Evaluation of serum ferritin and some metal elements in type 2 diabetes mellitus patients: comparative cross-sectional study

Abstract

BackgroundThe chronic hyperglycemia of diabetes has been associated with an imbalance of some trace metal elements in the blood sample of type 2 diabetes patients.AimTo evaluate the status of serum ferritin and some selected metal elements among type 2 diabetes mellitus (T2DM) patients.MethodsFacility-based comparative cross-sectional study was conducted from February 15, 2015 to October 30, 2015, at Jimma University Specialized Hospital, Ethiopia. A total of 428 type 2 diabetes and nondiabetes study subjects were recruited to the study. After overnight fasting, 10 mL of venous blood samples were taken for biochemical and trace metal element analysis. Data were entered into EpiData version 3.5.1 and exported to SPSS version 20 for Windows for analysis.ResultsSerum concentration of Zn+2, Mg+2, Cr+3, ferritin, and Fe+3 in patients with type 2 diabetes was significantly lower (p<0.0001) than nondiabetes patients. In contrast, serum Cu+2 was significantly higher (p<0.0001) in type 2 diabetes patients than nondiabetics. In addition, significant differences were not seen in both groups with regard to serum Mn+2, Ca+2, and Po4−3. Waist-to-hip ratio (WHR), serum Fe+3, ferritin, and Mn+2 were significantly higher among oral hypoglycemic agent users of type 2 diabetes patients than the injectable insulin users. Serum Zn+2 had significant positive correlation with serum Mg+2 (r=0.738), Cr+3 (r=0.233), Ca+2 (r=0.238), and Po4−3 (r=0.222). In addition, serum Zn+2 had shown significant and negative correlation with body mass index (BMI, r=−0.331), WHR (r=−0.340), and fasting blood glucose (FBG, r=−0.186). Likewise, serum Mg+2 and Po4−3 are significantly and negatively correlated with BMI, WHR, and FBG.ConclusionThe imbalance of trace metal elements in the blood sample of diabetes is uncertain. Thus, we recommend a prospective cohort study to find out the principal factors behind the problem.

The Relationship between Dietary, Serum and Hair Levels of Minerals (Fe, Zn, Cu) and Glucose Metabolism Indices in Obese Type 2 Diabetic Patients

“…The relationship between T2DM and iron metabolism has gained interest both in research and clinical practice [ 15 , 56 ]. There was scientific evidence for the influence of elevated serum ferritin levels on IR and T2DM either because of increased body iron stores or due to inflammatory diseases [ 57 – 59 ].…”

Association of trace metal elements with lipid profiles in type 2 diabetes mellitus patients: a cross sectional study

“…Lastly, Fe +3 showed a negative correlation with TC. Iron plays an essential role as a cofactor for fuel oxidation and electron transport, but it also has the potential to cause oxidative damage if not carefully regulated [ 53 ]. Iron accumulation in the blood used as a biomarker for diabetes complication [ 54 – 56 ].…”

“…Iron accumulation in the blood used as a biomarker for diabetes complication [ 54 – 56 ]. Our earlier work [ 53 ] shows that the mean level of iron in type 2 diabetes patients was low as compared with normal healthy individuals. It actually deviates from the fact of many findings done on the relationship between diabetes and iron concentration in the blood.…”

Development of a Quantitative Scoring Method for Strobe Checklist

“…Following the development and piloting of the STROBE-M score checklist, we conducted a more formal evaluation of its inter-rater agreement. One reviewer (VL) selected 45 observational study publications (15 each from cross-sectional (23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37), cohort (38)(39)(40)(41)(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52), and case-control study (53-67) from ìPubMed databaseî published in the time period of 1 st March 2016 to 31 st May 2016 with the filters of English language, human studies, and full text availability. Irrelevant publications (opinion or critique of previous studies, letters to editors, meta-analysis were excluded (Fig.…”