Evaluation of the efficacy and tolerability of miglitol in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylureas

Abstract

The objective of this study is to examine the efficacy and tolerability of miglitol with respect to improving glycemic control in Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylurea treatment. This was a randomized, double-blinded, placebo-controlled, multicenter study. A total of 105 patients were randomized to receive 24 weeks of treatment with miglitol (n = 52; titrated from 50 mg to 100 mg 3 times daily) or placebo (n = 53). Concomitant sulfonylurea treatment and diet remained unchanged. The primary endpoint was change in glycated hemoglobin (HbA1c) from baseline at 24 weeks. Secondary endpoints were changes in fasting plasma glucose (FPG), postprandial plasma glucose (PPG), and postprandial serum insulin (PSI). The miglitol treatment group showed significantly greater reductions in HbA1c and PPG levels compared with the placebo group. With respect to adverse events, abdominal discomfort, diarrhea, and hypoglycemia occurred with similar frequency in both groups. Results of this study indicate that miglitol significantly improves metabolic control in Chinese patients with type 2 diabetes mellitus. Miglitol is safe and well tolerated, with the exception of abdominal discomfort. Therefore, miglitol may be a useful adjuvant therapy for Chinese patients with type 2 diabetes mellitus inadequately controlled by diet and sulfonylurea treatment.

Miglitol administered before breakfast increased plasma active glucagon-like peptide-1 (GLP-1) levels after lunch in patients with type 2 diabetes treated with sitagliptin

“…Miglitol is an aGI, which improves postprandial hyperglycemia [4,5]. In general, aGIs should be taken just before meals [6].…”

The α-Glucosidase and α-Amylase Enzyme Inhibitory of Hydroxytyrosol and Oleuropein

“…Several in vitro and in vivo studies have shown that oleuropein and its derivate hydroxytyrosol possess a wide range of biochemical and pharmacological properties 7 . It was also reported that ble state in diabetes 9 . In fact, the inhibitory activity of oleuropein s aglycon and luteolin glucosides luteolin-7-O-β-glucoside and luteolin-4 -O-β-glucoside against pancreatic amylase were determined 8 .…”

Antidiabetic effects of natural plant extracts via inhibition of carbohydrate hydrolysis enzymes with emphasis on pancreatic alpha amylase

“…Although their safety and tolerability has been widely evaluated due to the common clinical use of these drugs, their lack of specificity has been seen to produce several gastrointestinal side effects like abdominal cramping, flatulence and diarrhea (171)(172)(173)(174). Natural alpha-glucosidase and alpha-amylase inhibitors are being investigated as new candidates to control hyperglycemia in diabetic patients, but few data are available regarding the negative effects they might produce.…”