Evaluation of Some Renal Function Parameters in Rats Treated with Acrylamide

doi:10.20431/2455-2518.0201001

Cited by 2 publications

(1 citation statement)

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“…Acrylamide could be metabolized into a highly potent intermediate called glycidamide (Calleman et al, 1990;Sumner et al, 1992), which can undergo further conjugation reaction during phase two metabolism to less toxic more water-soluble metabolites that are excreted from the body in bile via the liver or in urine via the kidney (Airman et al, 2003). Both liver and kidney function bio markers have been reported to be significantly increased after exposure to acrylamide (Toker, 2016;Alwan et al, 2016); this was also observed in the present study. Some acrylamide molecules can form adduct with some vital macro molecules or generate free radicals in the cells, and since these organs have been directly involved in the metabolism, they become highly susceptible to the generated toxicities.…”

Section: Results Of Eleba On Tissues Of Liver and Kidney Histology In...supporting

confidence: 87%

ETHANOL EXTRACT OF Basella alba Linn MODULATES ACRYLAMIDE-INDUCED OXIDATIVE STRESS IN WISTAR RATS

Adewale

Samuel²,

Gbadegesin³

et al. 2022

J microb biotech food sci

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Acrylamide (AA), a common toxicant in processed foods is associated with cancer development via induction of oxidative stress. Therefore, the need for a potent antioxidant substance or compound that could ameliorate this toxic effect. Basella alba has been reported to have medicinal properties, and in this study, the anti-oxidative potentials of ethanol leaf extract of Basella alba (ELEBa) were assessed against oxidative stress induced by acrylamide in male Wistar rats (120-150g). Twenty (20) animals were grouped into four. Group 1: 1 ml/kg body weight (bwt.) distilled water (control), Group 2: 17.5 mg/kg bwt AA, Group 3: 17.5 mg/kg bwt AA+100 mg/kg bwt ELEBa, Group 4: 17.5 mg/kg bwt AA + 250 mg/kg bwt ELEBa. Treatment of animals was done orally and once daily for 14 days before sacrifice. The liver and kidney tissues were processed for the analyses of antioxidant activities. Serum was analyzed for hepatic and renal function bio markers in the treated animals. The plant’s bio active constituents were characterized by GC-MS. Acrylamide caused a significant (p < 0.05) ameliorated these values. GC/MS analysis revealed the presence of pentadecanoic acid, n‐hexadecanoic acid, cis‐13-octadecenoic acid, cis-vaccenic acid, oleic acid and octadecanoic acid. Our findings suggest that, ELEBa is a potential chemopreventive agent against acrylamide-induced oxidative stress in wistar rats.

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Section: Results Of Eleba On Tissues Of Liver and Kidney Histology In...supporting

confidence: 87%