Evaluation of the isoflurane-sparing effects of lidocaine infusion during umbilical surgery in calves

Vesal, Nasser; Spadavecchia, Claudia; Steiner, Adrian; Kirscher, Franziska; Levionnois, Olivier

doi:10.1111/j.1467-2995.2011.00636.x

Cited by 28 publications

(23 citation statements)

References 41 publications

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“…In another study using morphine intravenously (2 mg kg -1 ) in goats, Doherty et al (2004) observed a 29.7% reduction of the MAC of isoflurane. In calves, the end-tidal concentration of isoflurane was significantly lower in the group treated with 50 µg kg -1 minute -1 lidocaine, indicating a 16.7% reduction in anesthetic requirement during lidocaine CRI (VESAL et al, 2011).…”

Section: Discussionmentioning

confidence: 97%

“…Kästner et al (2006) observed a 30% reduction in the FE´Iso concentration after premedication with medetomidine in sheep. Dose-dependent anesthetic sparing effects of medetomidine have been demonstrated in a variety of species (VICKERY et al, 1988;MAZE, 1989). A reduction of up to 90% of the minimum alveolar concentration (MAC) of halothane was observed in dogs after 10 ug kg -1 of medetomidine IV (VICKERY et al, 1988).…”

Section: Discussionmentioning

confidence: 99%

“…Dose-dependent anesthetic sparing effects of medetomidine have been demonstrated in a variety of species (VICKERY et al, 1988;MAZE, 1989). A reduction of up to 90% of the minimum alveolar concentration (MAC) of halothane was observed in dogs after 10 ug kg -1 of medetomidine IV (VICKERY et al, 1988). This is a clinical study, and we used animals that were submitted to gastrointestinal surgery for duodenal cannula implantation.…”

Section: Discussionmentioning

confidence: 99%

“…Intravenous lidocaine has been used to supplement general anesthesia and to decrease postoperative pain when administered during the preoperative period (KOPPERT et al, 2004). In calves, the end-tidal concentration of isoflurane was significantly lower in groups treated with 50 µg kg -1 minute -1 lidocaine, representing a 16.7% reduction in anesthetic requirement during lidocaine CRI (VESAL et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Effects of the morphine-lidocaine-ketamine combination on cardiopulmonary function and isoflurane sparing in sheep

Beier

Rosa

Oleskovicz³

et al. 2014

Sem. Ci. Agr.

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The aims of this study were to evaluate the isoflurane sparing and clinical effects of a constant rate infusion of morphine -lidocaine -ketamine (MLK) in healthy sheep undergoing experimental gastrointestinal surgery. Twelve adult female sheep (Texel breed) were used, weighing 36.5 ± 8.1 kg. The sheep were anesthetized for the implantation of duodenal cannulas. The sheep were premedicated with 0.3 mg kg -1 intramuscular (IM) morphine and 20 µg kg -1 intravenous (IV) detomidine. After premedication, anesthesia was induced using 5 mg kg -1 ketamine and 0.5 mg kg -1 diazepam IV and maintained using isoflurane in 100% oxygen. After the induction of anesthesia, the animals were allocated into two groups (each n=6); the GMLK (MLK group -10 mg morphine, 150 mg lidocaine, 30 mg de ketamine were added in 500 mL saline) received a 10 mL kg -1 h -1 MLK infusion during the maintenance of anesthesia, and GCON (control group) received 10 mL kg -1 h -1 of 0.9% sodium chloride. The animals were mechanically ventilated. Cardiopulmonary variables and end-tidal isoflurane concentration (FE´Iso) were measured at baseline (immediately before the surgery) and 15, 30 and 45 minutes after initiation of surgery. In GMLK, there was a decrease in the FE´Iso at 15, 30 and 45 minutes, a reduction of up to 75.6% during the surgery. The HR was lower in GMLK compared with GCON at 30 minutes, and the MAP was at during baseline in GCON compared with GMLK. The standing time was less in GMLK than in GCON. The use of intravenous MLK was demonstrated to offer great efficiency as part of a balanced anesthesia protocol in sheep, with a 75.6% reduction in the need for isoflurane, providing stability of the cardiovascular parameters and blood gases with a shortened recovery period. Key words: Sheep, morphine, lidocaine, ketamine, isoflurane ResumoOs objetivos deste estudo foram avaliar a redução na concentração expirada de isoflurano, bem como os efeitos clínicos de uma infusão constante de morfina -lidocaína -cetamina (MLK) em ovinos saudáveis submetidos a cirurgia gastrointestinal experimental. Foram utilizados doze ovinos adultos da raça Texel, fêmeas, pesando 36,5 ± 8,1 kg. Os animais foram anestesiados para implantação de cânulas no duodeno, sendo pré-medicados com morfina 0,3 mg kg -1 , pela via intramuscular (IM), e detomidina 20 ug kg -1 pela via intravenosa (IV). Após a pré-medicação, a anestesia foi induzida com cetamina 5 mg kg -1 e diazepam 0,5 mg kg -1 IV, sendo mantidos com isoflurano em oxigênio a 100%. Após a indução da anestesia os animais foram divididos em dois grupos (n = 6): GMLK (grupo MLK -10 mg de morfina, 150 mg de lidocaína e 30 mg de cetamina foram adicionados em 500 ml de solução salina) que recebeu infusão contínua de MLK na taxa de 10 mL kg

