Evaluation of the Protective Effect of Ethanolic Extract of Plantago major Plant Against CCl4 Induced Genotoxicity and Biochemical Disturbance in Rat

Abstract

HIS STUDY was carried out through 2010-2014, seasons on on …fresh herbs of Plantago major plant, which was collected from a private nurseries of El Qanater el Khayreyya, Al-Qaluobia Governorate, Egypt. The aim of this study was to investigate the protective potential of ethanolic crud extract of Plantago major against oxidative stress induced by carbon tetrachloride (CCl 4) in different tissues in rats. Our results observed that CCl4 exhibited a significant increase in the levels of serum glucose and lipid profile i.e. total cholesterol, triglyceride and low density lipoprotein cholesterol (LDL) with a significant decrease in the level of high density lipoprotein cholesterol (HDL). Also, CCl4 increase liver function including serum aminotransferases (AST and ALT), alkaline phosphatase (ALPh), total protein, albumin (ALB) and total bilirubin activities and kidney function including the levels of serum urea, uric acid and creatinine amounts. Treatment with ethanolic P. major extract at 100mg/kg b.wt before, with and after treatment with CCl4 significantly prevented all of these typically observed changes. Also, P. major extract statistically significant (P<0.01) inhibit DNA damage induced by CCl4 in bone marrow and sperms of rats. Our findings indicate that P. major has a significant protective effect against CCl4 induced genotoxicity and biochemical changes in rat, which may be due to its antioxidant properties.

A Preliminary Study on the Effect of Psyllium Husk Ethanolic Extract on Hyperlipidemia, Hyperglycemia, and Oxidative Stress Induced by Triton X-100 Injection in Rats

“…Psyllium husk was obtained from the local markets for medicinal Plants, Cairo, Egypt, and accredited by the Department of Botany, Faculty of Agriculture, Zagazig University, Egypt. The psyllium husks were dried at 55 °C, ground to a fine powder, and subjected to extraction procedures, according to Nofal et al [ 11 ]. The powder (250 g) was extracted in 1L 70% ethanol in dark-colored bottles by maceration (36 h).…”

Phytochemical Screening, Antifungal, and Anticancer Activities of Medicinal Plants Thymelaea Hirsuta, Urginea Maritima, and Plantago Albicans

“…Aromatic and medicinal plants used for a long time in traditional medicine have been the subject of numerous studies to analyze their chemical composition and evaluate their pharmaceutical properties as antifungal agents for the treatment of various fungal illnesses [10]. El-Demerdash [11] reported that due to Egypt's ecological diversity, the traditional pharmacopoeia contains a vast resource of medicinal plants that have long been used in folk medicine to treat many diseases as demonstrated on temple walls and papyrus, such as the well-known Ebers Papyrus of 1550 BC documented 876 medicaments with 328 diverse components derived from many plant species including Thymelaea hirsuta L., Urginea maritima L., and Plantago albicans L. Medicinal plants T. hirsuta L., U. maritima L., and P. albicans L. endemic to Egypt and the coastal Mediterranean region and commonly used as antiulcer, anti-inflammatory, antigiardiasic, antimalarial, anticancer, wound healing, immunomodulatory, antibacterial, antioxidant, hypoglycaemic, hepatoprotective, cytotoxic, and hypolipidemic agents attributed to their high glycosides, flavonoids, reducing compounds, tannins, anthraquinones, mucilage, anthocyanins, fatty acids, polysaccharides, steroids, and terpenes contents [12][13][14][15][16][17].…”

In Vitro, Evaluation of Anticancer and Anti-dermatophytes Activities of Some Egyptian Medicinal Plants&nbsp;

“…In Egypt, P. albicans, T. hirsuta and U. maritima are medicinal plants endemic to Egypt, grow in the coastal Mediterranean region, commonly used for its biological properties including anti-ulcerogenic, anti-in ammatory, antigiardiasic, antimalarial, anticancer, immunomodulatory, wound healing, antioxidant, antibacterial, antihypoglycaemic, hepatoprotective, hyperlipidemic, haemopoietic and cytotoxic activities (Elghuol et al 2016;Nofal et al 2016;Felhi et al 2017) which attributed to their higher content of avonoids, glycosides, tannins, reducing compounds, anthraquinones, anthocyanins, mucilage, polysaccharides, fatty acids, triterpenes and steroids in traditional medicinal (Elghuol et al 2016;Belhadda et al 2017).…”