Evaluation of the diuretic effects of crude stem bark extraction of Zanthoxylum heitzii (Rutaceae) in Wistar rats

Ntchapda, Fidèle; Kakesse, Maguirgue; Fokam, Michel Archange Tagne; Pancha, Olivier Mbouemboue; Abakar, Djedouboum; Dimo, Théophile

doi:10.1016/s2095-4964(15)60188-1

Cited by 7 publications

(3 citation statements)

References 18 publications

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“…Its fruits are used in Cameroon and the Democratic Republic of Congo as spices. Different parts of Z. heitzii are also used in African folk medicine to treat hypertension, gonorrhea, malaria, and cardiac disorders [ 15 , 17 ]. Previous investigations have reported the antimicrobial activities of the bark of Z. heitzii ; its fruits have also been reported to have beneficial effects against sickle cell diseases [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…Chemical studies also had isolated and characterized a variety of active compounds from the bark of Z. heitzii [ 18 ]. Recently, meso-2,3-bis(3,4,5-trimethoxybenzyl)-1,4-butanediol and 4-acetoxy-2,3-bis(3,4,5-trimethoxybenzyl)-1-butanol, two alkaloids, and triterpenes were isolated from the bark of Z. heitzii and characterized [ 17 ]. Previously, its antiproliferative and antilarvicidal properties were reported [ 16 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

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Zanthoxylum heitzii Modulates Ferric Nitrilotriacetate‐Dependent Oxidative Alterations in Four Vital Organs: An In Vitro Organoprotective Model

Essogo

Moukette

Tankeu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Ferric nitrilotriacetate (Fe-NTA) is a highly reactive compound used to induce degenerative disorders through oxidative stress (OS). Zanthoxylum heitzii (Z. heitzii) is a spice used as a medicinal plant to treat a variety of illnesses. This study investigated the ability of extracts from the leaves, fruits, roots, and barks of Z. Heitzii to inhibit Fe-NTA mediated oxidative damage in rats. The supernatant of rat liver homogenates was pretreated with the extracts for one hour before the induction of oxidative damage using a solution of Fe-NTA (400 mM). The activities of superoxide dismutase (SOD), catalase, and peroxidases were measured together with the marker of lipid peroxidation and the level of glutathione. The pretreated groups showed a significant increase in the activity of SOD, catalase, and peroxidases. The methanolic extract from the leaves of Z. heitzii (36.78 ± 3.30) and aqueous extract from the fruits (37.01 ± 2.52) showed the highest activities of SOD in the liver. The lowest concentration of MDA was found in the liver, and the glutathione was greater in the brain. Conclusively, these results suggest that Z. heitzii might be a chemoprotector which may be used in for prevention of distinct types of diseases induced by oxidative stress.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Zanthoxylum heitzii Modulates Ferric Nitrilotriacetate‐Dependent Oxidative Alterations in Four Vital Organs: An In Vitro Organoprotective Model

Essogo

Moukette

Tankeu

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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show abstract

“…Diuretic drugs are important in the treatment of several cardiovascular and renal diseases such as hypertension, heart failure, eclampsia, nephritis and chronic renal failure [1,2] . They contribute to the regulation of blood pressure, promoting significant urinary excretion of water and electrolytes (sodium, potassium, chlorure), decreasing blood volume and peripheral resistance [3]. Their renoprotective effects also result in removal of metabolite of protein and toxic substances [4] .…”

Section: Introductionmentioning

confidence: 99%

Comparative effects of aqueuos extract of Phyllanthus amarus and its fractions on urinary excretion in rat

Yao¹,

Kamagaté²,

Amonkan³

et al. 2016

J Phytopharmacol

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The aim of the present study was to compare the effect of Phyllanthus amarus extracts and its fractions on urinary excretion. Aqueous extract of Phyllanthus amarus was prepared by decoction of the whole plant and lyophilized. Ethanolic fraction and chloroformic fraction of Phyllanthus amarus were obtained from aqueous extract. Animal were divided into 5 groups of 6 rats and placed individually in metabolic cages. The control group received normal water. A positive control group received furosemide (5 mg/kg, i.p.), used as a reference loop diuretic drug. Three other groups were treated with aqueous extract or ethanolic fraction or chloroformic fraction of Phyllanthus amarus by intraperitoneal injection at the same dose of 40 mg/kg. Urine volumes were collected each 2 h during 8 h period. The diuretic action was obtained by a ratio of urinary excretion of treated group and that of control group. Phyllanthus amarus extracts increased urinary excretion. This effect was time dependant and significant, compared to control group (p < 0.001). During all experiments, ethanolic fraction increased urinary excretion, more than other extracts. After 8h period, it had eliminated about 2.44 ± 0.27 mL, however this value remained less than that of furosemide (3.01 ± 0.17 mL). The urinary excretion induced by furosemide was significantly high (p < 0.05), compared to ethanolic fraction, but the ratio was similar. This study showed that, like furosemide, ethanolic fraction seemed to be the most potent extract for diuresis. Further studies might be carried out to identify the actives molecules and its mechanisms.

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Molecular networking and collision cross section prediction for structural isomer and unknown compound identification in plant metabolomics: a case study applied to Zhanthoxylum heitzii extracts

et al. 2022

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Evaluation of the diuretic effects of crude stem bark extraction of Zanthoxylum heitzii (Rutaceae) in Wistar rats

Cited by 7 publications

References 18 publications

Zanthoxylum heitzii Modulates Ferric Nitrilotriacetate‐Dependent Oxidative Alterations in Four Vital Organs: An In Vitro Organoprotective Model

Zanthoxylum heitzii Modulates Ferric Nitrilotriacetate‐Dependent Oxidative Alterations in Four Vital Organs: An In Vitro Organoprotective Model

Comparative effects of aqueuos extract of Phyllanthus amarus and its fractions on urinary excretion in rat

Molecular networking and collision cross section prediction for structural isomer and unknown compound identification in plant metabolomics: a case study applied to Zhanthoxylum heitzii extracts

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