Evaluation of robustly optimised intensity modulated proton therapy for nasopharyngeal carcinoma

Abstract

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Dose and robustness comparison of nominal, daily and accumulated doses for photon and proton treatment of sinonasal cancer

“…Although the effect of variations is not known until end of treatment, the good indications of accumulated target dose coverage and robustness in our study, suggest that a relaxed threshold for adaptation can be employed. Scandurra et al [39] reported similar results regarding robustness of proton plans but for nasopharyngeal carcinoma.…”

A review of the clinical introduction of 4D particle therapy research concepts

“…Motion management strategies in PT can be divided into passive and active techniques, depending on the patient’s breathing or whether the motion and beam delivery patterns are adjusted to each other or not. Passive motion management techniques encompass the ITV or margin-based approaches, (3D/4D) robust planning, rescanning and optimisation of the delivery sequences [34] , [82] , [83] , [84] , [85] , [86] , [87] ideally followed by a robust evaluation which serves for clinical decision-making [88] , [89] , [90] . Active motion management adjusts the beam delivery to the motion pattern potentially combined with the regulation of the patient’s breathing.…”

Proton Therapy for Squamous Cell Carcinoma of the Head and Neck: Early Clinical Experience and Current Challenges

“…Significant weight loss appeared to have the largest impact on grade 2 or higher xerostomia NTCP. The authors conclude that robustly optimized IMPT plans, in combination with volumetric verification imaging and adaptive planning, provide adequate target coverage and acceptable OAR dose variation [ 94 ]. The results of this series might not be generally translatable, given the fact that NPC patients might experience less weight loss compared to other HNC locations.…”