2014
DOI: 10.1007/s00540-014-1795-9
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Evaluation of the peripheral analgesic effect of sufentanil lipid nanoparticles

Abstract: Sufentanil lipid nanoparticles had a comparatively weak effect on the central nervous system because of their features such as large particle size and targeted and controlled release. They have shown a remarkable analgesic effect in the peripheral inflammatory pain areas.

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Cited by 3 publications
(5 citation statements)
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“…On the other hand, both commercial and NLC forms of drug have directly affected the central nervous system. 30,31 Nanostructure form of the sample can circulate easily through the bloodstream due to its hydrophilic nature in comparison to pure drug. 32 Indeed, it has better performance in transferring the drug to the central nervous system.…”
Section: Formalin Test Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…On the other hand, both commercial and NLC forms of drug have directly affected the central nervous system. 30,31 Nanostructure form of the sample can circulate easily through the bloodstream due to its hydrophilic nature in comparison to pure drug. 32 Indeed, it has better performance in transferring the drug to the central nervous system.…”
Section: Formalin Test Resultsmentioning
confidence: 99%
“…Similar behavior was observed in another study. In 2014, Li et al 30 used a formalin test to study the analgesic effect of sufentanil and sufentanil lipid nanoparticles on mice. They observed that sufentanil lipid nanoparticles can reduce the pain caused by formalin injection to the mouse to some extent compared with the time of single injection of sufentanil.…”
Section: Formalin Test Resultsmentioning
confidence: 99%
“…Single-dose EREM can offer up to 2 days of postoperative analgesia. [44] lidocaine-embedded in poly nanofibers Lidocaine-loaded nanofibers effectively and easily delivered post-laminectomy analgesia [51] Morphine sulfate Morphine sulfate shown a significant analgesic effect [55] Sufentanil loaded on lipid nanoparticles Sufentanil lipid nanoparticles shown a significant analgesic effect [52] Nano-formulated diclofenac Nano-formulated diclofenac had a high rate of absorption and decreased drug exposure compared with standard diclofenac.…”
Section: Nano-formulated Drug Results Referencementioning
confidence: 99%
“…Li and co-worker also investigated the efficacy of analgesic effect of sufentanil loaded on lipid nanoparticles. They concluded that sufentanil loaded on lipid nanoparticles had a relatively weak effect on the CNS and exhibited a significant palliative effect in the outer inflammatory pain regions [52]. Nano-formulated diclofenac was mostly well accepted when compared to placebo and no health side effects reported [40].…”
Section: Nano-drugs and Chronic Painmentioning
confidence: 99%
“…However, the limited distribution of the nanoparticle outside the inflammatory zone could help to obtain a good adverse reaction profile, although this remains to be confirmed. Of course, this interest in the targeting capabilities of nanoparticles can be applied to exogenous opioids, the key point being probably more the specific targeting than the nature of the ligand (Hua & Cabot, 2013;Li et al, 2014).…”
Section: Using Endogenous Opioids As Drugsmentioning
confidence: 99%