Evaluation of renal allografts function early after transplantation using intravoxel incoherent motion and arterial spin labeling MRI

Ren, Tong; Chen, Wen; Chen, Lihua; Xie, Shuangshuang; Cheng, Ying-Sheng; Fu, Yu; Oesingmann, Niels; Oliveira, André Fernando; Zuo, Panli; Yin, Jianzhong; Xia, Shuang; Shen, Wen

doi:10.1016/j.mri.2016.04.022

Cited by 61 publications

(59 citation statements)

References 29 publications

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“…DWI is a powerful MRI technique used for imaging molecular movement or diffusion that reflects changes in microstructure of biological tissues . Previous studies have confirmed that IVIM‐DWI can be used to assess renal function . However, renal pathology plays an important role in guiding therapy and follow‐up of CKD patients.…”

Section: Discussionmentioning

confidence: 99%

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Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Mao

Zhou

Zeng

et al. 2017

Magnetic Resonance Imaging

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Section: Discussionmentioning

confidence: 99%

“…IVIM‐DWI has been used to detect dysfunction of transplanted kidney in human studies, and evaluate renal fibrosis using animal models . Moreover, cortical D, D*, and f showed a positive correlation with estimated glomerular filtration rate (eGFR) in transplanted kidneys …”

mentioning

confidence: 99%

Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Mao

Zhou

Zeng

et al. 2017

Magnetic Resonance Imaging

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“…However, Artz et al [51] reported a poor reproducibility of medullar perfusion measurements in patients with transplanted kidneys. Perfusion measurements correlated positively with GFR values in recipients [54]. Moreover, combined measurements of RBF by ASL and GFR seem to be good predictors of loss of renal reserve in potential donors [55].…”

Section: Asl Mri In the Assessment Of Kidney Pathologiesmentioning

confidence: 99%

Renal Arterial Spin Labeling Magnetic Resonance Imaging

Becker

Rossi²

2016

Nephron

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Arterial spin labeling (ASL) MRI allows the quantification of tissue perfusion without administration of exogenous contrast agents. Patients with reduced renal function or other contraindications to Gadolinium-based contrast media may benefit from the non-invasive monitoring of tissue microcirculation. So far, only few studies have investigated the sensitivity, the specificity and the reliability of the ASL techniques for the assessment of renal perfusion. Moreover, only little is known about the interplay between ASL markers of perfusion and functional renal filtration parameters. In this editorial, we discuss the main technical issues related to the quantification of renal perfusion by ASL and, in particular, the latest results in patients with kidney disorders.

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“…Clinically, radiologists and nephrologists appreciate the utility of the DWI-MRI technique in assessing renal physiological or pathological changes. Previous studies have shown that the DWI technique is a sensitive method for detecting renal function in patients with chronic kidney disease [9], evaluating renal allografts function [10], assessing the severity of renal pathology, and guiding therapy for patients with CKD [11]. To the best of our knowledge, only two studies focused on the use of DWI-MRI in LN have been published.…”

Section: Introductionmentioning

confidence: 99%

Assessment of Renal Pathological Changes in Lupus Nephritis Using Diffusion Weighted Imaging: A Multiple Correspondence Analysis

Zhao

Yan

Jia

et al. 2018

Kidney Blood Press Res

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Background/Aims: Renal pathological changes affect the motion of water molecules, which can be detected using diffusion-weighted imaging (DWI). The current study was performed to explore the correlation between renal tissue pathological injuries and DWI iconographical parameters in lupus nephritis (LN). Methods: Twenty adult patients with LN and 11 healthy volunteers were recruited. Patients with LN received renal biopsies and renal DWI-MRI inspections. The renal biopsy tissues were characterized based on the ISN/RPS 2003 classification. The volunteers, who were of comparable gender and age, only underwent renal DWI-MRI inspection. Four DWI parameters, namely, apparent diffusion coefficient (ADC), pure diffusion coefficient (D_t), pseudo-diffusion coefficient (D_p), and perfusion fraction (f_p), were calculated using monoexponential and biexponential functions, respectively. Data from different renal areas and pathological pattern groups were compared. Multiple correspondence analysis (MCA) was performed to explore the correlation between each DWI index and multiple pathological features. Results: ADC, D_t, and f_p values were lower in the LN group compared to the controls (P < 0.001) regardless of the renal area in the cortex and medulla. D_p values were higher in the LN group (P = 0.004). A difference in mean DWI parameters was found between three LN subgroups and the healthy volunteers, with the exception of the D_p index in the renal cortex. MCA showed that serious proliferative pathological injuries and lower ADC and D_t values were located in the same quadrant. The MCA plots of D_p and f_p provided similar results. Higher D_p and f_p values were located in the MCA plot quadrant with more serious proliferative pathological changes. Conclusion: DWI is a noninvasive technique that may be used to detect renal pathophysiological changes. Renal cell proliferation and intestinal fibrosis may impact the movement of water in certain microenvironments. Enhanced perfusion may be a compensatory mechanism that is associated with renal pathological injuries.

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Evaluation of renal allografts function early after transplantation using intravoxel incoherent motion and arterial spin labeling MRI

Abstract: Combined IVIM and ASL MRI can better evaluate the diffusion and perfusion properties for allografts early after kidney transplantation.

Cited by 61 publications

References 29 publications

Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Chronic kidney disease: Pathological and functional evaluation with intravoxel incoherent motion diffusion‐weighted imaging

Renal Arterial Spin Labeling Magnetic Resonance Imaging

Assessment of Renal Pathological Changes in Lupus Nephritis Using Diffusion Weighted Imaging: A Multiple Correspondence Analysis

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