; Soroush, Mohammad Reza; Pourfarzam, Shahryar; Masdari, Zahra; Faghihzadeh, Soghrat; Babaei, Mahmoud; Javadi, Mohammad Ali; Kiuchi, Yoshiaki; Naghizadeh, Mohammad Mehdi; Owlia, Parviz; Hassan, Zuhair Mohammad

doi:10.1016/j.intimp.2009.08.021

Cited by 28 publications

(14 citation statements)

References 36 publications

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“…It is conservative and directed at symptomatic relief, decreasing decreases ocular discomfort, and increases the quality of life in patients [Solberg et al, 1997;Javadi et al, 2005;Saladi et al, 2006;Baradaran-Rafii et al, 2011;Panahi et al, 2013]. Artificial tears without preservatives and lubricants are documented to be useful in the management of corneal epithelial defects and dry eye disease [Ghasemi et al, 2009b[Ghasemi et al, , 2013Kadar et al, 2013b;Fernandez et al, 2015;Simmons et al, 2015b]. Artificial tears and lubricants.…”

Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Panahi

Rajaee

Sahebkar

2017

J of Cellular Biochemistry

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Sulfur mustard (SM) is a strong blistering, highly reactive, lipophilic chemical war agent that causes injury in different organs including the skin, eyes, and respiratory tract. The Eyes are especially susceptible to the consequences of SM poisoning because of the aqueous and mucosal nature of conjunctiva and cornea. DNA alkylation and depletion of glutathione, are the most important mechanisms of SM action in the eye injuries. Acute clinical symptoms are including decrease in visual acuity, dryness, photophobia, blepharospasm, conjunctivitis, and complaints of foreign body sensation and soreness that gradually progress to severe ocular pain. Corneal abrasions, ulcerations, vesication, and perforations are common corneal consequences in SM injured victims. Appearance of chronic symptoms has been reported as chronic inflammation of the corneal and conjunctival vasculature, ischemia, lipid and cholesterol deposition, scarring in cornea, corneal thinning, opacification and perforation of the cornea, limbal stem cell deficiency (LSCD), and neovascularization. Different medical and surgical protocols have been documented in the management of SM-induced ocular injuries, including preservative-free artificial tears, topical steroids and antibiotic, mydriatic, antiglaucoma drops, therapeutic contact lenses, dark glasses and punctal plugs/cauterization, N-acetylcysteine, tarsorrhaphy, amniotic membrane transplantation, stem cell transplantation, and corneal transplantation. New drugs such as resolvin E1, topical form of essential fatty acids, thymosin β4, 43 amino-acid polypeptides, topical form of curcumin, newly formulated artificial tears, diquafosol, rebamipide, tretinoin, and oral uridineseems to be beneficial in the management of ocular lesion associated with sulfur mustard poisoning. Further studies are needed to approve these drugs in SM victims. J. Cell. Biochem. 118: 3549-3560, 2017. © 2017 Wiley Periodicals, Inc.

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Section: Management Of Delayed Ocular Complications Medical Managementsmentioning

confidence: 99%

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Panahi

Rajaee

Sahebkar

2017

J of Cellular Biochemistry

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“…Increased expression of β 1-integrin, the modulatory effect of macrophage/microglial cells, and enhancement of neurotrophic factor secretion, mediated by MSCs, might contribute to the induction of new vessels [115]. Other trophic factors secreted by MSCs which probably contributed to enhanced angiogenesis include VEGF, BDNF, IGF-1, bFGF, GDNF, and TGF [135, 158, 159]. In addition, it was found that the number of endothelial progenitor cells markered by CXCR4 was significantly increased in brain of adipose-derived MSC (Ad-MSC) treated ischemic rats.…”

Section: Mesenchymal Stem Cells (Mscs)mentioning

confidence: 99%

Stem Cell-Based Therapies for Ischemic Stroke

Liu¹,

Zou

Tian³

et al. 2014

BioMed Research International

190

158

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In recent years, stem cell-based approaches have attracted more attention from scientists and clinicians due to their possible therapeutical effect on stroke. Animal studies have demonstrated that the beneficial effects of stem cells including embryonic stem cells (ESCs), inducible pluripotent stem cells (iPSCs), neural stem cells (NSCs), and mesenchymal stem cell (MSCs) might be due to cell replacement, neuroprotection, endogenous neurogenesis, angiogenesis, and modulation on inflammation and immune response. Although several clinical studies have shown the high efficiency and safety of stem cell in stroke management, mainly MSCs, some issues regarding to cell homing, survival, tracking, safety, and optimal cell transplantation protocol, such as cell dose and time window, should be addressed. Undoubtably, stem cell-based gene therapy represents a novel potential therapeutic strategy for stroke in future.

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“…A 6-month treatment with gamma interferon, an anti-inflammatory effect via down-regulation transforming growth factor- β gene expression, is associated with an improvement in the lung function in sulfur mustard exposed patients with bronchiolitis [53]. However, recent studies showed that the serum levels of inflammatory cytokines such as IL-8, IL-6 [54], IL-1alpha, IL-1beta, and TNF-alpha, except for IL-1Ra and MMP-9 [55], decreased in SM-exposed subjects. More local studies on the lung are needed to clarify the exact role of this cytokines and inflammation.…”

Section: Discussionmentioning

confidence: 99%

The Role of Fas-FasL Signaling Pathway in Induction of Apoptosis in Patients with Sulfur Mustard-Induced Chronic Bronchiolitis

Pirzad

Jafari

Tavana

et al. 2010

Journal of Toxicology

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Sulfur mustard (SM) is an alkylating agent that induces apoptosis and necrosis in cells. Fas-Fas ligand (FasL) interaction could induce apoptosis as well. In this study, it was hypothesized that apoptosis might play an important role in the pathogenesis of SM-induced lung injury via Fas-FasL signaling pathway. In a case-control study, Fas and FasL levels, caspase-3 activity and percent of apoptotic cells were measured in bronchoalveolar lavage (BAL) fluid of patients 20 years after exposure to sulfur mustard and compared with the control group. Results show that Fas and FasL levels were significantly higher in BAL fluid cells in patients group compared with the control (P = .001). No significant differences were observed between mild and moderate-severe groups. BAL fluid cells caspase-3 activity was not significantly different among the mild, moderate-severe, and control groups. The data suggest that Fas-FasL-induced apoptosis was impaired in BAL fluid cells of SM-exposed patients which might be one of the initiators of pathogenesis in SM-induced lung injury in these patients.

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Evaluation of relationship between the serum levels of inflammatory mediators and ocular injuries induced by sulfur mustard: Sardasht-Iran Cohort Study

Cited by 28 publications

References 36 publications

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Ocular Effects of Sulfur Mustard and Therapeutic Approaches

Stem Cell-Based Therapies for Ischemic Stroke

The Role of Fas-FasL Signaling Pathway in Induction of Apoptosis in Patients with Sulfur Mustard-Induced Chronic Bronchiolitis

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