Evaluation of the predictive values of collapse and necrotic lesion boundary for osteonecrosis of the femoral head prognosis

Fan, Yinuo; Liu, Xuejie; Zhong, Yuan; Zhang, Jiahao; Wang, Kun; Fang, Hanjun; He, Wei; Zhou, Chi; Chen, Zhenqiu

doi:10.3389/fendo.2023.1137786

Cited by 6 publications

(1 citation statement)

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“…Osteonecrosis of the femoral head (ONFH) is a progressive debilitating lesion associated with many diseases, including trauma, steroid use, alcohol abuse and hypercholesterolemia, including some common clinical manifestations such as pain or limitation of motion [3,4] . ONFH is one of the devastating complications of systemic steroid use, and long-term steroid use leads to a hyperlipidemic state in most patients and exposes them to risk of osteoporosis and osteonecrosis [5] .…”

Section: Introductionmentioning

confidence: 99%

Potential mechanisms for predicting comorbidity between multiple myeloma and femoral head necrosis based on multiple bioinformatics

Li,

Dong,

et al. 2023

Preprint

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Objective: To explore Multiple myeloma (MM) through multiple bioinformatics analysis The potential mechanism of comorbidity with Osteonecrosis of the femoral head (ONFH). Method:According to the inclusion criteria, download the MM and ONFH high-throughput chip datasets from the GEO database and preprocess them separately. Using weighted gene co expression network analysis (WGCNA) to construct co expression networks on MM self datasets, further screening modules and genes related to MM clinical characteristics, enriching and analyzing potential co disease genes of NAFLD and IS, and preliminarily screening key genes for MM and ONFH co disease through Cytoscape. Validate the ability of gene expression and performance evaluation through two disease related datasets. And evaluate the relationship between the difference and consistency of the two in the immune microenvironment. Results: Through screening 418 co pathogenic genes with immunity, we found that the biological process of the two kinds of diseases in the ribosome synthesis process was consistent, especially the protein synthesis. Further screening key genes through PPI, and analyzing the dataset of the validation queue, the average area (ROC) of the 5 genes under the operating characteristics of the subjects was between 0.8 and above. Comparing the analysis of the two groups of data in the immune microenvironment, it is found that the infiltration of plasma cell is consistent with the comorbidity of diseases, and it can be used as the relevant immune target for subsequent targeting. Conclusion: MM and ONFH share common pathogenic genes, which in turn mediate differential changes in related signaling channels and immune cells, affecting the high incidence of OA and MDS and the phenomenon of these two diseases. In terms of biological mechanism, MM and ONFH co disease may be mainly associated with RPS19, RPL35, RPL24, RPL36, EIF3G as key genes, as well as plasma cell as key immune infiltration, which can serve as the central mechanism for the development of the two diseases. This study provides ideas and references for further research.

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Section: Introductionmentioning

confidence: 99%