Evaluation of retinal structure in unilateral amblyopia using spectral domain optical coherence tomography

Lekskul, Apatsa; Wuthisiri, Wadakarn; Padungkiatsagul, Tanyatuth

doi:10.1016/j.jaapos.2018.05.014

Cited by 16 publications

(17 citation statements)

References 16 publications

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“…Some recent studies on amblyopia paid attention to magnification effect; 4,10-12,30-32 however, most of them merely used statistical adjustment to adjust the effects of AL along with other clinical factors. 4,10,12,30,32 In the current study, AL was significantly shorter in amblyopic eyes compared with the nonamblyopic fellow eyes, emphasizing the importance of AL adjustment in identifying disease-specific abnormalities in the retinal structure. Therefore, we corrected the image magnification of scans using ImageJ when analyzing FAZ parameters and vessel densities.…”

Section: Discussionsupporting

confidence: 46%

“…35 Regarding macular thickness, previous studies have demonstrated conflicting results, with some investigations showing that the amblyopic eyes have increased macular thickness compared with fellow eyes, 1,2,36 or control eyes, 1,2,4,36 or no significant differences. 3,10,30 Our study demonstrated significantly greater overall macular thickness in amblyopic eyes compared with fellow eyes. Furthermore, analysis of the individual retinal layers showed that most inner retinal layers were thicker in amblyopic eyes, the previous reports on which have been somewhat inconsistent.…”

Section: Discussionmentioning

confidence: 54%

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Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses

Nishikawa

Chua

Kawaguchi

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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The purpose of this study was to characterize macular microvasculature and structural retinal layers using magnification-corrected optical coherence tomography angiography (OCTA) images in children with amblyopia. METHODS.This prospective cross-sectional study included 22 children with unilateral amblyopia (4-11 years of age) receiving spectral-domain OCTA. Vessel densities in foveal and parafoveal regions of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) were measured in amblyopic and fellow eyes using a customized image analysis program correcting the scale of retinal image with axial length. Iowa Reference Algorithms (Iowa Institute for Biomedical Imaging) were used to measure mean thickness values of 10 intra-retinal layers rescaled for image size correction. RESULTS.Foveal and parafoveal vessel densities in amblyopic eyes were lower than that of the fellow eyes in the SCP (fovea: P = 0.006 and parafovea: P = 0.003) and the DCP (P = 0.024 and P = 0.025, respectively). Amblyopic eyes had significantly smaller foveal avascular zone (FAZ) area than fellow eyes (P < 0.001). There were significant differences in retinal layer thickness between paired eyes, particularly in the inner retina in both foveal and parafoveal regions; retinal nerve fiber layer (RNFL) (P = 0.024 and P = 0.095, respectively), ganglion cell layer (P < 0.001 and P = 0.008), inner plexiform layer (IPL; P = 0.12 and P = 0.037), inner nuclear layer (P = 0.005 and P = 0.005), and outer plexiform layer (OPL; P = 0.02 and P = 0.057), except in the foveal IPL, the parafoveal RNFL, and OPL. CONCLUSIONS.Unilateral amblyopic eyes demonstrate reduced macular vessel density and thicker inner retinal layers compared with fellow eyes even after correcting for image magnification. Changes in macular microvasculature and structural layers may offer valuable insights in the development of amblyopia.

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Section: Discussionsupporting

confidence: 46%

Section: Discussionmentioning

confidence: 54%

Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses

Nishikawa

Chua

Kawaguchi

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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“…Unlike the macular vessel system, our data showed unchanged mean macular thickness in unilateral anisometropic amblyopes and in successfully treated anisometropic amblyopic children after adjustment for the AL. Many studies using OCT have examined retinal thickness of amblyopia and evaluated the reversal of difference after treatment with varied methodologies [33][34][35][36][37] . It is reported studies that showed difference in retinal thicknesses tend to show increased thickness associated with amblyopia.…”

Section: Discussionmentioning

confidence: 99%

Effect of amblyopia treatment on macular microvasculature in children with anisometropic amblyopia using optical coherence tomographic angiography

Zhang

Xie

Liu

et al. 2021

Sci Rep

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To measure the retinal microvascular density in patients with anisometropic amblyopia using optical coherence tomographic angiography (OCTA) and to evaluate the effects of successful amblyopia treatment on microvasculature in retina. 59 children (5–12 years old) including 22 newly diagnosed unilateral anisometropic amblyopia, 16 recovered unilateral anisometropic amblyopia, and 21 control children were imaged with OCTA using 6 × 6-mm macular scan pattern. Vessel densities of the superficial capillary plexus (SCP), the deep capillary plexus (DCP), and the overall macular thickness were acquired and compared among the three groups. After adjustment for axial length, the amblyopia group showed lower macular vessel density in the SCP (P = 0.005) and in the DCP (P = 0.004) compared with that of the control group. However, for the recovered amblyopia group, no difference of vessel density was found when compared with the control group in both the SCP (P = 0.548) and the DCP (P = 0.124). No difference of the mean macular thickness was found among three groups (P ≥ 0.15). Children with anisometropic amblyopia have reduced macular vessel density in OCTA, while no difference of macular vessel density was found between the recovered amblyopic and control eyes. Macular thickness showed no difference in anisometropic amblyopia and remained unchanged after amblyopic treatment.

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“…anizometropik, strabismik ve görsel yoksunluk ambliyopisi olan olguların ambliyopik ve normal gözleri arasında ortalama makula ve fovea kalınlıklarının benzer olduğunu bildirmişlerdir. 23 Benzer şekilde ülkemizde yapılan çalışmalardan Ulaş ve ark. hipermetropik anizometropik ambliyopili olgularda, Taşkıran Çömez ve ark.…”

Section: Gereç Ve Yöntemlerunclassified

Evaluation of Retinal Layers in Hyperopic Anisometropic Amblyopia by Optical Coherence Tomography Segmentation Analysis

Tekin¹,

İnanç²,

Kızıltoprak³

et al. 2020

Turkiye Klinikleri J Ophthalmol

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Evaluation of retinal structure in unilateral amblyopia using spectral domain optical coherence tomography

Cited by 16 publications

References 16 publications

Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses

Macular Microvasculature and Associated Retinal Layer Thickness in Pediatric Amblyopia: Magnification-Corrected Analyses

Effect of amblyopia treatment on macular microvasculature in children with anisometropic amblyopia using optical coherence tomographic angiography

Evaluation of Retinal Layers in Hyperopic Anisometropic Amblyopia by Optical Coherence Tomography Segmentation Analysis

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