Evaluation of Renal Function in Children with Congenital Scoliosis and Congenital Anomalies of the Kidney and Urinary Tract

Abstract

BackgroundThe aim of this study was to compare renal function in children with congenital scoliosis and congenital anomalies of the kidney and urinary tract, with healthy children.Material/MethodsBiochemical tests were performed before surgery (pre-therapy) and after surgery (post-therapy) in 16 children with congenital scoliosis and congenital anomalies of the kidney and urinary tract. Thirty-two healthy children were matched for age, sex, and weight (healthy controls). General renal function tests included serum electrolytes, creatinine, urea, cystatin C, and estimated glomerular filtration rate (eGFR). Tests for early renal changes included N-acetyl-beta-D-glucosaminidase (NAG), urine microalbumin, serum transferrin, immunoglobulin G (IgG), urinary alpha-1-microglobulin (A1M), and beta-2-microglobulin (B2M).ResultsSixteen patients with congenital anomalies of the kidney and urinary tract included eight boys (mean age, 11.38±2.00 years) and eight girls (mean age, 11.00±2.78 years). There were no significant differences in renal function between the pre-therapy and post-therapy groups (P>0.05), or between the three groups (pre-therapy, post-therapy, and healthy controls). In the pre-therapy group, there were significant differences in IgG, A1M, NAG, and serum phosphate levels between boys and girls, urine microalbumin was significantly increased in girls, but not boys (P<0.05). There were no significant differences between the pre-therapy group and post-therapy group (P>0.05).ConclusionsRoutine tests of renal function were normal in children with congenital scoliosis and congenital anomalies of the kidney and urinary tract, but early changes in renal function occurred before surgical treatment, indicating long-term follow-up of renal function is recommended.

Improved renal function in neurofibromatosis type 1 patients

“…In contrast, Gao et al. reported that routine tests showed normal renal function in children with congenital scoliosis and congenital anomalies of the kidneys and urinary tract 23 . Therefore, the effects of scoliosis on renal function are controversial.…”

“…22 In contrast, Gao et al reported that routine tests showed normal renal function in children with congenital scoliosis and congenital anomalies of the kidneys and urinary tract. 23 Therefore, the effects of scoliosis on renal function are controversial. The present results indicated that renal function was superior in NF1 patients than in the controls even though the prevalence of scoliosis was significantly higher in the former than in the latter.…”

A targeted antibody-based array reveals a serum protein signature as biomarker for adolescent idiopathic scoliosis patients

“…Gao et al . found that the expression of B2M in the excreted urine was increased in the scoliosis children [ 21 ], and Suzuki et al . also found that increased excretion of B2M through urine in idiopathic scoliosis patients with urinary tract obstruction [ 22 ].…”

Treatment of Severe Congenital Scoliosis with Type ІI Respiratory Failure

“…3 Thus, respiratory damage, including respiratory failure (RF), is a well-recognised complication of severe congenital spinal deformity. 4 RF is divided into types I and II, the former only showing a reduction of partial pressure of arterial oxygen (PaO 2) , while the latter is characterised by PaO 2 <60 mmHg and PaCO 2 >50 mmHg. Untreated patients can suffer from acute RF due to the gradual reduction of respiratory volume, and the incidence and intraoperative and postoperative mortality rates are high.…”