Evaluation of serum endocan levels in relation to epicardial fat tissue thickness in metabolic syndrome patients

Abstract

IntroductionMetabolic syndrome has been recognized as a predictor of cardiovascular diseases. Epicardial fat tissue (EFT) thickness has recently been shown to be a predictor of cardiovascular diseases in metabolic syndrome patients. Endocan is a novel molecule which is considered to be an early marker of endothelial dysfunction. Our aim was to evaluate endocan serum levels for the first time in metabolic syndrome patients, in relation to EFT thickness.Material and methodsThe study included 44 patients with metabolic syndrome who had neither chronic kidney disease nor chronic inflammation and 26 healthy controls. Fasting blood samples were obtained from the groups. The serum levels of endocan were measured with a Sunred ELISA kit. EFT thickness of patients was measured by echocardiography.ResultsThe serum endocan levels were significantly lower in the metabolic syndrome patients compared to the healthy controls (120.71 ±90.17 pg/ml vs. 414.59 ±277.57, p < 0.001). Metabolic syndrome patients demonstrated significantly higher EFT (p = 0.042). EFT thickness had a positive correlation with age (r = 0.397, p = 0.008) and weight (r = 0.010). However, there was no correlation with serum endocan (r = –0.021, p = 0.893) or other parameters. Regression analysis revealed that waist circumference is the parameter among metabolic syndrome criteria having the strongest relationship with serum endocan levels ( = –0.499, p = 0.21).ConclusionsEFT thickness was high in metabolic syndrome patients and can be a useful marker for cardiovascular risk assessment. However, serum endocan levels were found to be low and there was no correlation with EFT thickness. Large sample sized prospective studies are needed to clarify the relation of endocan levels with the other clinical indicators of cardiovascular risk in metabolic syndrome.

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“…51 In contrast, an investigation of patients with metabolic syndrome showed a marked decrease in endocan levels in patients compared with controls, with no apparent correlation with epicardial fat tissue thickness. 52 CPAP is an effective treatment to reduce OSA symptoms, improve quality of life, and reduce the risk of long-term complications. Among our included studies, two studies have assessed the association between the endocan plasma levels after receiving CPAP.…”

“…51 In contrast, an investigation of patients with metabolic syndrome showed a marked decrease in endocan levels in patients compared with controls, with no apparent correlation with epicardial fat tissue thickness. 52…”

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