Evaluation of the immunogenic capability of the BCG strains BCGΔBCG1419c and BCGΔBCG1416c in a three-dimensional human lung tissue model

Parasa, Venkata Ramanarao; Rose, Jeronimo; Castillo-Diaz, Luis Alberto; Aceves-Sánchez, Michel de Jesús; Vega-Domínguez, Perla Jazmín; Lerm, Maria; Flores-Valdéz, Mario Alberto

doi:10.1016/j.vaccine.2018.02.044

Cited by 1 publication

(1 citation statement)

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“…In this system, Mtb dormancy was demonstrated, with subsequent Mtb resuscitation with immunosuppressive treatment. An alternative lung tissue model of TB has been generated by combining epithelial cells and fibroblasts embedded in collagen with Mtb-infected primary human monocyte-derived macrophages [21][22][23][24]. This system has been used to demonstrate that matrix metalloproteinase inhibition reduces granuloma size and bacterial load.…”

Section: Emerging Advanced Cellular Modelsmentioning

confidence: 99%

Advanced cellular systems to study tuberculosis treatment

Bielecka

Elkington

2018

Current Opinion in Pharmacology

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Mycobacterium tuberculosis (Mtb) kills more humans than any other infection and drug resistant strains are progressively emerging. Whilst the successful development of new agents for multi-drug resistant Mtb represents a major step forward, this progress must be balanced against recent disappointments in treatment-shortening trials. Consequently, there is a pressing need to strengthen the pipeline of drugs to treat tuberculosis (TB) and develop innovative therapeutic regimes. Approaches that bridge diverse disciplines are likely to be required to provide systems that address the limitations of current experimental models. Mtb is an obligate human pathogen that has undergone extensive co-evolution, resulting in a complex interplay between the host and pathogen. This chronic interaction involves multiple micro-environments, which may underlie some of the challenges in developing new drugs. The authors propose that advanced cell culture models of TB are likely to be an important addition to the experimental armamentarium in developing new approaches to TB, and here we review recent progress in this area and discuss the principal challenges.

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Section: Emerging Advanced Cellular Modelsmentioning

confidence: 99%