Evaluation of the hematologic system as a marker of subclinical inflammation in hyperemesis gravidarum: a case control study

Abstract

Objectives: Current evidence suggests that subclinical inflammation plays a significant role in the development of hyperemesis gravidarum (HEG). Simple hematological markers, such as mean platelet volume (MPV), neutrophil-to-lymphocyte ratio (NLR), and platelet-to-lymphocyte ratio (PLR), have been shown to reflect inflammatory burden and disease activity in several disorders. This study aimed to determine the diagnostic value of these hematological parameters for HEG. Material and methods:A total of 54 HEG patients and 58 age-and gestational-age-matched control subjects were studied. NLR, MPV, PLR, platelet distribution width (PDW), and red cell distribution width (RDW) values in all patients were calculated and recorded from complete blood cell counts.Results: For HEG patients, the median NLR was 3.2 (1.6-7.1), and the median PLR was 143.7 (78.1-334.6); for control subjects, the values were 2.1 (1.0-4.7) and 93.1 (47.3-194.7), respectively. Although both the NLR and PLR of HEG patients were found to be significantly higher than in the controls, no significant difference was found between the study groups in terms of MPV, RDW, or PDW. Correlation analysis revealed a significant correlation between NLR and CRP (r = 0.872, p < 0.001). Conclusions:Our results show that peripheral blood NLR and PLR values can reflect inflammatory burden in HEG patients and can be used as markers for HEG.

Subclinical inflammation markers in hyperemesis gravidarum and ketonuria: A case–control study

“…[161718] Several studies evaluating the significance of inflammation markers in HEG have been presented. [1213] Although the relationship between HEG and inflammation markers has been investigated previously, our study is unique due to its inclusion of the relationship between inflammation markers and ketonuria. [12] The results pertaining to ketonuria from this study may lead to prospective randomized trials of ketonuria in patients with HEG and provide objective discharge criteria, which are missing in the literature and clinical practice for HEG patients.…”

“…[2324] Beyazit et al . [12] found that PDW and MPV did not differ significantly between HEG patients and controls. Tayfur et al .…”

“…[91011] Several studies evaluating the significance of inflammation markers in HEG have been presented. [1213] However, the results are conflicting and the relationship between the severity of ketonuria and subclinical inflammation has not been examined. In this study, we aimed to investigate the diagnostic value of inflammation markers and the relationship between ketonuria severity and inflammation markers in HEG patients.…”

Red blood cell distribution width in pregnancy: a systematic review

“…RDW was tested also in the evaluation of hyperemesis gravidarum (HEG), a medical condition of intractable vomiting during pregnancy affecting approximately 0.3 - 2% of all pregnancies ( 36 ). The study was performed in 54 HEG patients and 58 age- and gestational-age-matched controls, but no statistically significantly differences with RDW-CV were detected (12.1% ± 1.4 vs. 12.6% ± 1.7, P > 0.05)…”

Dipeptidyl Peptidase-4 Inhibitors and Inflammation: Dpp-4 Inhibitors Improve Mean Pleatelet Volume and Gamma Glutamyl Transferase Level

“…Perhaps the worst aspect of diabetes is the systemic inflammation and oxidative stress and they are almost accused of being the real reasons underlying many complications of diabetes [14] [15] [16]. MPV is now well known as a predictor of inflammation and has been shown in many cases as a marker of inflammation [17] [18] [19]. In our previous research, we have shown that we can use MPV in the diagnosis of uveitis and venous thrombosis in patients with Behçet's syndrome [20] [21].…”