Evaluation of the adverse effects of subcutaneous carprofen over six days in healthy cats

Steagall, Paulo V.; Moutinho, Flávio Quaresma; Mantovani, Fernanda; Passarelli, D.; Thomassian, Armen

doi:10.1016/j.rvsc.2008.04.002

Cited by 12 publications

(11 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…O grupo controle negativo recebeu o mesmo volume do veículo utilizado para diluir o extrato (água destilada, 10 mL/kg), e o controle positivo recebeu indometacina (10 mg/kg, via oral). A indometacina é um anti-inflamatório não esteroidal, que possui potente atividade analgésica e anti-inflamatória, inibindo a transmissão nociceptiva, além da prevenção do edema e da inflamação (Steagall et al, 2009).…”

Section: Methodsunclassified

Atividades antinociceptiva e antiinflamatória do extrato etanólico de Luehea divaricata

Batista

Trindade

Lira

et al. 2016

Rev. bras. plantas med.

View full text Add to dashboard Cite

Recebido para publicação em 15/07/2015 Aceito para publicação em 12/04/2016 RESUMO: Considerando os diferentes usos etnofarmacológicos apresentados pela planta Luehea divaricata, realizou-se este estudo com o objetivo de avaliar as atividades antinociceptiva e antinflamatória do extrato etanólico de suas folhas, em modelo animal, nas dosagens de 20, 40, 80 e 160 mg/Kg, por via oral. Foram realizados os seguintes testes: contorções abdominais induzidas pelo acido acético, placa quente, formalina e edema de pata induzido por carragenina. Foram utilizados camundongos Swiss (20-25 g) para os três primeiros testes e ratos Wistar (180-250 g), para o último, divididos em seis grupos de oito animais, totalizando 48 animais em cada parâmetro de avaliação. Os resultados foram analisados estatisticamente pela análise de variância a 5% de probabilidade, para verificar quais os tratamentos que diferiram entre si, e estes foram submetidos aos testes de Kruskall-Wallis e Student-Newman-Keuls. O extrato etanólico das folhas de L. divaricata (EEtOH-Ld), nas diferentes doses estudadas, apresentou significativa atividade antinociceptiva sobre a dor induzida quimicamente por injeções intraperitoneal de acido acético e intraplantar de formalina. Na dosagem de 160 mg/Kg, esse extrato apresentou ação analgésica central, aos 120 minutos de observação, no teste de placa quente e reduziu o edema de pata induzido pela administração de carragenina, uma hora após a administração do agente inflamatório, semelhante ao efeito produzido pelo fármaco padrão. Palavras-chave: açoita-cavalo, dor, plantas medicinais.ABSTRACT: Antinociceptive and anti-inflammatory activities of Luehea divaricate ethanol extract. Considering the different ethnopharmacological uses submitted by the plant Luehea divaricata, this study took place in order to evaluate the antinociceptive and anti-inflammatory activities of the ethanol extract of the leaves in an animal model, the dosages of 20, 40, 80 and 160 mg/kg by oral intake. The following tests were performed: writhing induced by acetic acid, hot plate, formalin, and paw edema induced by carrageenan. Swiss mice (20-25 g) were used for the first three tests and Wistar rats (180-250 g) for the last, divided into six groups, each of eight animals, totaling 48 animals for each assessment parameter. The results were statistically analyzed by analysis of variance at 5% probability to verify which treatments differ, and these were tested by Kruskal-Wallis and Student-Newman-Keuls. The ethanol extract of L. divaricataleaves (EEtOH-Ld) at the different studied doses showed significant antinociceptive activity on chemically induced pain by intraperitoneal injections of acetic acid and intraplantar formalin. At a dosage of 160 mg/kg, this extract showed a central analgesic action after 120 minutes of observation in the hot plate test and reduced action in the paw edema induced by carrageenan one hour after the administration of the inflammatory agent, similar to the effect produced by the standard drug.

show abstract

Section: Methodsunclassified

Atividades antinociceptiva e antiinflamatória do extrato etanólico de Luehea divaricata

Batista

Trindade

Lira

et al. 2016

Rev. bras. plantas med.

View full text Add to dashboard Cite

show abstract

“…Although this patient also received dexamethasone and flunixin meglumine, they were administered after the onset of clinical signs; therefore, their administration was not thought to contribute to duodenal perforation. In contrast, a safety study reported no adverse effects in 7 healthy cats administered subcutaneous carprofen at 4 mg/kg once daily …”

Section: Introductionmentioning

confidence: 95%

“…Elimination of carprofen occurs primarily by biotransformation into glucuronide metabolites within the liver . Cats have reduced glucuronidation enzyme activity decreasing their ability to metabolize carprofen.…”

Section: Introductionmentioning

confidence: 99%

“…2 Elimination of carprofen occurs primarily by biotransformation into glucuronide metabolites within the liver. 3 Cats have reduced glucuronidation enzyme activity decreasing their ability to metabolize carprofen. The elimination halflife is approximately 18-20 hours in the cat, [4][5][6] whereas the half-life in dogs is approximately 8-12 hours.…”

Section: Introductionmentioning

confidence: 99%

“…In contrast, a safety study reported no adverse effects in 7 healthy cats administered subcutaneous carprofen at 4 mg/kg once daily. 3 Treatment of NSAID overdose typically consists of gastrointestinal decontamination (GID) using a combination of emesis and activated charcoal (AC). 9,10 These decontamination methods have been proven to cause a reduction in plasma carprofen concentration.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations