Evaluation of some cellular immune index in HIV infected participants

Ifeanyichukwu, Martin; Onyenekwe, CC; Ele, PU; Ukibe, NK; Meludu, SC; Ezeani, Michael Chukwudi; Ezechukwu, CC; Amilo, GI; Umeanaeto, PU

doi:10.4314/ijbcs.v5i3.72169

Cited by 5 publications

(2 citation statements)

References 15 publications

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“…The reduced CD4 + T cell counts observed in HIV seropositives may be attributed to cell death caused by the HIV infection (Mark et al, 2005). Ifeanyichukwu et al, (2011) observed that the degree of T cell activation and rate of CD4 + T cell depletion in HIV infection appears to associate with the disease progression.…”

Section: Discussionmentioning

confidence: 98%

Evaluation of Pcv, Cd4+ T cell Counts, ESR and WBC Counts in Malaria Infected Symptomatic HIV (Stage 11) Male HIV/ Aids Subjects on Antiretroviral Therapy (Art) In Nnewi, South Eastern Nigeria

I.P¹

2012

iosrphr

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Section: Discussionmentioning

confidence: 98%

Evaluation of Pcv, Cd4+ T cell Counts, ESR and WBC Counts in Malaria Infected Symptomatic HIV (Stage 11) Male HIV/ Aids Subjects on Antiretroviral Therapy (Art) In Nnewi, South Eastern Nigeria

I.P¹

2012

iosrphr

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“…In spite of ongoing HIV/AIDS research and prevention methods, human immunodeficiency virus infection has persisted (Ifeanyichukwu et al, 2011). HIV infection has caused a considerable impact on cancer incidence since the global epidemic of AIDS (Carbone et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Biomarkers Associated with AIDS-Defining Malignancies in Children

C.P,

E.S.,

N.R.

et al. 2024

Int. J. Res. Publ. Rev.

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AIDs-infected children have an increased cancer risk due to a compromised immune system and an increased susceptibility to oncogenic viruses. Worldwide, a range of children between ages 0-14 years are infected with AIDs and are at an increased risk of developing cancer. However, as a result of immunosuppression, systemic inflammation, persistent HIV viremia and increased susceptibility to oncogenic viruses, children or peopl with AIDs are at a higher risk of some malignancies which includes those considered as AIDs-defining malignancies (ADM) such as Kaposi sarcoma and non-Hodgkin lymphoma and non-AIDs-defining malignancies (NADM) such as Hodgkin lymphoma. The intricate relationship between AIDS and malignancies in children involves a heightened cancer risk due to immunodeficiency. Biomarkers serve as crucial tools in identifying, understanding, and managing these malignancies by providing valuable information about the underlying biological processes and aiding in personalized treatment strategies.Combined antiretroviral therapy (cART) reduces the risk of cancer development in children infected with AIDs. Starting cART before the development of severe immunosuppression is key in the prevention of cancer in AIDs-infected children.Vaccination against high risk variants of human papilloma virus (HPV) may protect against cancer associated with HPV (e.g cervical cancer) later in life.

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The pattern of alpha-fetoprotein, CD4+ count, albumin, AST, ALT and ALP in HIV subjects on long term antiretroviral therapy in Nauth Nnewi, Anambra State, Nigeria

Ezeugwunne¹,

Ogbodo²,

Analike³

et al. 2021

IJFCM

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This study determined the pattern of alpha-fetoprotein, CD4 + count, albumin, AST, ALT and ALP in HIV positive subjects on long term antiretroviral therapy in NAUTH Nnewi, Anambra State, Nigeria. A total of ninety six (96) participants who were aged between 18 and 60 years attending the voluntary counseling and testing unit (VCT) and antiretroviral therapy unit (ART) of NnamdiAzikiwe University Teaching Hospital (NAUTH), Nnewi were randomly recruited for the study and grouped based on WHO criteria for HIV staging. Six millilitres (6mls) of blood sample were collected from each of the participants in each group and dispensed into EDTA and plain containers in appropriate volumes for the determination of the alpha fetoprotein (AFP), albumin (ALB), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and CD4+ count using standard laboratory methods. Results revealed no statistically significant differences in mean AFP levels, AST and ALP activities when compared between HIV positive participants on long term ART, short term ART, and HIV positive subjects not on ART and control groups respectively (p>0.05). Serum albumin concentration and ALT was not significantly different in HIV positive participants on long term ART than in those on short term ART (p>0.05) although serum albumin levels were significantly higher in HIV participants on long term ART and short term ART than in HIV positive subjects not on ART in each case (p<0.05) but was significantly lower in HIV positive participants not on ART compared to control subjects (p<0.05). CD4 + count was significantly higher in HIV positive participants on long term ART when compared with those o short term ART and HIV positive participants not on ART respectively (p<0.05). Therefore, this study has shown improved immune recovery with no hepatotoxicity in HIV positive persons on long term duration of antiretroviral therapy. Importantly, hypoalbuminemia existed among HIV positive subjects not on ART which is suggestive of further progression of the disease.

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Evaluation of some cellular immune index in HIV infected participants

Cited by 5 publications

References 15 publications

Evaluation of Pcv, Cd4+ T cell Counts, ESR and WBC Counts in Malaria Infected Symptomatic HIV (Stage 11) Male HIV/ Aids Subjects on Antiretroviral Therapy (Art) In Nnewi, South Eastern Nigeria

Evaluation of Pcv, Cd4+ T cell Counts, ESR and WBC Counts in Malaria Infected Symptomatic HIV (Stage 11) Male HIV/ Aids Subjects on Antiretroviral Therapy (Art) In Nnewi, South Eastern Nigeria

Biomarkers Associated with AIDS-Defining Malignancies in Children

The pattern of alpha-fetoprotein, CD4+ count, albumin, AST, ALT and ALP in HIV subjects on long term antiretroviral therapy in Nauth Nnewi, Anambra State, Nigeria

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