“…Furthermore, reductions of the number of TH positive varicosity profiles in striatal subfields, after the injection of 8 µg of 6-OHDA, were described in our previous paper using a stereologic method for quantification (Rodrigues et al, 2001). These findings are in agreement with previous reports that have demonstrated decreases in the striatal dopamine levels and in the striatal TH immunoreactivity after a local injection of 6-OHDA (Lee et al, 1996;Kirik, Rosenblad, & Björklund, 1998;Chang, Wachtel, Young, & Kang, 1999;Barnéoud, Descombris, Aubin, & Abrous, 2000;Rosenblad et al, 2000). Our findings show that a decreased number of dopamine neurons in the ipsilateral VTA, after a single, unilateral injection of 6-OHDA in the striatum, are in full agreement with previous reports (Cadet & Zhu, 1992;Przedborski et al, 1995;Lee et al, 1996;Kirik et al, 1998).…”