Evaluation of the immune response and protective effects of rhesus macaques vaccinated with biodegradable nanoparticles carrying gp120 of human immunodeficiency virus

Comparative activity of biodegradable nanoparticles with aluminum adjuvants: Antigen uptake by dendritic cells and induction of immune response in mice

“…4-6). Furthermore, the potent adjuvant activity of ␥-PGA NPs was observed for various antigens, including HIV-1 p24 and gp120, influenza virus hemagglutinin, and a peptide derived from tumor-associated antigen, irrespective of different immunization routes [13][14][15][16][17]21,22]. In these studies, it is of note that a significant expansion of CD8 + T-cells specific to MHC-I-restricted antigen epitopes was observed in mice and macaques immunized with antigen-carrying ␥-PGA NPs.…”

“…Our previous study showed that ␥-PGA NPs were efficiently taken up by immature DCs and did induce their maturation [13]. In addition, immunization with antigen-carrying ␥-PGA NPs strongly induced antigen-specific cellular immune responses in mice and rhesus macaques [14,15]. In this study, ␥-PGA NPs were examined for their uptake by murine DCs and induction of antigen-specific immune responses in mice and compared with AL-based adjuvants.…”

“…We have previously reported that poly(␥-glutamic acid) (␥-PGA) nanoparticles (NPs) have great potential as an adjuvant and carrier of various antigens in vaccines [13][14][15][16][17]. ␥-PGA is a naturally occurring water-soluble, biodegradable, edible, and non-toxic polyamino acids synthesized by certain strains of bacillus.…”

The Cellular and Molecular Biology of HIV-1 Broadly Neutralizing Antibodies

“…Another multimerization approach uses multiple-antigen peptides, which allow for presentation of two to eight immunogens. Env gp120 nanoparticles have elicited only binding antibodies that failed to protect macaques from SHIV infection [152]. Env gp120 nanoparticles have elicited only binding antibodies that failed to protect macaques from SHIV infection [152].…”

A review of nanotechnological approaches for the prophylaxis of HIV/AIDS

“…This indicates potential of PGA nanoparticles in vaccine delivery. Himeno et al, compared immune responses after administration of HIV gp120 and PGA nanoparticles containing HIV gp120 to rhesus macaques [124]. PGA nanoparticles elicited stronger gp120-specific cellular and humoral immune responses than gp120 alone.…”