Evaluation of the Oxidative Stability of Wholegrain Flours Using Nontargeted Ultraperformance Liquid Chromatography Coupled with Electrospray Ionization Quadrupole Time-of-Flight (UPLC-ESI-QTOF) Metabolomics

Wei, Chun Yue; Zhu, Dan; Ryback, Brendan M; Nyström, Laura

doi:10.1021/acsfoodscitech.0c00161

Cited by 3 publications

(1 citation statement)

References 41 publications

(109 reference statements)

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“…Of note, change in hexadecanedioic acid level was reported to be related to inflammatory status, and it contributed to the classification of SCZ and HCs in previous studies ( Cui et al, 2020 ; Qian et al, 2021 ). The diacylglyceryl-N,N,N-trimethylhomoserine (DGTS)16:0/18:1 level is considered a biomarker reflecting low oxidative stability among wheat varieties ( Wei et al, 2021 ). A meta-analysis has revealed that first-episode psychiatric patients exhibited a proinflammatory and vulnerable antioxidant status ( Fraguas et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles

Tao

Zhang

Wang

et al. 2022

Front. Cell Dev. Biol.

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Emerging evidence has demonstrated overlapping biological abnormalities underlying schizophrenia (SCZ), bipolar disorder (BP), and major depressive disorder (MDD); these overlapping abnormalities help explain the high heterogeneity and the similarity of patients within and among diagnostic categories. This study aimed to identify transdiagnostic subtypes of these psychiatric disorders based on lipidomics abnormalities. We performed discriminant analysis to identify lipids that classified patients (N = 349, 112 with SCZ, 132 with BP, and 105 with MDD) and healthy controls (N = 198). Ten lipids that mainly regulate energy metabolism, inflammation, oxidative stress, and fatty acylation of proteins were identified. We found two subtypes (named Cluster 1 and Cluster 2 subtypes) across patients with SCZ, BP, and MDD by consensus clustering analysis based on the above 10 lipids. The distribution of clinical diagnosis, functional impairment measured by Global Assessment of Functioning (GAF) scales, and brain white matter abnormalities measured by fractional anisotropy (FA) and radial diffusivity (RD) differed in the two subtypes. Patients within the Cluster 2 subtype were mainly SCZ and BP patients and featured significantly elevated RD along the genu of corpus callosum (GCC) region and lower GAF scores than patients within the Cluster 1 subtype. The SCZ and BP patients within the Cluster 2 subtype shared similar biological patterns; that is, these patients had comparable brain white matter abnormalities and functional impairment, which is consistent with previous studies. Our findings indicate that peripheral lipid abnormalities might help identify homogeneous transdiagnostic subtypes across psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles

Tao

Zhang

Wang

et al. 2022

Front. Cell Dev. Biol.

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Untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometry

Bozza,

Barboni,

Spadafora

et al. 2024

Journal of Chromatography Open

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Gabi wheat a panel of European elite lines as central stock for wheat genetic research

et al. 2022

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In plant sciences, curation and availability of interoperable phenotypic and genomic data is still in its infancy and represents an obstacle to rapid scientific discoveries in this field. To that end, supplementing the efforts being made to generate open access wheat genome, pan wheat genome and other bioinformatic resources, we present the GABI-WHEAT panel of elite European cultivars comprising 358 winter and 14 summer wheat varieties released between 1975 to 2007. The panel has been genotyped with SNP arrays of increasing density to investigate several important agronomic, quality and disease resistance traits. The robustness of investigated traits and interoperability of genomic and phenotypic data was assessed in the current publication with the aim to transform this panel into a public data resource for future genetic research in wheat. Consecutively, the phenotypic data was formatted to comply with FAIR principles and linked to online databases to substantiate panel origin information and quality. Thus, we were able to make a valuable resource available for plant science in a sustainable way.

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Evaluation of the Oxidative Stability of Wholegrain Flours Using Nontargeted Ultraperformance Liquid Chromatography Coupled with Electrospray Ionization Quadrupole Time-of-Flight (UPLC-ESI-QTOF) Metabolomics

Cited by 3 publications

References 41 publications

Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles

Identifying transdiagnostic biological subtypes across schizophrenia, bipolar disorder, and major depressive disorder based on lipidomics profiles

Untargeted metabolomics approaches for the characterization of cereals and their derived products by means of liquid chromatography coupled to high resolution mass spectrometry

Gabi wheat a panel of European elite lines as central stock for wheat genetic research

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