Evaluation of the effect of alpha-tocopherol on anxiety and the neuroinflammatory process during alcohol withdrawal in a model of forced and chronic self-administration of liquid diet containing ethanol: Behavioral and neurochemical evidence

Boas, Gustavo Roberto Villas; Paes, Marina Meirelles; Cunha, Mila Silva; Ponsoni, Luis Felipe; Silveira, Ana Paula Stefanello da; Oesterreich, Silvia Aparecida

doi:10.1016/j.alcohol.2022.08.002

Cited by 5 publications

(3 citation statements)

References 73 publications

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“…Withdrawal causes a neuroinflammatory response which increases anxiety. Villas Boas et al [66] conducted a study with male Wistar rats divided into four groups and subjected to a forced and chronic rehabilitation procedure, involving a liquid diet containing 6 and 8% ethanol for 15 days, followed by an abrupt interruption of treatment. The results showed that α-tocopherol showed anxiolytic action and anti-inflammatory activity, attenuating the anxious behavior of abstinent animals and reducing neuroinflammation in amygdaloid nuclei (AN) and medial hypothalamic nucleus (mHN); and the intensity of the anxiolytic and anti-inflammatory effect of α-tocopherol is dose-dependent.…”

Section: Vitamin E As a Neuroprotectormentioning

confidence: 99%

“…The results showed that α-tocopherol showed anxiolytic action and anti-inflammatory activity, attenuating the anxious behavior of abstinent animals and reducing neuroinflammation in amygdaloid nuclei (AN) and medial hypothalamic nucleus (mHN); and the intensity of the anxiolytic and anti-inflammatory effect of α-tocopherol is dose-dependent. [66].…”

Section: Vitamin E As a Neuroprotectormentioning

confidence: 99%

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The importance of vitamin E in cardiovascular health

Kimi Uehara,

Ramalho,

Teresa Bento

2024

The Power of Antioxidants - Unleashing Nature's Defense Against Oxidative Stress [Working Title]

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Vitamin E (VE) is the main antioxidant of the cell membrane. Research has extensively explored the use of VE in preventing or treating diseases associated with oxidative stress in humans, with a particular emphasis on cardiovascular diseases (CVD). Studies suggest a range of effects beyond its well-established antioxidant action, including anti-inflammatory, immunomodulatory, lipid-lowering, anticoagulant, antidiabetic, and neuroprotective properties. Regarding the effects of VE on the prevention or treatment of CVD and cardiovascular outcomes, the studies showed conflicting results. The benefits of VE were suggested as: (1) the inverse association between increased intake of VE and the risk of stroke, (2) reduced CVD mortality rate, (3) increased glutathione and reduced C-reactive protein, malondialdehyde, LDL, and blood pressure, (4) lower risk of CVD and metabolic syndrome with higher intake of VE, and (5) lower systolic blood pressure. However, a positive association between VE supplementation and diastolic blood pressure was observed. Other adverse effects of VE supplementation have been suggested, such as an increased risk of hemorrhagic stroke and a small but significant increase in the risk of hospitalization in patients with heart failure. Therefore, it is not possible to recommend VE supplementation for the prevention and treatment of CVD.

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Section: Vitamin E As a Neuroprotectormentioning

confidence: 99%

Section: Vitamin E As a Neuroprotectormentioning

confidence: 99%

The importance of vitamin E in cardiovascular health

Kimi Uehara,

Ramalho,

Teresa Bento

2024

The Power of Antioxidants - Unleashing Nature's Defense Against Oxidative Stress [Working Title]

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“…There are different scales and assessment instruments used to measure anxiety levels in patients experiencing alcohol withdrawal. In general, anxiety symptoms can be mild, moderate or severe and may include feelings of nervousness, restlessness, excessive worry, difficulty concentrating, muscle tension and irritability, among others [5]. In some more serious cases, alcohol withdrawal can lead to more intense anxiety and can even evolve into generalized anxiety disorder [6].…”

Section: Introductionmentioning

confidence: 99%

An Evaluation of the Anxiolytic Potential of Amentoflavone in Adult Zebrafish Undergoing Alcohol Withdrawal: In Vivo and In Silico Studies

Frota,

da Silva,

Alves

et al. 2024

Receptors

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The constant use of alcoholic beverages can deregulate serotonin levels, affecting neurotransmitters and triggering symptoms of anxiety. In this context, the objective of this work was to evaluate the anxiolytic potential and possible action mechanisms of the natural compound amentoflavone against the deleterious effects caused by alcohol withdrawal on the behavior of adult zebrafish (aZF). The experiments showed that amentoflavone did not change locomotion and did not cause toxicity in aZF during up to 96 h of analysis, with a median lethal concentration (LC50) greater than 1.0 mg/mL. The reversal of anxiety by pretreatment with granisetron suggested that the anxiolytic effect of amentoflavone is dependent on serotonergic 5-HT3A/3B receptors. Furthermore, amentoflavone reversed anxiety due to flumazenil pretreatment, suggesting a dependence on the GABAA receptor. The three concentrations of amentoflavone tested were effective in treating anxiety resulting from alcohol withdrawal. In silico analysis validated the in vivo results, supporting the idea that the interaction of amentoflavone with the protein occurs in a more stable manner than reference compounds. Amid growing interest in natural alternatives to treat anxiety disorders, amentoflavone is a potential candidate for a new anxiolytic compound that acts specifically on the 5HT3A/3B and GABAergic serotonergic pathways.

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