Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents

González-Trujano, Ma. Eva; Peña, Esteban; Martı́nez, Ana; Moreno, Julia; Guevara-Fefer, Patricia; Déciga-Campos, Myrna; López‐Muñoz, Francisco

doi:10.1016/j.jep.2006.12.011

Cited by 131 publications

(77 citation statements)

References 30 publications

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“…The membranes were suspended in Tris-EDTA buffer, filtered and resuspended in 0.1% sodium dodecyl sulfate (SDS) in PBS (with 0.02% sodium azide). The suspension of membrane antigens was dialyzed for 48 h against 0.1% SDS in PBS at room temperature and stored at 4 °C (Gonzalez ET Al., 2007).…”

Section: Preparation Of Hemoglobin-free Sheep Red Blood Cell Membranementioning

confidence: 99%

“…Rosmarinus officinalis L. commonly referred to as rosemary (Oluwatuyi ET Al., 2004) is a plant belonging to Labiatae (Lamiaceae) family (Haloui ET Al., 2000). Rosmarinus officinalis L. is an evergreen, perennial aromatic shrub (Gonzalez ET Al., 2007& Orhan ET Al., 2008, reaching a height of 1.5 m (Atti-Santos ET , native to the chalky, calcareous hills along the Mediterranean Sea (Oluwatuyi ET Al., 2004). It is well known as a common spice and household plant widely used around the world for medicinal purposes.…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Sheyab¹,

Abuharfeil²,

Salloum

et al. 2012

JBLS

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The hypolipidemic activity of leaves of rosemary (Rosmarinus officinalis), a herbal plant was studied. Three groups of BALB/c mice were treated as following: the first group was fed with normal diet (sugar & water), the second group was fed with high cholesterol (HC) (2% by weight) and coconut oil (25% by weight), for 36 days, and the third group was fed with HC diet and given 100 mg/kg rosemary extract (10% w/v) during the last 15 days of treatment period. There was a significant decrease (P < 0.001) in plasma total cholesterol (TC)(-68.57%), low density lipoprotein (LDL) (-56.34%), and triglycerides (TG) (-182.61%). A significant increase in high density lipoprotein (HDL) (38.53%) was obtained in rosemary-fed mice compared to HC mice. In another experiment, the immunomodulatory activity of aqueous extract of R. officinalis was evaluated in BALB/c mice. Mice were treated with three doses of extract (10, 50, 100 mg/kg body weight) for 8 weeks. Humoral immunity against membrane proteins of sheep erythrocytes measured by ELISA showed that IgM (Immunoglobulin M) response significantly increased by 26.95%, 36.5%, 70.78% respectively, in mice fed with 10, 50, and 100 mg/kg of rosemary as compared to the control group (P < 0.05). IgG (Immunoglobulin G) response increased significantly at all antibody titers, in mice fed with rosemary at doses of 10, 50, and 100 mg/kg. Meanwhile, there was no significant different in IgM and IgG responses between 50 and 100 mg/kg (P > 0.05). On the other hand, concanavalin A-stimulated proliferation of spleen cells from mice fed with 100 mg rosemary extract was significantly higher by 57% than that of cells from the corresponding control animals.

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Section: Preparation Of Hemoglobin-free Sheep Red Blood Cell Membranementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Sheyab¹,

Abuharfeil²,

Salloum

et al. 2012

JBLS

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“…Their ability to reduce oxidative damage in diabetes has been demonstrated. 33,61,62 R. officinalis (Rosemary) has been examined for its antioxidant potential and is now recognized as one of medicinal plant species with the highest antioxidant activity. 8 Moreover, in folk medicine, Rosemary is one of the plants used to combat DM in Lebanon.…”

mentioning

confidence: 99%

Designing monographs for Rosmarinus officinalis L. and Lavandula angustifolia L.: Two Lebanese species with significant medicinal potentials