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effects of the morphine-lidocaine-ketamine combination on cardiopulmonary function and isoflurane sparing in sheep

Beier

Rosa

Oleskovicz³

et al. 2014

Sem. Ci. Agr.

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“…Additionally, several studies have shown that lidocaine infusion reduces the minimum alveolar concentration (MAC) of inhalation agents in horses 15 , dogs [16][17][18][19] , goats 20 , cats 21 and calves 22 .…”

Section: Introductionmentioning

confidence: 99%

Analgesic comparison of systemic lidocaine, morphine or lidocaine plus morphine infusion in dogs undergoing fracture repair

et al. 2014

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Intellectual and scientific content of the study, statistical analysis, critical revision. ABSTRACT PURPOSE:To compare the postoperative analgesic effects of lidocaine, morphine and lidocaine plus morphine administered by constant rate infusion (CRI) and analyzing their effects on opioid requirements after orthopedic surgery in dogs. METHODS:Twenty-four dogs underwent fracture repairs were premedicated with IM acepromazine (0.05 mg/kg) combined with morphine (0.3mg/kg). Anesthesia was induced with IV propofol (4 to 5 mg/ kg) and maintained with isoflurane. The dogs were randomly assigned to 3 groups and administered a CRI IV of lidocaine (T-L), morphine (T-M) or lidocaine plus morphine (T-LM) at the same doses. Postoperative analgesia was assessed for 24 hours using a Visual Analog Scale (VAS) and the Glasgow Composite Pain Scale (GCPS). Rescue analgesia was performed if the evaluation score exceeded 50% of the VAS and/or 33% of the GCPS. RESULTS:The pain score and postoperative opioid requirements did not differ among the treatments. Rescue analgesia was administered to 1/8 dogs in the T-M and T-LM, and to 3/8 dogs in the T-L. CONCLUSION:Lidocaine, morphine or lidocaine/morphine CRI may be efficacious techniques for pain management in the first 24 hours post-surgery. However, the two drugs administered together did not reduce the postoperative opioid requirement in dogs undergoing fracture repair.

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Pain management for farm animals

Lin

2014

Farm Animal Anesthesia

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Evaluation of the isoflurane-sparing effects of lidocaine infusion during umbilical surgery in calves

Cited by 28 publications

References 41 publications

Effects of the morphine-lidocaine-ketamine combination on cardiopulmonary function and isoflurane sparing in sheep

Effects of the morphine-lidocaine-ketamine combination on cardiopulmonary function and isoflurane sparing in sheep

Analgesic comparison of systemic lidocaine, morphine or lidocaine plus morphine infusion in dogs undergoing fracture repair

Pain management for farm animals

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