Evaluation of Short Term Effect of Atorvastatin on Myocardial Performance and Its Pleiotropic Effects on Ischemic Heart Failure

El‐Sisi, Alaa E.; Hegazy, Sahar K; Ahmed, Mai; Hamouda, Manal Ali

doi:10.9734/bjpr/2015/17441

Cited by 1 publication

(1 citation statement)

References 37 publications

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“…In most of the included studies, serum oxLDL was measured using the enzyme-linked immunosorbent assay (ELISA) method. Thirteen studies used the Mercodia oxLDL kit (Mercodia, Uppsala, Sweden) [ 31 – 37 , 44 , 45 , 47 – 49 , 55 ], three studies used the SRL kit (Tokyo, Japan) [ 39 , 40 , 51 ], one study used the USCNK Life Science Inc. kit (Wuhan, China) [ 41 ], one study used the R&D Systems Inc. kit (Minneapolis, Minnesota, USA) [ 42 ], one study used the Immundiagnostik kit (Bensheim, Germany) [ 43 ], one study used the Kyowa Medex MX kit (Kyowa Medex, Inc., Tokyo) [ 50 ], one study used the Daiichi kit (Tokyo, Japan) [ 52 ], one study used the Biomedica kit (Wien, Austria) [ 57 ], one study used ML25 (monoclonal antibody against MDA-LDL) [ 54 ], and five studies did not mention the methods used or assay kits [ 38 , 46 , 53 , 56 , 58 ].…”

Section: Resultsmentioning

confidence: 99%

The Effects of Statin Therapy on Oxidized LDL and Its Antibodies: A Systematic Review and Meta-Analysis

Jamialahmadi

Baratzadeh

Reiner

et al. 2022

Oxidative Medicine and Cellular Longevity

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Background. Elevated serum low-density lipoproteins (LDL), the substrate for the formation of atherogenic oxidized LDLs (oxLDL), are a causal factor for atherosclerotic cardiovascular disease (ASCVD). Statins are well known to decrease LDL particle concentration and reduce ASCVD morbidity and mortality. Objective. To perform a meta-analysis of the effects of statins (i.e., type, dose, and duration of treatment) on serum levels of oxLDL and on immunoglobulin M (IgM) and immunoglobulin G (IgG) antibody levels against oxLDL. Methods. PubMed, Scopus, Embase, and Web of Science were searched up to February 5th, 2021, for randomized controlled trials (RCT) evaluating the effect of statins on oxLDL and anti-oxLDL antibody levels. Meta-analysis was performed using Comprehensive Meta-Analysis (CMA) V2 software. To evaluate the influence of each study on the overall effect size, a sensitivity analysis was performed using the leave-one-out method. Evaluation of the funnel plot, Begg’s rank correlation, and Egger’s weighted regression tests was used to assess the presence of publication bias in the meta-analysis. Results. A total of 28 RCTs including 4019 subjects were finally included in the meta-analysis. The results indicated a significant decrease in circulating concentrations of oxLDL after treatment with statins (SMD: -2.150, 95% CI: -2.640, -1.697, p < 0.001 ). Subgroup analysis found no significant effect of the intensity of statin treatment or statin lipophilicity on the reduction of circulating concentrations of oxLDL. An additional meta-analysis of 3 trials showed that statins did not change the serum levels of IgM and IgG antibodies to oxLDL. Conclusion. Statin therapy decreases serum oxLDL concentrations but does not affect circulating levels of anti-oxLDL antibodies.

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