Evaluation of the hepatoprotective activity of hydroalcoholic extract of Alhagi camelorum against valproic acid-induced hepatotoxicity in rats

Iqbal, Muhammad Omer; Manzoor, Majid; Mumtaz, Asad; Riaz, Romana; Arshad, Shafia; Khan, Imran; Manzoor, Zahid; Munawar, Shaukat Hussain; Andleeb, Saiqa; Ahmed, Muhammad Masood; Aslam, Aqsa

doi:10.1016/j.biopha.2022.112953

Cited by 13 publications

(4 citation statements)

References 29 publications

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“…[4,9] It has been observed to cause oxidative stress in tissues by oxidant/antioxidant imbalance, trigger inflammatory reactions, and autoimmune reactions. [2,10] Therefore, conducting research on compounds that can counteract the adverse effects of VA has become important. The various pharmacological effects of M. oleifera leaves have been demonstrated to come from its abundant active components like flavonoids and polyphenols.…”

Section: Resultsmentioning

confidence: 99%

“…Although it has been reported to prevent the growth of salivary gland tumors, [5] VA has some clinical side effects including sialadenosis and dry mouth [4,9] . It has been observed to cause oxidative stress in tissues by oxidant/antioxidant imbalance, trigger inflammatory reactions, and autoimmune reactions [2,10] . Therefore, conducting research on compounds that can counteract the adverse effects of VA has become important.…”

Section: Resultsmentioning

confidence: 99%

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Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Cergel,

Tuzuner,

Turkyilmaz

et al. 2024

Chemistry & Biodiversity

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This study aimed to explore the potential protective impacts of Moringa oleifera extract on major alteration in salivary glands of rats exposed to sodium valproate (VA). Groups were defined as control, control + moringa extract, sodium valproate, and sodium valproate + moringa extract. Antioxidant and oxidant status, activities of digestive and metabolic enzymes were examined. VA treatment led to various biochemical changes in the salivary glands, including decreased levels of antioxidants like glutathione, glutathione‐S‐transferase, and superoxide dismutase (except for sublingual superoxide dismutase). Conversely, a decrease in alpha‐amylase, alkaline and acid phosphatase, lactate dehydrogenase, protease, and maltase activities were observed. The study also demonstrated that VA induces oxidative stress, increases lipid peroxidation, sialic acid, and nitric oxide levels in the salivary glands. Total oxidant capacity was raised in all glands except in the sublingual gland. The electrophoretic patterns of proteins were similar. Moringa oleifera extract exhibited protective properties, reversing these VA‐induced biochemical changes due to its antioxidant and therapeutic attributes. This research suggests that moringa extract might serve as an alternative treatment approach for individuals using VA and experiencing salivary gland issues, although further research is necessary to confirm these findings in human subjects.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Cergel,

Tuzuner,

Turkyilmaz

et al. 2024

Chemistry & Biodiversity

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“…The Wistar male rats acclimatized in the animal house were randomly grouped into 7 groups, with each group having 6 rats (42 Wistar rats) per experiment (n = 3, meaning 126 animals for the whole study). Animals were orally dosed with CCl 4 as mentioned previously [ 22 , 23 ], and other respective concentrations of TA extracts (30, 40, and 50 mg/kg b.w.) using gastric gavage without the administration of any anesthesia agent.…”

Section: Methodsmentioning

confidence: 99%

Tamarix articulata Induced Prevention of Hepatotoxicity Effects of In Vivo Carbon Tetrachloride by Modulating Pro-Inflammatory Serum and Antioxidant Enzymes to Reverse the Liver Fibrosis

et al. 2022

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This study evaluates the hepatoprotective activity of a Tamarix articulata extract against carbon tetrachloride-mediated hepatotoxicity in Wistar rats. Our results demonstrated that the oral administration of Tamarix articulata extract (50 mg/kg b. w) significantly restored the serum levels of liver enzymes and antioxidant parameters (superoxide dismutase, catalase, glutathione reductase, and thiobarbituric reactive substances). Histopathology analysis revealed that Tamarix articulata extract significantly reduced hepatic fibrosis by inhibiting the necrosis of hepatocytes. Furthermore, serum pro-inflammatory (tumor necrosis factor-alpha, tumor growth factor-beta, and interleukin-6) markers were significantly restored. However, the anti-inflammatory cytokine adiponectin levels increased to normal levels in the group treated with Tamarix articulata extract. Additionally, we observed diminished reactive oxygen species production and the depolarization of mitochondrial membrane potential in hepatocytes extracted from animal livers treated with Tamarix articulata extract. Our findings suggest that Tamarix articulata extract prevents liver fibrosis induced by carbon tetrachloride and decreases the necrotic population of hepatocytes. These events restored the antioxidant enzymatic activity, serum levels of liver enzymes, and pro-inflammatory markers to their normal levels.

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“…Therefore, it is necessary to search for safe and effective natural drugs to prevent and treat liver diseases. [ 93,94 ] Numerous studies have confirmed that polysaccharides and their derivatives could improve and treat liver related diseases by enhancing the body's antioxidant capacity, increasing immune regulatory activity, and improving anti‐inflammatory effects. [ 95,96 ] Figure shows the liver protective activity mechanism of phosphorylated polysaccharides.…”

Section: Biological Activities Of Phosphorylated Polysaccharidesmentioning

confidence: 99%

Modification, Structure Identification, and Biological Activities of Phosphorylated Polysaccharides: A Review

Gao,

Liu,

Dai

et al. 2024

Starch Stärke

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Polysaccharides are a kind of biological macromolecule, which widely exists in plants, fungi, animals, microorganisms, and other organisms. Polysaccharides exhibit various biological activities such as immunological regulation, antioxidation, antitumor, antiinflammatory, regulating intestinal flora, and protecting liver. These biological activities depend on their structure and physicochemical properties including monosaccharide composition, molecular weight (Mw), spatial configuration, etc. However, biological activities of polysaccharides are hardly comparable to synthetic drugs due to their inherent physicochemical properties. Therefore, structural modification of polysaccharides is an effective way to enhance their biological activities and promote the presentation of bioactivity. At present, phosphorylation modification is a common chemical modification method, which can effectively improve the biological activities of polysaccharides. However, there are limited reports on the synthesis, structure identification, and biological activities of phosphorylated polysaccharides. In view of this, the synthesis methods, structure identification methods, and biological activities of phosphorylated polysaccharides are reviewed in this paper. The findings can provide useful guidance for the research, production, and application of phosphorylated polysaccharides in functional foods and therapeutic agents.

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Evaluation of the hepatoprotective activity of hydroalcoholic extract of Alhagi camelorum against valproic acid-induced hepatotoxicity in rats

Cited by 13 publications

References 29 publications

Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Reversal of Valproate‐Induced Major Salivary Gland Changes By Moringa Oleifera Extract in Rats

Tamarix articulata Induced Prevention of Hepatotoxicity Effects of In Vivo Carbon Tetrachloride by Modulating Pro-Inflammatory Serum and Antioxidant Enzymes to Reverse the Liver Fibrosis

Modification, Structure Identification, and Biological Activities of Phosphorylated Polysaccharides: A Review

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