“…5,20 Fractional thermal injury of dermal collagen induces a vigorous wound healing process leading to inflammatory cascade and stimulates new collagen, elastin, and hyaluronic acid formation, eventually resulting in dermal remodeling. 5,20 Furthermore, skin needling with microneedles has been reported to stimulate migration and proliferation of keratinocytes and fibroblasts by inducing the release of several growth factors. 5,20,21 And, untreated areas which are located between treated areas serve as a reservoir of cells that promote and accelerate wound healing.…”