Evaluation of the Correlation Between Childhood Asthma and Helicobacter pylori in Kashan

Abstract

Background:Asthma is a chronic inflammatory air-way disease with increasing prevalence rate during the recent years. There are studies about the relationship between asthma and infectious diseases, including the association between asthma and Helicobacter pylori. According to the latest studies, there is an epidemiological correlation between asthma prevalence and prevalence of H. pylori.Objectives:The aim of this research was to study the correlation between H. pylori and asthma by biopsy in five to eighteen year-old children who had undergone endoscopy at Shahid Beheshti Hospital.Patients and Methods:Three hundred children (5 to 18 years old) undergoing endoscopy owing to gastro-intestinal problems at Shahid Beheshti Hospital were observed for childhood asthma using the Gina 2010 questionnaire which included 24 questions with “yes” and “no” answers to identify asthmatic patients with five positive answers. Next, the patients were referred to an allergy and asthma specialist for clinical examinations, spirometry and post bronchodilator test (Post BD).Results:Among 138 H. pylori positive patients, eight cases (5.8 %) were asthmatic while of the 162 H. pylori negative patients 28 (17.3%) were asthmatic. This difference was statistically significant (P Value = 0.002). The correlation between H. pylori and asthma was studied after controlling the confounding variables including, gender, age and family history. The results obtained for the above-mentioned variables were significant (P Values of 0.004, 0.005 and 0.002, and Odd-Ratio Mantel Haenszel (ORMH) of 3.38, 3.24 and 4.06, respectively).Conclusions:Our findings showed that there is an inverse correlation between H. pylori and asthma. Performing more studies with larger sample sizes is necessary to confirm these results.

Helicobacter pylori in relation to asthma and allergy modified by abdominal obesity: The HUNT study in Norway

“…A potential inverse relationship between H. pylori and asthma and allergy has been widely reported, although the results are controversial 20, 21, 22, 23, 24, 25. In the largest meta-analysis including 19 studies, 9 an inverse association between H. pylori and asthma was demonstrated based on nine cross-sectional studies (pooled OR 0.84, 95% CI 0.74–0.96), but the pooled OR was not statistically significant in seven case-control studies (pooled OR 0.82, 95% CI 0.53–1.27) or three prospective cohort studies (pooled OR 0.82, 95% CI 0.53–1.27).…”

Helicobacter pylori-Mediated Protection from Allergy Is Associated with IL-10-Secreting Peripheral Blood Regulatory T Cells

“…A meta-analysis of 700 cases and 785 controls could not prove a link between H. pylori infection and asthma risk ( 25 ), and some researchers remain skeptical ( 26 ). The most consistently observed protective associations with asthma and atopy, however, are in children ( 8 , 16 , 18 , 20 , 24 , 27 ).…”

Evaluation of <i>Helicobacter pylori</i> Infection in Asthmatic Children and Its Relationship With Severity of the Disease

“…Also there was no significant relationship between sex and age of children with H.pylori infection, but in the cases with more severity of asthma, there was, lower the prevalence of H.pylori infection [27]. In another study by Khamechian et al, 2015, on children aged 5 to 18 years who underwent endoscopy. Prevalence of asthma was lower in children with H.pylori infection [28].…”

“…в 2015 г. [28] на детях в возрасте от 5 до 18 лет, прошедших эндоскопию. Распространённость астмы была ниже у детей с инфекцией H.pylori.…”