Evaluation of Subtle Left Ventricular Systolic Abnormalities in Adult Patients with Hypertrophic Cardiomyopathy

Left atrial function and phenotypes in asymmetric hypertrophic cardiomyopathy

“…34,35 However, strain rate, although only assessed longitudinally, was not helpful in discriminating the different clinical subgroups in our study. 34,35 However, strain rate, although only assessed longitudinally, was not helpful in discriminating the different clinical subgroups in our study.…”

“…31,32 Our study adds to the literature an analysis between the different atrial and ventricular metrics in the perspective of different HCM phe- Strain rate measures are potentially a more load independent measures and could theoretically provide complementary diagnostic information in patients with HCM. 34,35 However, strain rate, although only assessed longitudinally, was not helpful in discriminating the different clinical subgroups in our study. A possible explanation is that SR is more susceptible to measurement error.…”

Diagnosis and management of hypertrophic cardiomyopathy

“…Owing to a number of complex mechanisms involving also abnormal dissociation of actin and myosin filaments during the active phase of relaxation in early diastolic filling and LV myocardial properties, HCM is often associated with diastolic dysfunction (12) . Decreased tissue Doppler indices-systolic annular velocities and increased E/E′ are typical findings for this (13) . In pre-phenotypic gene-positive HCM, the E/E′ ratio has been described as a marker that can distinguish those individuals from controls (14) .…”

“…Additionally, the increased wall thickness results in augmented radial wall thickening and overestimation of ventricular systolic function ( 71 , 72 ). There are suggestions that LV torsion and strain imaging may detect global subtle dysfunction even when traditional measurements are normal (13) .…”

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“…Owing to a number of complex mechanisms involving also abnormal dissociation of actin and myosin filaments during the active phase of relaxation in early diastolic filling and LV myocardial properties, HCM is often associated with diastolic dysfunction (12). Decreased tissue Doppler indices-systolic annular velocities and increased E/E 0 are typical findings for this (13). In pre-phenotypic gene-positive HCM, the E/E 0 ratio has been described as a marker that can distinguish those individuals from controls (14).…”