Evaluation of substituted methyl cyclohexanone hybrids for anti-tubercular, anti-bacterial and anti-fungal activity: Facile syntheses under catalysis by ionic liquids

Ghatole, Ajay M.; Lanjewar, Kushal R.; Gaidhane, Mahesh K.; Hatzade, K. M.

doi:10.1016/j.saa.2015.06.035

Cited by 8 publications

(2 citation statements)

References 22 publications

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“…The newly synthesized compounds (3a-3i and 4a-4i) were tested for theirin vitro antimicrobial activity against clinical isolates of gram-positive bacteria S.Aureus, gram-negative bacteria E.coli and P. Aeruginosa, and the fungus C. Albicans. For all of the compounds, along with the standards for the bacteria, doxycycline, ampicillin, and fungi, fluconazole was used at a concentration of 100 µg/mL in DMSO as the solvent control and nutrient agar was used as the culture method [26][27][28][29]. After 24h of incubation at 37 °C, the zones of inhibition were measured in mm.…”

Section: In Vitro Antibacterial and Antifungal Activitymentioning

confidence: 99%

Innovational combination of hetero-bifunctional N-PEG quinoline scaffolds derivatives with improved anticancer activity against breast and colon cancer cell lines and P-glycoprotein, cytochrome p450 enzyme activity prediction

Gaidhane¹,

Ghatole²,

Lanjewar³

et al. 2020

Turk J Chem

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Polyethylene glycol (PEG) is a polymer that is widely used as a carrier for drug delivery systems (DDS). A library of N-PEGylated quinoline derivatives of PEG molecular weight 200 was prepared rapidly after the activation of PEGs using maleic anhydride. Quinoline with a polymer backbone is essential as new material. PEG is a water-soluble nonionic polymer approved by food and drug organizations for medicine applications. Because of its nontoxic grapheme, it is widely utilized in numerous biochemical, cosmetic, pharmaceutical, and industrialized applications. The modern SwissADME is a web tool that stretches free admittance to a pool of hasty, yet solid, clarifying models for physicochemical properties, pharmacokinetics, and therapeutic science. The present facile synthetic strategy can be a practical approach for incorporating polymeric carriers conjugated with drug moieties, either in the backbone of the polymer or as a terminal and pendant group on the polymer chains.

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Section: In Vitro Antibacterial and Antifungal Activitymentioning

confidence: 99%

Innovational combination of hetero-bifunctional N-PEG quinoline scaffolds derivatives with improved anticancer activity against breast and colon cancer cell lines and P-glycoprotein, cytochrome p450 enzyme activity prediction

Gaidhane¹,

Ghatole²,

Lanjewar³

et al. 2020

Turk J Chem

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show abstract

“…N- Unsubstituted 2-aminoimidazole exhibited similar properties (lower nucleophilicity of exocyclic aminogroup than endocyclic reaction centers) in the reactions with aromatic aldehydes and different CH-acids (dimedone, barbituric acid), but instead of cyclic products the treatments yielded Michael adducts (with participation of CH-center in the position 3; Andriushchenko et al, 2013 ). On the other hand, the formation of Mannich bases in the similar reactions involving 2-aminothiazole indicates on the higher reactivity of its exocyclic NH 2 -group in comparison with the endocyclic nucleophilic centers (Ghatole et al, 2015 ).…”

Section: Main Partmentioning

confidence: 99%