Koleilat¹,

Raafat²,

El-Lakany³

et al. 2017

Phcog J

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Introduction:The world health organization recommends validating medicinal plants to ensure safety and efficacy. Lavandula is valued for the production of essential oil used in aromatherapy. Rosmarinus is known for its folk use as anti-oxidant and antidiabetic. This study aims to design monographs for Rosmarinus officinalis (Linn.) and Lavandula angustifolia (Linn.) cultivated, in conditions similar to their natural habitat, at Beirut Arab University botanical garden. Also screening the antioxidant activity of both plants, and assessing the antidiabetic effect of R. officinalis (Linn.). Methods: macroscopic and microscopic examination, hydrodistillation to obtain essential oils (EOs), thin layer chromatography, Gas chromatography-Mass spectrometry, and physiochemical properties of the EOs were determined. The antioxidant effect of the EOs is determined by DPPH assay. The antidiabetic effect of Rosemary EO is investigated using alloxan-induced diabetic mice. Results: the qualities of studied species are in agreement with the standards described in WHO monographs and in the British pharmacopeia. Composition of the EO produced from either Rosemary (REO) or Lavender (LEO) collected at different months showed differences. The EO of both showed significant antioxidant effects in DPPH assay (p<0.05). In vivo investigation of the antidiabetic effect of REO showed a significant antidiabetic effect in diabetic mouse model (p<0.05). Conclusion: both plant species and their EOs fulfilled most of standards specified by the British Pharmacopeia 2013. Rosemary collected in April (Spring) showed the best antioxidant activity. Lavender collected in September (Early Fall) showed the best antioxidant activity. REO revealed significant lowering in blood glucose level at the dose of 110 mg/kg.

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“…It is often cultivated for its great quantity of essential oils used in the perfume industry and as a flavoring agent. Rosemary has been widely used in traditional medicines and it has been found to have significant antioxidant activity [50]. It has long been known as the herb of remembrance [51], and it has been reported that memory is improved with the use of R. officinalis [52,53].…”

Section: Rosmarinus Officinalismentioning

confidence: 99%

A Review Study on the Traditional Plants has Potential Antidepressant Property

Rahman¹

2017

MOJCSR

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DiscussionThis review includes detailed description of antidepressant activity of 21 medicinal plants whose roots, leaves, fruits extracts were used to evaluate the activity from various research articles.The tests employed for antidepressant activity includes HBT, FST, TST, OFT, EPMT, and MACT using rotarod and THB. These tests are employed with slight modification from original method, keeping basic concept same. HBTExploratory behaviour of rodents such as mice is evaluated using hole board test. The floor of the apparatus has regularly arranged holes. The animal is placed in the arena. Both frequency and duration of spontaneous elicited hole-poking behavior are then measured during a short period of time. This test also provides a simple method for assessing anxious response of a rodent to an unfamiliar environment. The use of the hole-board in this perspective relies on the hypothesis that the behavior of animals exposed to a novel situation results from competition AbstractDepression refers to a state of low mood and aversion to activity characterized by depressed mood, loss of interest, reduced energy and concentration. The reasons for the disease include stimulation of MAO-A, inhibition of NA and 5-HT. Symptoms include the diminished interest of pleasure, feelings of worthlessness or inappropriate guilt, a decrease in appetite and libido, insomnia, and recurrent thoughts of death or suicide. There are plenty of synthetic drugs used to treat depression but not enough blissful for patients, moreover, these synthetic drugs have potential side effects. After decades of serious obsession with the modern medicinal system, people have started looking at the ancient healing systems like Ayurveda, Siddha, and Unani. Many scientists are researching plant material for treating this disorder and there are lots of publications on it. But this is not sufficient for treating depression; further outcome should come into light that's the purpose of our review.

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Evaluation of the antinociceptive effect of Rosmarinus officinalis L. using three different experimental models in rodents

Cited by 131 publications

References 30 publications

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

The Effect of Rosemary (Rosmarinus officinalis. L) Plant Extracts on the Immune Response and Lipid Profile in Mice

Designing monographs for Rosmarinus officinalis L. and Lavandula angustifolia L.: Two Lebanese species with significant medicinal potentials

A Review Study on the Traditional Plants has Potential Antidepressant Property

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