Evaluation of the Greenness, Whiteness, and blueness profiles of stability indicating HPLC method for determination of Denaverine hydrochloride and benzyl alcohol in pharmaceuticals

Habib, Neven M.; Tony, Rehab Moussa; AlSalem, Huda Salem; Algethami, Faisal K.; Gamal, Mohammed

doi:10.1016/j.microc.2024.110733

Microchemical Journal

2024

DOI: 10.1016/j.microc.2024.110733

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Evaluation of the Greenness, Whiteness, and blueness profiles of stability indicating HPLC method for determination of Denaverine hydrochloride and benzyl alcohol in pharmaceuticals

Neven M. Habib,

Rehab Moussa Tony,

Huda Salem AlSalem

et al.

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Cited by 7 publications

References 47 publications

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A sustainable RP‐HPLC method for concurrent estimation of capecitabine and celecoxib in liposomal formulation: Greenness and whiteness appraisal

Shewale,

Gomte,

Jain

2024

Archiv der Pharmazie

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Liposomes have been reported for combination therapy due to their ability to carry both hydrophilic and lipophilic drugs together. The current investigation aims to develop a novel, eco‐friendly, and sustainable reverse‐phase high‐performance liquid chromatography (RP‐HPLC) method for the simultaneous quantification of capecitabine and celecoxib co‐encapsulated in liposomes. The method reported herein uses a C18 column (4.6 × 250 mm2, 5 μm) and a mobile phase consisting of water, and acetonitrile/methanol in a ratio of 60:40, containing 0.1% formic acid in both the phases. The flow rate is maintained at 1 mL/min, with an injection volume of 10 μL in the gradient mode. Detection is set at λmax = 240 nm for capecitabine and 252 nm for celecoxib. The developed liposomes are mono‐disperse with a surface potential of −6.93 mV. The average size of the liposomes is 142 nm. The percentage entrapment efficiency for capecitabine is 52.39 ± 0.94%, and for celecoxib, it is 77.13 ± 0.74%. The Analytical Greenness Metric of 0.61 and Analytical Eco‐Scale Score of 75 signify the greenness of the developed method. Also, the Red‐Green‐Blue model shows excellent whiteness, with a score of 83.2. Thus, the developed method offers a reliable, accurate, precise, buffer‐free, and environment‐friendly RP‐HPLC approach for the simultaneous analysis of capecitabine and celecoxib co‐encapsulated in liposomes.

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A sustainable RP‐HPLC method for concurrent estimation of capecitabine and celecoxib in liposomal formulation: Greenness and whiteness appraisal

Shewale,

Gomte,

Jain

2024

Archiv der Pharmazie

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Assessing environmental sustainability of HPLC methods for tri-combination anti-hypertensive drug analysis

Yenduri

2025

Green Analytical Chemistry

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Sustainable quantification of glycopyrronium, indacaterol, and mometasone along with two genotoxic impurities in a recently approved fixed-dose breezhaler formulations and biological fluids: A machine learning-augmented UV-spectroscopic approach

Abbas,

Gamal,

Naguib

et al. 2024

Microchemical Journal

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Evaluation of the Greenness, Whiteness, and blueness profiles of stability indicating HPLC method for determination of Denaverine hydrochloride and benzyl alcohol in pharmaceuticals

Cited by 7 publications

References 47 publications

A sustainable RP‐HPLC method for concurrent estimation of capecitabine and celecoxib in liposomal formulation: Greenness and whiteness appraisal

A sustainable RP‐HPLC method for concurrent estimation of capecitabine and celecoxib in liposomal formulation: Greenness and whiteness appraisal

Assessing environmental sustainability of HPLC methods for tri-combination anti-hypertensive drug analysis

Sustainable quantification of glycopyrronium, indacaterol, and mometasone along with two genotoxic impurities in a recently approved fixed-dose breezhaler formulations and biological fluids: A machine learning-augmented UV-spectroscopic approach

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