Evaluation of sentinel lymph nodes positive for melanoma for features predictive of non-sentinel nodal disease and patient prognosis: A 49 patient series

Wright, Eimear; Stanley, Paul; Roy, A.G.

doi:10.1016/j.bjps.2009.07.043

Cited by 10 publications

(6 citation statements)

References 7 publications

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“…Former studies reported metastatic NSLNs in 17% to 24% of the patients. [21][22][23][24] Accordingly, it appears to be important to identify a subgroup of patients with increased risk of affected NSLNs who stand to benefit from CLND. It would be just as desirable to avoid CLND in patients who are at low risk of further metastatic nodal disease.…”

Section: Discussionmentioning

confidence: 97%

“…It would be just as desirable to avoid CLND in patients who are at low risk of further metastatic nodal disease. 24 To identify predictive criteria for affected NSLN in CLND, we analyzed its association with a variety of patient and tumor characteristics in our data. For Breslow tumor thickness, a significant association with positive CLND status could be identified.…”

Section: Discussionmentioning

confidence: 99%

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Analysis of predictive factors for the outcome of complete lymph node dissection in melanoma patients with metastatic sentinel lymph nodes

Kunte¹,

Geimer²,

Baumert³

et al. 2011

Journal of the American Academy of Dermatology

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Analysis of predictive factors for the outcome of complete lymph node dissection in melanoma patients with metastatic sentinel lymph nodes

Kunte¹,

Geimer²,

Baumert³

et al. 2011

Journal of the American Academy of Dermatology

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“…Re-evaluation of earlier published classifications from other centers will be needed to validate the results, especially because the data reported in the published literature have been inconclusive with regard to the described classifications [8,36,27,31]. The reasons for the conflicting results are not clear.…”

Section: Discussionmentioning

confidence: 58%

Value of micromorphometric criteria of sentinel lymph node metastases in predicting further nonsentinel lymph node metastases in patients with melanoma

et al. 2011

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Patients with metastases in the sentinel node (SN) are advised to undergo complete lymph node dissection, although the majority of them will have no further metastatic disease. Some of these patients undergo unnecessary surgery. In this study, we tried to predict the likelihood of further non-SN metastases on the basis of earlier published micromorphometric classifications of SN metastases. Metastases in the SN were re-evaluated on the basis of the microanatomic location of the lesions according to the Dewar's criteria, the S-classification of SN, and tumor burden in accordance with the Rotterdam criteria. The results of these classifications were correlated with the presence of further non-SN metastases. Specimens of 124 positive-SN basins and subsequent complete lymph node dissection were investigated. Further metastases in non-SNs were found in 30 lymph node basins (24.2%). All of the above-mentioned classification systems were significantly correlated with non-SN tumor status. Especially, in patients with SN metastases in subcapsular location, a maximum depth of invasion of less than 0.3 mm (stage I according to the S-classification) or metastases of less than 0.1 mm in diameter had a very low probability of further non-SN metastases (0-5%). The validity of earlier published classifications of SN metastases-based on the micromorphometric criteria in predicting non-SN status was confirmed. Especially, in patients with subcapsular metastases, SI stage metastases or metastases of less than 0.1 mm had a very low risk of further non-SN metastases.

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“…O impacto das características microscópicas do GS na sobrevivência é controverso. Alguns autores demonstraram que o prognóstico dos doentes com BGS positiva correlaciona-se com características microscópicas tais como o diâmetro máximo do foco metastático, a localização intraganglionar da metástase, a extensão extracapsular e a invasão linfática [18][19][20][21] . A linfadenectomia positiva não esteve correlacionada com pior prognóstico, talvez devida a reduzida amostra que realizou linfadenectomia, no nosso estudo.…”

Section: Discussionunclassified

Biopsia De Gânglio Sentinela Em Portugal – Experiência De Um Centro De Referência

Teixeira

Vieira²,

Coutinho

et al. 2014

SPDV

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Introdução: A biopsia de gânglio sentinela é o método de escolha actual para o correcto estadiamento de doentes com melanoma cutâneo localizado. As guidelines do National Comprehensive Cancer Network (NCCN) reforçam o papel do status do gânglio sentinela como o factor de prognóstico mais importante na sobrevivência.Objectivos: Investigamos factores preditivos de gânglio sentinela positivo e factores que influenciam a sobrevivência na nossa população.Material e métodos: Realizámos um estudo retrospectivo de 221 doentes que foram submetidos a biopsia de gânglio sentinela durante o período entre 2004 e 2010 na Unidade de Cirurgia Dermatológica do Centro Hospitalar e Universitário de Coimbra. Foram aplicados métodos de análise estatística univariada e multivariada.Resultados: Os doentes do sexo feminino representavam 61% da população estudada e a idade média era de 59,3 anos. A maioria das lesões localizava-se nos membros inferiores (43%), sobretudo no pé (21,3% de todas as lesões). A biopsia de gânglio sentinela foi positiva em 48 casos (21,7%). A análise univariada determinou os seguintes factores preditivos de biopsia de gânglio sentinela positiva: sexo masculino, espessura de Breslow, tipo histológico e presença de infiltrado linfocítico. A análise multivariada confirmou o valor preditivo da espessura de Breslow e do infiltrado linfocítico. A taxa de sobrevivência aos 5 anos correspondia ao valor de 53,1% no grupo biopsia de gânglio sentinela positiva e 88,2% no grupo biopsia de gânglio sentinela negativa. A espessura de Breslow e o status do gânglio sentinela são factores independentes do prognóstico destes doentes.Conclusões: Os factores de risco para biopsia de gânglio sentinela positiva são consistentes com os dados da literatura. O status do gânglio sentinela permanece o principal determinante da sobrevivência, facto que reforça a relevância da biopsia de gânglio sentinela no estadiamento de doentes com esta neoplasia cutânea.

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Evaluation of sentinel lymph nodes positive for melanoma for features predictive of non-sentinel nodal disease and patient prognosis: A 49 patient series

Cited by 10 publications

References 7 publications

Analysis of predictive factors for the outcome of complete lymph node dissection in melanoma patients with metastatic sentinel lymph nodes

Analysis of predictive factors for the outcome of complete lymph node dissection in melanoma patients with metastatic sentinel lymph nodes

Value of micromorphometric criteria of sentinel lymph node metastases in predicting further nonsentinel lymph node metastases in patients with melanoma

Biopsia De Gânglio Sentinela Em Portugal – Experiência De Um Centro De Referência

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